辩证分析兴奋性氨基酸对神经细胞的双重作用

兴奋性氨基酸（ＥＡＡｓ） 广泛分布于中枢神经系统,参与多种生理过程包括学习、记忆和伤害感受等。然而,ＥＡＡｓ 受体的过度兴奋却可引发一系列细胞事件,最终导致神经元的损伤与死亡。许多神经退行性疾病如早老性痴呆、癫痫和肌侧索硬化症等都与ＥＡＡｓ 的兴奋毒作用有关。目前的研究表明,由ＥＡＡｓ 受体过度兴奋所引发的细胞内钙超载是导致神经元死亡的最终途径     

A Bootstrapping Model of Frequency and Context Effects in Word Learning

Prior research has shown that people can learn many nouns (i.e., word–object mappings) from a short series of ambiguous situations containing multiple words and objects. For successful cross‐situational learning, people must approximately track which words and referents co‐occur most frequently. This study investigates the effects of allowing some word‐referent pairs to appear more frequently than others, as is true in real‐world learning environments. Surprisingly, high‐frequency pairs are not always learned better, but can also boost learning of other pairs. Using a recent associative model (Kachergis, Yu, & Shiffrin, 2012), we explain how mixing pairs of different frequencies can bootstrap late learning of the low‐frequency pairs based on early learning of higher frequency pairs. We also manipulate contextual diversity, the number of pairs a given pair appears with across training, since it is naturalistically confounded with frequency. The associative model has competing familiarity and uncertainty biases, and their interaction is able to capture the individual and combined effects of frequency and contextual diversity on human learning. Two other recent word‐learning models do not account for the behavioral findings.     

解题策略的同质性和线性逻辑斯谛模型的拟合

为探讨线性逻辑斯谛模型（ＬＬＴＭ）的拟合条件及其和解题策略同质性之间的关系,让被试比较两个负整数指数幂的大小,发现全体被试的数据不能与拉希模型及ＬＬＴＭ相拟合。把被试按其解题策略分成不同策略组后,同一策略组被试的数据可以拟合于拉希模型,但对于ＬＬＴＭ,同一策略组的数据中部分项目的拟合较好,另外一些项目的拟合较差。这一结果表明,解题策略的同质性是ＬＬＴＭ拟合的必要条件,但还不是充分条件。     

Uptake of Cardiac Screening and Genetic Testing Among Hypertrophic and Dilated Cardiomyopathy Families

Cardiomyopathy is a genetically and clinically heterogeneous, life threatening disease which affects people of all ages. Recent guidelines provide recommendations for cardiac screening and genetic testing in at-risk relatives, but the uptake and impact of these measures in the United States is unknown. This is a single institution retrospective study that characterizes the uptake of cardiac screening and genetic testing for relatives of a cohort of 57 probands with hypertrophic (HCM) and dilated cardiomyopathy (DCM) who underwent both clinical evaluation and genetic testing. Cardiac screening was indicated for 302 relatives. One hundred and seventy-three (57 %) completed cardiac screening. Forty of the 57 probands were mutation positive and genetic testing was indicated for 213 relatives. Eighty-four (39 %) completed genetic testing. The uptake of cardiac surveillance was greater than the uptake of genetic testing (p?<?0.0001) among relatives of mutation positive probands. Within the group of at-risk, asymptomatic relatives of probands, cardiac screening and genetic testing were positive in 25 % and 40 % of cases, respectively. These data demonstrate the important role and utility of cascade cardiac screening and genetic testing in the care of patients and families with HCM or DCM. The approach to cardiac screening and genetic testing should be family-specific and requires expertise in the genetics of cardiomyopathy.     

Nest box entrance hole size can influence nest site selection and nest defence behaviour in Japanese tits

Animal Cognition - Birds have the ability to assess the risk of predation in their environment and adjust their antipredation strategies based on this risk information. However, whether nest site...     

