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11.
采用细胞因子刺激剂脂多糖(lipopolysaccharide, LPS)为免疫激活手段, 研究LPS诱导的免疫激活产生的抑郁样行为及对海马神经细胞电压依赖钾电流变化的影响。应用膜片钳技术对海马神经细胞钾电流进行全细胞记录, 比较抑郁样行为大鼠与正常大鼠钾离子通道电流密度和激活特性的变化。结果发现, 与生理盐水对照组相比, 一次LPS注射后2 hr, 实验组动物产生抑郁样行为, 同时急性观察的海马神经细胞的钾离子通道的电流密度呈现显著升高(p<0.01); 而一次LPS注射后24 hr, 动物的抑郁样行为消失, 且急性观察的海马神经细胞的钾离子通道与对照组相比较, 其电流密度和激活曲线没有显著性变化。结论:LPS诱导的抑郁样行为, 与LPS诱导的海马神经细胞电压依赖钾电流的上调在时程上同步, 提示钾离子通道可能参与免疫激活所致的抑郁样行为。 相似文献
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Yin Dake Yu Jiangping Jin Jiangping Shen Chao Zhang Li Li Xudong Zhang Keqin Wang Haitao 《Animal cognition》2023,26(4):1423-1430
Animal Cognition - Birds have the ability to assess the risk of predation in their environment and adjust their antipredation strategies based on this risk information. However, whether nest site... 相似文献
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Yin‐Hui Cheng Molly C.‐J. Huang Shih‐Chieh Chuang Ying Rung Ju 《International journal of psychology》2015,50(5):345-353
We conducted three studies to investigate indulgent choice in settings with and without impression management by public–private manipulation with evaluation. Study 1 showed that the participants were less indulgent under public scrutiny due to the employment of impression management. Study 2 focused on the impression management context to test the moderate effect of self‐consciousness in two impression managed contexts. Study 3 focused on context without impression management to test the moderate effects of self‐awareness on choices. We found that depending on differences in primed personality, individuals tended to make choices other than those they favoured privately when anticipating that others might form impressions of them based on the decisions made. The findings of all three studies support our basic prediction that people are less indulgent under impression management and suggest that people tend to manage their impression by eating healthier (less indulgently) in public. 相似文献
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建构水平理论(Construal level theory)认为时间能够独立地改变评价对象的建构水平,从而对对象的不同特征赋予不同的权重。个体倾向于用抽象的整体的特征表征时距远的事物,而用具体的局部的特征表征时距近的事物。空间距离不同的评价对象是否也遵循同样的规律?在考察时空距离与个人相关性的基础上,通过2(时间距离:明天和十年后)×2(空间距离:近地点和远地点)×2(特征类型:样例特征和类型特征)三因素被试间实验设计,探讨时间距离、空间距离、特征类型对态度的影响。结果发现,空间距离影响人们对事物的态度。在远空间距离水平上,时间距离对态度的影响显著,而在近空间距离水平上时间距离对态度的影响不显著;在远空间条件下,时距远的对象优先注意类型化的特征,时距近的对象优先注意样例化特征。最后,在建构水平理论框架内讨论了实验结果。 相似文献
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Kim Yin Chan Moon-ho R. Ho Oleksandr S. Chernyshenko Olwen Bedford Marilyn A. Uy David Gomulya Y.L. Sam Wei Ming J. Phan 《Journal of Vocational Behavior》2012,81(1):73-88
We propose a person-centered framework for conceptualizing subjective careers in an increasingly boundaryless work context. Specifically, we argue that entrepreneurship, professionalism, and leadership (EPL) can serve as three key dimensions of subjective career space. We relate this framework to earlier macro-level national and organizational career models proposed by Kanter (1989) and Schein (1978). Our empirical study involving 10,326 Singaporean university students demonstrated that entrepreneurial, professional, and leadership career aspirations (including motivations, efficacies, and intentions) can be measured independently, that these career dimensions are independent of vocational interests, and that they are to some degree viewed as competing career alternatives. We also show that EPL motivation profiles can operationalize the boundaryless and protean career concepts. Individuals concurrently high in entrepreneurial, professional, and leadership career motivations, and those high in entrepreneurial and leadership motivations are highest in boundaryless and self-directed career attitudes, while those primarily motivated for professional careers hold the most traditional career attitudes. We conclude by discussing the potential of the framework for understanding human resource issues at organizational and national levels and for enhancing the study of entrepreneurship, professionalism, and leadership. 相似文献
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On Zhi Xiang Ryan Nicholas P. Konjarski Monika Catroppa Cathy Stargatt Robyn 《Neuropsychology review》2022,32(1):127-148
Neuropsychology Review - Recent evidence suggests social cognitive deficits may be among the most profound and disabling consequences of childhood traumatic brain injury (TBI); however, it is only... 相似文献
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Personality is hypothesized to have direct and indirect effects on health-related quality of life (HRQoL) through the mediating role of perceived occupational stressors. This hypothesized model was tested with Chinese judges, individuals characterized by high occupational stress. In this cross-sectional study, 330 judges undergoing professional training at the Shandong Judge Training Institute completed questionnaires assessing their personality (Big Five Inventory, BFI), perceived occupational stressors (Occupational Role Questionnaire, ORQ), and HRQoL (Medical Outcomes Study Short-Form Health Survey, SF-36). The proposed model was tested using structural equation modelling (SEM) approaches. The SEM analysis showed a good fit of the data to the hypothesized model(x 2/df = 1.52, P?0.001, RMSEA = 0.04, GFI = 0.87, CFI = 0.91, TLI = 0.89). The model explained 60 % of the variance in HRQoL. A strong negative direct effect of neuroticism on HRQoL (?0.50, P?0.01) was observed. Neuroticism also had a negative indirect effect (?0.18, P?0.01) on HRQoL by positively influencing (β?=?0.47, P?0.01) perceived occupational stressors which had significantly negative direct effects (β?=??0.39, P?0.01) on HRQoL. However, both the direct effects of openness, conscientiousness, agreeableness and extraversion on HRQoL and their indirect effects mediated by perceived occupational stressor were not significant. In conclusion, our hypotheses were partly supported by the data. We found that neuroticism had both direct effect on HRQoL and an indirect effect through the mediating role of perceived occupational stressors which also had a significant effect on HRQoL, whereas neither the direct nor the indirect effects of openness, conscientiousness, agreeableness and extraversion on HRQoL of Chinese judges had been found in current study. 相似文献
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