An Investigation of Genetic Counselors’ Testing Recommendations: Pedigree Analysis and the Use of Multiplex Breast Cancer Panel Testing

Genetic testing recommendations for hereditary breast and ovarian cancer involve pedigree analysis and consultation of testing guidelines. The testing landscape for hereditary cancer syndromes is shifting as multiplex panel tests become more widely integrated into clinical practice. The purpose of the current study was to assess how genetic counselors utilize pedigrees to make recommendations for genetic testing, to determine consistency of these recommendations with National Comprehensive Cancer Network (NCCN) Guidelines and to explore current use of multiplex panel testing. Sixty-nine genetic counselors were recruited through the National Society of Genetic Counselors Cancer Special Interest Group’s Discussion Forum. Participation involved pedigree analysis and completion of an online questionnaire assessing testing recommendations and use of multiplex panel testing. Pedigree analysis and test recommendations were scored for consistency with NCCN guidelines. The average score was 12.83/15 indicating strong consistency with NCCN guidelines. Participants were more likely to consider multiplex testing when pedigrees demonstrated highly penetrant dominant inheritance but were not indicative of a particular syndrome. Participant concerns about multiplex panel testing include limited guidelines for both testing eligibility and medical management. This study demonstrates high utilization of pedigree analysis and raises new questions about its use in multiplex genetic testing.     

The effect of comparative context on evaluative conditioning

Evaluative conditioning (EC) is a change in the evaluation of a stimulus after the stimulus co-occurred with affective stimuli. The present research examined whether EC of one stimulus depends also on the co-occurrence of another stimulus with positive or negative stimuli. We paired two target people with affective stimuli. We found that a person who appeared eight times with positive stimuli and eight times with negative stimuli was liked more when the other person appeared always (16 times) with negative stimuli than when the other person appeared always with positive stimuli. The manipulation did not change the US evaluation or the general standard on the value dimension of what a positive or negative stimulus is. We suggest that like other evaluative traits (e.g., evil, pretty) co-occurrence with affective stimuli is sensitive to temporary standards. The manipulation changed the standard of what co-occurrence with affective stimuli is considered positive versus negative.     

Leader performance and prototypicality: Their inter‐relationship and impact on leaders' identity entrepreneurship

Research has demonstrated that leader performance and leader prototypicality are both predictors of leader endorsement. While performance and prototypicality have generally been considered to be independent, this paper suggests that performance and prototypicality are interdependent and have a bi‐directional impact both on each other and on leaders' capacity to engage in identity entrepreneurship (i.e., to define shared group norms and ideals). Two experimental studies indicate that followers infer leaders' prototypicality from their performance and that a leader's prototypicality determines perceptions of performance (indicating reversed causality). Moreover, there is evidence that both performance and prototypicality enhance leaders' capacity to act as identity entrepreneurs. These findings extend our understanding of the mutually dependent causal relationship between followers' perceptions that a leader is ‘one of us’ and that he or she is ‘doing it well’. They also provide the first experimental evidence that these factors are joint determinants of leaders' identity entrepreneurship. Copyright © 2013 John Wiley & Sons, Ltd.     

General Mental Ability and pay: Nonlinear effects

While many studies have examined the linear relationship between intelligence and economic success, only few, if any, examined their nonlinear relationships. The current study examines such relationships in a large, nationally representative sample, using pay as an indicator of economic success. The results show that the effect of General Mental Ability (GMA) on pay depends on occupational complexity; the greater the complexity, the stronger the effect. They also show that, by and large, there is a marginally decreasing (concave) effect of GMA on pay. Methodological and practical questions concerning the relationship between cognitive ability and pay are discussed.     

On intelligence education and religious beliefs

A number of authors have suggested that education mediates the negative effect of intelligence on religiosity. However, there is very little direct evidence for this mediation, and the indirect evidence is contradictory. The results of the current paper suggest that, by and large, education does not mediate the effect of intelligence on religiosity. However, the results also suggest that since education has a positive effect on religiosity when religious background is strong and a negative effect when religious background is weak, and since intelligence has a positive effect on education, the negative effect of intelligence on religiosity is stronger when religious background is strong than when it is weak. We examine this mediated moderation model in two large, nationally representative, databases.     

Intelligence and religiosity: Within families and over time

We study the effect of intelligence (General Mental Ability) on religiosity using research designs that allow for stronger causal inferences compared to previous research in this area. First, we examine how between-siblings differences in intelligence are related to differences in their religiosity. Second, we examine how intelligence is related to changes in religiosity over time. The results of both designs suggest that intelligence has a strong negative effect on religiosity. In addition, our results also suggest that intelligence interacts with age in determining religiosity: the more intelligent the person, the stronger the negative effect of age on religiosity.     

Negotiation as a form of persuasion: arguments in first offers

In this article we examined aspects of negotiation within a persuasion framework. Specifically, we investigated how the provision of arguments that justified the first offer in a negotiation affected the behavior of the parties, namely, how it influenced counteroffers and settlement prices. In a series of 4 experiments and 2 pilot studies, we demonstrated that when the generation of counterarguments was easy, negotiators who did not add arguments to their first offers achieved superior results compared with negotiators who used arguments to justify their first offer. We hypothesized and provided evidence that adding arguments to a first offer was likely to cause the responding party to search for counterarguments, and this, in turn, led him or her to present counteroffers that were further away from the first offer.     

Conditions for growth in one-person startups: a longitudinal study spanning eight years

In the European Union, one-person businesses (OPBs) are increasingly regarded as an important alternative to dependent employment. From an economic policy standpoint, the growth potential of such businesses is especially attractive. This paper analyzes the growth potential of OPBs by postulating five key groups of enterprise growth predictors: personal traits, resources, strategy, industry, and organizational structures and systems. The framework model was adapted to suit the specific circumstances of OPBs. The model was tested using a longitudinal data set comprising 188 OPBs which were observed over a period of eight years. At the end of the observation period, the OPBs included in the study had an average of 1.33 employees. The gender of the founder, capital requirements at the time of establishment, and growth strategy proved to be the most important predictors of growth. In addition, human capital resources also tended to have a positive impact. The traits of the person founding the business were not found to affect growth. In summary, it is possible to draw empirically reliable conclusions about growth potential on the basis of the ?seriousness? of an OPB startup project.