Gait and risk of falls associated with frontal cognitive functions at different stages of Alzheimer's disease

ABSTRACT The decline in frontal cognitive functions contributes to alterations of gait and increases the risk of falls in patients with dementia, a category which included Alzheimer's disease (AD). The objective of the present study was to compare the gait parameters and the risk of falls among patients at different stages of AD, and to relate these variables with cognitive functions. This is a cross-sectional study with 23 patients with mild and moderate AD. The Clinical Dementia Rating was used to classify the dementia severity. The kinematic parameters of gait (cadence, stride length, and stride speed) were analyzed under two conditions: (a) single task (free gait) and (b) dual task (walking and counting down). The risk of falls was evaluated using the Timed Up-and-Go test. The frontal cognitive functions were evaluated using the Frontal Assessment Battery (FAB), the Clock Drawing Test (CDT) and the Symbol Search Subtest. The patients who were at the moderate stage suffered reduced performance in their stride length and stride speed in the single task and had made more counting errors in the dual task and still had a higher fall risk. Both the mild and the moderate patients exhibited significant decreases in stride length, stride speed and cadence in the dual task. Was detected a significant correlation between CDT, FAB, and stride speed in the dual task condition. We also found a significant correlation between subtest Similarities, FAB and cadence in the dual task condition. The dual task produced changes in the kinematic parameters of gait for the mild and moderate AD patients and the gait alterations are related to frontal cognitive functions, particularly executive functions.     

Age-related differences in word-retrieval but not in meaning generation

This study examines age-associated changes in retrieval on a picture-naming task, phonemic and semantic fluency tasks, and the Homophone Meaning Generation Test (HMGT). The sample included 152 Hebrew-speaking adults, half young (mean age 22.75) and half old (mean age 76.05). Groups differed on the picture-naming task and on both verbal fluency tasks, but not on the HMGT. Age explained a greater share of the variance than did education level on these three tests, whereas the opposite pattern of results was seen on the HMGT. We suggest that age-related word finding difficulties are attenuated when performance allows for semantic rather than phonological access.     

What is Psychological Well-Being, Really? A Grassroots Approach from the Organizational Sciences

Research on psychological well-being (PWB) in organizational settings is now facing two major challenges. First, conceptual confusion surrounds PWB (Danna and Griffin 1999; Diener 1994; Ryff 1989), and the debate about the superiority of concurrent hedonic, eudaimonic, and integrative approaches is still open. Second, researchers in the organizational sciences mainly study context-free PWB while measuring organizational correlates, despite contextualized non-cognitive measures having proven their incremental validity over context-free measures (e.g. English 2001; Hunthausen et al. 2003). In an attempt to address these issues from a new perspective, an inductive approach was proposed. To confer good content validity to our model of PWB at work (PWBW), a preliminary bottom-up qualitative phase was carried out. On this basis, a quantitative study was conducted. From the 80 manifestations of PWBW obtained, a new instrument was generated and administered to 1,080 workers, supplemented by measures of context-free PWB and distress, of positive and negative affect, and of life satisfaction. Exploratory factor analyses revealed that PWBW can be conceptualized through 5 dimensions, namely, Interpersonal Fit at Work, Thriving at Work, Feeling of Competency at Work, Desire for Involvement at Work, and Perceived Recognition at Work. The questionnaire showed satisfactory internal consistency. Correlational analyses support the “related but distinct” nature of PWBW with regard to context-free hedonic and eudaimonic PWB dimensions and psychological distress indicators. In sum, the study led to the development of a grounded conceptualization of PWBW based on a work frame-of-reference and tied to a reliable and valid measure.     

Measuring Non-Economic Quality of Life on a Sub-National Level: A Case Study of New Zealand

Most research on non-economic quality of life has a national focus and/or uses subjective measures. This paper makes use of a multitude of demographic and geographic variables to construct objective indices of quality of life. This analysis is applied at the sub-national level for New Zealand for the purpose of rating regional areas on their quality of life over the period of 1986?C2006. This study also makes a contribution to the current quality of life literature by using a regression technique to remove the impact of income levels and therefore focus on the non-economic component of these quality of life indices. Our results show that Taranaki and Nelson are doing much better in terms of their quality of life, and Bay of Plenty and Waikato much worse than expected, given their levels of regional GDP per capita. These results have important policy implications at the regional council level.     

The learning and motor development transfer process

The aim of this study is to analyze the transference process in motor skill learning. For this purpose, 320 boys and girls, with ages ranging from 3 to 12 years (M= 7.61; SD= 2.61), took part in nine object movement reception drills in which the following variables were cross-examined: the presence-absence of displacement (static or in motion), the corporal segments utilized (hands or arms), the movement direction (right or left), and the moving object (volleyball or tennis ball). The results indicate that what is being transferred is the common factor among them, the ocular-kinesthetic regulating system, which is constructed according to a generalized motor program and a predictive strategy of continuous control. The way that individuals group by levels of skill that represent the developmental levels of the aforementioned regulating system can also be observed. Lastly, the results are discussed, and strategies to improve the learning process in sports and physical education are provided.     

