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641.
The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice 总被引:2,自引:0,他引:2
Kim DH Jeon SJ Son KH Jung JW Lee S Yoon BH Lee JJ Cho YW Cheong JH Ko KH Ryu JH 《Neurobiology of learning and memory》2007,87(4):536-546
Oroxylin A is a flavonoid and was originally isolated from the root of Scutellaria baicalensis Georgi., one of the most important medicinal herbs in traditional Chinese medicine. The aim of this study was to investigate the ameliorating effects of oroxylin A on memory impairment using the passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by administering scopolamine (1 mg/kg, i.p.) or diazepam (1 mg/kg, i.p.). Oroxylin A (5 mg/kg) significantly reversed cognitive impairments in mice by passive avoidance and the Y-maze testing (P<.05). Oroxylin A also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P<.05). Moreover, the ameliorating effects of oroxylin A were antagonized by both muscimol and diazepam (0.25 mg/kg, i.p., respectively), which are GABA(A) receptor agonists. Furthermore, oroxylin A (100 microM) was found to inhibit GABA-induced inward Cl(-) current in a single cortical neuron. These results suggest that oroxylin A may be useful for the treatment of cognitive impairments induced by cholinergic dysfunction via the GABAergic nervous system. 相似文献
642.
The moderating role of intergroup contact on the relationship between perceived discrimination and ethnic identity was examined in a diaspora community of Koreans living in China. It was hypothesized that Koreans with higher intergroup contact would have a lower ethnic identity under higher discrimination, whereas Koreans with lower intergroup contact would have a higher ethnic identity. Across two separate college samples, Koreans who were more willing to interact with Han Chinese had a lower ethnic identity when discrimination was higher, but this finding was not replicated within one college setting. These findings challenge the linear rejection-identification model and suggest displaced people may minimize ingroup-outgroup differences, depending on their willingness to seek intergroup contact. 相似文献
643.
644.
本研究通过三个实验考察了语义联系和因果制约对文本阅读中预期推理激活和编码的贡献。结果表明,预期语境与预期事件间的语义联系不能使预期推理在文本阅读过程中得到激活和编码,语境与预期事件间的强因果关系是文本阅读过程中预期推理激活与编码的必要条件;提示阅读过程中的预期是因果预期而非联想预期。结果为建构主义推理观提供了实验依据。 相似文献
645.
本研究运用结构性观察方法对两组4岁儿童与父母在四种活动中的互动进行了分析与比较。一组儿童为书面数符号测查高分者,二组儿童为书面数符号测查低分者。85对父母一儿童对子参加了4个各有15分钟的共同活动,阅读、数学题、纸和积木,并完成一个微型问卷。结果表明,在这些活动中包含了多种数学知识学习和多种以父母为主导的互动策略;两组对子之间在数学事件频次上无差异,但一组父母更多地运用了一些积极策略,二组父母更多地运用了一些消极策略;二组中有更多儿童对互动表现出消极回应和注意力问题。两个组的父母在家中与儿童一起进行诸如阅读和做数学题的共同活动的频次与质量上表现出差异。 相似文献
646.
大学生人格、社会支持与主观幸福感的关系 总被引:7,自引:0,他引:7
采用问卷调查法探讨了大学生的主观幸福感与人格、社会支持的关系。研究发现:(1)大学生的主观幸福感无性别差异;(2)不同人格类型的大学生的主观幸福感水平有显著的差异:多血质者主观幸福感最高,抑郁质者最低;(3)四种人格类型大学生的主观幸福感均有随社会支持水平的增加而增加的趋势;(4)神经质、外向性和家庭外源性社会支持对主观幸福感有较强的预测力;但外向性与主观幸福感的关系将在一定程度上以家庭外源性社会支持为中介。 相似文献
647.
利用亲社会性视频游戏和IAT测验,从内隐社会认知的角度研究亲社会性视频游戏对高中生内隐攻击性认知的影响,并分析影响是否具有性别差异和攻击特质差异。结果表明:(1)亲社会性视频游戏对高中生内隐攻击性认知的抑制效应显著;(2)游戏类型和性别对内隐攻击性认知的交互作用显著,亲社会性视频游戏更容易对女生的内隐攻击性认知产生抑制效应;(3)攻击特质对高中生的内隐攻击性认知的主效应显著,并且游戏类型和攻击特质对高中生内隐攻击性认知的交互作用显著,亲社会性视频游戏更容易对低攻击特质学生产生抑制效应。由此可见,亲社会性视频游戏能够有效抑制高中生的内隐攻击性认知水平。 相似文献
648.
大学生成就目标与主观幸福感的关系研究 总被引:2,自引:1,他引:1
目的:探讨大学生成就目标与主观幸福感的关系。方法:采用成就目标量表、主观幸福感量表整群抽样调查247名大学生。结果:①来自乡村的大学生的掌握目标显著高于来自城镇的大学生,女生的成绩回避目标显著高于男生。②掌握目标与积极情感显著正相关,与消极情感显著负相关;成绩接近目标与生活满意度、积极情感显著正相关;成绩回避目标与消极情感显著正相关。③掌握目标正向预测积极情感,负向预测消极情感;成绩接近目标正向预测生活满意度和积极情感;成绩回避目标正向预测消极情感,负向预测积极情感。结论:掌握目标和成绩接近目标有利于主观幸福感,成绩回避目标不利于主幸福感。 相似文献
649.
Hang Jin Jo Daniela Mattos Elisabeth B. Lucassen Xuemei Huang 《Journal of motor behavior》2017,49(2):218-228
The authors explored the changes in multidigit synergies in patients with multiple sclerosis (MS) within the framework of the uncontrolled manifold hypothesis. The specific hypotheses were that both synergy indices and anticipatory synergy adjustments prior to the initiation of a self-paced quick action would be diminished in the patients compared to age-matched controls. The MS patients and age-matched controls (n = 13 in both groups) performed one-finger and multifinger force production tasks involving both accurate steady-state force production and quick force pulses. The patients showed significantly lower maximal finger forces and a tendency toward slower force pulses. Enslaving was increased in MS, but only in the lateral fingers (index and little). Indices of multifinger synergies during steady-state force production were lower in MS, mainly due to the lower amount of intertrial variance that did not affect total force. Anticipatory synergy adjustments were significantly delayed in MS. The results show that MS leads to significant changes in multidigit synergies and feed-forward adjustments of the synergies prior to a quick action. The authors discuss possible contributions of subcortical structures to the impaired synergic control. 相似文献
650.
Taeyong Sim Hakje Yoo Ahnryul Choi Ki Young Lee Mun-Taek Choi Soeun Lee 《Journal of motor behavior》2017,49(6):668-674
The aim of this research was to quantify the coordination pattern between thorax and pelvis during a golf swing. The coordination patterns were calculated using vector coding technique, which had been applied to quantify the coordination changes in coupling angle (γ) between two different segments. For this, fifteen professional and fifteen amateur golfers who had no significant history of musculoskeletal injuries. There was no significant difference in coordination patterns between the two groups for rotation motion during backswing (p = 0.333). On the other hand, during the downswing phase, there were significant differences between professional and amateur groups in all motions (flexion/extension: professional [γ] = 187.8°, amateur [γ] = 167.4°; side bending: professional [γ] = 288.4°, amateur [γ] = 245.7°; rotation: professional [γ] = 232.0°, amateur [γ] = 229.5°). These results are expected to be a discriminating measure to assess complex coordination of golfers' trunk movements and preliminary study for interesting comparison by golf skilled levels. 相似文献