A critique of Dennett

This essay is intended to be a systematic exposition and critique of Daniel Dennett's general views. It is divided into three main sections. In section 1 we raise the question of the nature of a plausible scientific psychology, and suggest that the question of whether folk psychology will serve as an adequate scientific psychology is of special relevance in a discussion of Dennett. We then characterize folk psychology briefly. We suggest that Dennett's views have undergone at least one major change, and proceed to discuss both his earlier and his later views.In section 2 we suggest that Dennett is correctly perceived as an instrumentalist in his earlier works. We think that Dennett later abandons this position because of general worries about instrumentalism and, more importantly, because Dennett became convinced that an instrumentalist conception of folk psychology will not enable us to vindicate the notions of personhood, moral agency, and responsibility. This left Dennett with a dilemma. On the one hand, he does not think that beliefs, etc., will turn out to be genuine scientific posits. On the other hand, he thinks that moral agency would be impossible if we could not treat beliefs, etc. as causally efficacious in some suitable sense.In section 3 we discuss Dennett's resolution of this dilemma. The key to his current view, we suggest, is the illata-abstracta distinction. Dennett holds that both illata and abstracta are real and have causal powers, even though only illata are genuine scientific posits. He suggests that beliefs etc. are abstracta, and are the subject matter of what he calls intentional system theory. The subject matter of another theory, what Dennett calls subpersonal cognitive psychology, are illata, which are subpersonal intentional states. The important point is that this distinction lets Dennett have it both ways: (i) Since beliefs are mere abstracta, we need not commit ourselves to the thesis that beliefs will turn out to be posits of an adequate scientific psychology. (ii) Since beliefs have causal power, we are assured of moral and rational agency. We shall argue that Dennett's current view is untenable. If we are right in our arguments, then Dennett's program to produce a scientifically plausible psychology, one that will turn out to vindicate folk psychology (in some suitable sense), is a failure. It fails in the following important ways: (i) What Dennett sketches — intentional system theory cum subpersonal cognitive psychology — is not a plausible scientific psychology. (ii) As a consequence, Dennett also fails to provide a satisfactory foundation for moral and rational agency.     

Do recognizable figures enjoy an advantage in binocular rivalry?

Five experiments examined whether recognizable stimuli predominate in binocular rivalry. It was found that a face predominated more than did a pattern equated for spatial frequency, luminance, and contrast; an objective reaction time procedure confirmed predominance of the face. The face was still liable to fragmentation as stimulus size increased. Observers tracked exclusive dominance of a picture of a camouflaged figure (a Dalmatian dog) prior to and then following discovery of the figure's presence; control observers received the same protocol with a scrambled version of the dog stimulus. Compared with control results, predominance of the dog picture was higher even before observers knew of the camouflaged figure. Inversion of the dog figure reduced its predominance. Binocular rivalry is sensitive to object-related, configural properties of a stimulus.     

试论庄子“亚齐物”境界及其对古代文人精神的影响

庄子哲学在先秦时期是不同于儒、墨、法等诸家政治哲学的。一部《庄子》,诙诡奇谲,洋洋洒洒,倾注的是庄子对生命深切的终极关怀———人的命运和精神自由。庄子笔下,各色人物你方唱罢我登场。当中有逍遥游于天地,与造化相流行的神人,以己意出法令的人间帝王,欲致君尧舜的士人,恶于世的隐者,普通的匠     

Framing Charity Advertising: Influences of Message Framing,Image Valence,and Temporal Framing on a Charitable Appeal1

This study examined when and how charitable advertisements could be effective in the context of child poverty. An experiment investigated the influences of message framing, image valence, and temporal framing on a charitable appeal. The results indicate that image valence enhances framing effects on advertising effectiveness of a charitable appeal when the image is congruent with the framed message, especially when the image and the message are presented negatively. A short‐term temporal frame facilitates effects of a negatively framed message with a negative pictorial presentation. Alternatively, a long‐term temporal frame increases advertising influences of a positively framed message with a positive pictorial image. Relevance for information processing of charity advertising is discussed.     

南北朝道教重玄学初探

一、重玄学思想之渊源南北朝时期重玄学的快速发展,一方面是由于大量士族文人加盟道坛,并运用重玄的思维方式注疏老庄,希望在提升道教理论品位的同时,建构道教圆融的经教体系;另一方面是由于佛道之争的需要,使得道教不得不自觉地加强自身教义理论建设,以期与善于精思析理的佛教