Pleasant emotional induction broadens the visual world of young children

These experiments aimed at studying the influence of emotional context on global/local visual processing in children. Children 5 years old, known to present an immature global visual bias, and 8 years old, known to pay attention predominantly to global information, were placed in either a neutral or pleasant emotional context and subsequently presented with a global/local visual judgement task. As with previous findings for adults, both age groups presented a pronounced perceptual bias toward global information following exposure to emotionally pleasant pictures. Interestingly, younger children, who do not present a global bias during the neutral exposure, presented the same preference for global information as older children when exposed to the pleasant context. These findings indicate that emotion may strongly affect visual perception in children, with important implications for educational practice and models of cognition.     

Event-related EEG oscillations to semantically unrelated words in normal and learning disabled children

Learning disabilities (LD) are one of the most frequent problems for elementary school-aged children. In this paper, event-related EEG oscillations to semantically related and unrelated pairs of words were studied in a group of 18 children with LD not otherwise specified (LD-NOS) and in 16 children with normal academic achievement. We propose that EEG oscillations may be different in LD NOS children versus normal control children that may explain some of the deficits observed in the LD-NOS group. The EEGs were recorded using the 10/20 system. EEG segments were edited by visual inspection 1000ms before and after the stimulus, and only correct responses were considered in the analysis. Time-frequency (1-50Hz) topographic maps were obtained for the increases and decreases of power after the event with respect to the pre-stimulus average values. Significant differences between groups were observed in the behavioral responses. LD-NOS children show less number of correct responses and more omissions and false alarms than the control group. The event-induced EEG responses showed significant differences between groups. The control group showed greater power increases in the frequencies 1-6Hz than the LD-NOS group from 300 to 700ms. These differences were mainly observed in frontal regions, both to related and non-related words. This was interpreted as a deficit in attention, both to internal and external events, deficits in activation of working memory and deficits in encoding and memory retrieval in the LD-NOS children. Differences between groups were also observed in the suppression of alpha and beta rhythms in the occipital regions to related words in frequencies between 8 and 17Hz from 450 to 750ms. LD-NOS children showed shorter durations of the decreases in power than the control group. These results suggest also deficits in attention and memory retrieval. It may be concluded that LD-NOS children showed physiological differences from normal children that may explain their cognitive deficiencies.     

Phenotypic expression of schizotypal traits in an adolescent population

The main goal of the present study was to examine the influence of gender and age in the phenotypic expression of schizotypal traits in a community sample of adolescents. The sample was composed of a total of 1,618 participants, 776 (48%) males, with a mean age of 15.9 years (SD = 1.2). The ESQUIZO-Q: Oviedo Schizotypy Assessment Questionnaire was used for the assessment of schizotypal traits, a measure specifically developed for its use in adolescents. The results showed that gender and age were two sociodemographical variables that influenced the expression of schizotypal features. The males in the study obtained higher mean scores than the females in the Negative dimension (Physical and Social Anhedonia); however, the females obtained higher mean scores in Magical Thinking, Lack of Close Friends, and Social Disorganization. With regard to age, the younger adolescents had lower scores in Odd Thinking and Language, Lack of Close Friends, Excessive Social Anxiety, and Social Disorganization compared to the older adolescents. This differential pattern is similar to the one found in patients with schizophrenia and in nonclinical young adults, and these findings improve our understanding about the phenotypic expression of schizotypy during adolescence.     

Life aspirations,personality traits and subjective well‐being in a Spanish sample

This study examines the relationships between intrinsic/extrinsic aspirations and subjective well‐being (SWB; positive affect, negative affect, satisfaction with life) in a sample of 583 Spanish adults. Firstly, the results showed that high scores for SWB are related to high scores for intrinsic aspirations and, to a lesser extent, to low scores for extrinsic aspirations; it was also found that intrinsic aspirations are mainly related to positive indicators of well‐being, whereas extrinsic aspirations are mainly associated with negative indicators. Secondly, the study also enabled exploration of the links between the domains of the Five‐Factor Model and aspirations; thirdly, the results showed that intrinsic/extrinsic aspirations predict SWB beyond the Five Factors. The results demonstrate the importance of studying the content of human aspirations for understanding psychological health. Copyright © 2011 John Wiley & Sons, Ltd.     

Decision making cognition in primary progressive aphasia

We sought to investigate the decision making profile of Primary Progressive Aphasia (PPA) by assessing patients diagnosed with this disease (n = 10), patients diagnosed with behavioral variant frontotemporal dementia (bvFTD, n = 35), and matched controls (n = 14) using the Iowa Gambling Task, a widely used test that mimics real-life decision making. Participants were also evaluated with a complete neuropsychological battery. Patients with PPA were unable to adopt an advantageous strategy on the IGT, which resulted in a flat performance, different to that exhibited by both controls (who showed advantageous decision making) and bvFTD patients (who showed risk-appetitive behavior). The decision making profile of PPA patients was not associated with performance on language tasks and did not differ between sub-variants of the disease (namely, semantic dementia and progressive nonfluent aphasia). Investigating decision making in PPA is crucial both from a theoretical perspective, as it can shed light about the way in which language interacts with other cognitive functions, as well as a clinical standpoint, as it could lead to a more objective detection of impairments of decision making deficits in this condition.