Mechanism of isoflavone aglycone's effect on cognitive performance of senescence-accelerated mice

This study investigated the effect of isoflavone aglycone (IA) on the learning and memory performance of senescence-accelerated mice, and explored its neural protective mechanism. Results showed that SAM-P/8 senescence-accelerated mice treated with IA performed significantly better in the Y-maze cognitive test than the no treatment control (P<0.05). The cortex AchE activity, serum SOD and GSH-Px activities were notably higher (P<0.05). MDA concentration and the β-secretase activity in the hippocampal tissue were both lower (P<0.05). Additionally, the number of hippocampal neurons was increased and cell morphology was significantly improved. Data suggested that IA could indirectly increase concentration of the cholinergic neural transmitter Ach through regulation of AchE, therefore improving the central cholinergic function and enhancing the learning and memory ability. By reducing the β-secretase activity, IA could decrease the formation and deposition of insoluble Adebris, relieve the resulted toxicity and damage to neurons, and thereby effectively protect the nervous system.     

Social Contact,Academic Satisfaction,COVID-19 Knowledge,and Subjective Well-being Among Students at Turkish Universities: a Nine-University Sample

Adverse effects of COVID-19 are seen not only on the physical health of infected individuals but also on their subjective well-being. Sudden changes in social lives, lockdowns, and shifts towards online education have had a negative impact on many people, especially university students. As part of an international study, the current study focused on the well-being of students at Turkish universities in relation to social contact, academic satisfaction, and COVID-19 knowledge. A total of 7363 students from nine universities (86.6% from state universities, 71.04% female, and 73.52% at bachelor’s level) participated in an online survey. Results revealed that females had lower levels of subjective well-being and academic satisfaction. According to a mediation model in the study, the relationship between social contact and well-being was mediated by academic satisfaction and COVID-19 knowledge. Our findings can guide future researchers, mental health professionals, universities, and policymakers to understand and improve subjective well-being of university students.

     

反映还是形成？平行还是层级？PSM的模型建构与检验

在心理学领域,传统的多指标潜变量的测量模型大都采用反映性建构,各指标反映了潜在构念,构念是各指标的原因.但实际上有些构念应该采用形成性建构,各指标是原因,形成了潜在构念.建构方式的选择不仅要从理论来考虑,还要通过数据特征来决定.研究以公共服务动机（PSM）构念为例,通过公益投资游戏取得投资绩效和满意度效标,验证了先前研究提出的“一阶反映二阶形成”建构模式,并进一步检验了层级性建构方式的优势,有助于PSM理论框架与实证测量的统一.     

论道德临界空间

道德临界空间是道德善恶发生质态转化的空间场域。道德主体根据自己能够承受的恶的极限与善的极限设置临界空间的道德边界,通过内隐约定维持道德临界空间的结构完整。道德临界空间是价值空间、契约空间和博弈空间,呈现出公共性与私人性、同位性与错位性、对称性与非对称性的空间样态,临界空间中善的临界点与恶的临界点的空间位置,表征着主体的道德境界与道德水平。道德临界空间为主体提供了可以量度的道德行动边界,让主体在不突破对象性主体临界点的道德选择中获得自由的道德生长。可以说,共同体道德秩序的建构就是维持道德临界空间的平衡,通过提升主体的利益计较值、关系亲密度及价值契合度,最大限度克服善恶主观性对道德临界点精确定位的空间制约,依特定道德情景压缩或拓展道德临界空间,是促进社会道德和谐的必然选择。     

Development of a facial-expression database of Chinese Han,Hui and Tibetan people

Recently, cross-cultural facial-expression recognition has become a research hotspot, and a standardised facial-expression material system can significantly help researchers compare and demonstrate the results of other studies. We developed a facial-expression database of Chinese Han, Hui and Tibetan ethnicities. In this study, six basic human facial expressions (and one neutral expression) were collected from 200 Han, 220 Hui and 210 Tibetan participants who lived in these regions. Four experts on each ethnicity evaluated the facial-expression images according to the expressions, and only those achieving inter-rater agreement were retained. Subsequently, 240 raters evaluated these images according to the seven emotions and rated the intensity of the expressions. Consequently, 2980 images were included in the database, including 930 images of Han individuals, 962 images of Hui individuals and 1088 images of Tibetan individuals. In conclusion, the facial-expression database of Chinese Han, Hui and Tibetan people was representative and reliable with a recognition rate of over 60%, making it well-suited for cross-cultural research on emotions.     

Nostalgia and Temporal Life Satisfaction

Recent research has shown that nostalgia, an apparently past-oriented emotion, may render the present self more positive and promote a brighter outlook on the future. The current study examined whether experimentally induced nostalgia would impact the levels of and associations among past, present, and future life satisfaction. Among 250 university students (86 males and 164 females, aged 16–26 years), nostalgia was manipulated through the recollection of nostalgic (vs. ordinary) events. In support of our hypotheses, the results showed that nostalgic experiences not only led to a larger contrast between past life satisfaction versus present and future life satisfaction, but also weaker associations between past and future life satisfaction and between present and future life satisfaction. Overall, the findings suggest that nostalgic experiences can render more distinct judgements on temporal life satisfaction.     

道德信息对面孔吸引力判断的无意识调节

抽象语言信息是否能够影响知觉?本研究在审美领域对此进行考察,探索无意识获取的道德信息是否影响个体对相应面孔吸引力的知觉判断。结果发现个体对面孔吸引力的知觉判断受到内隐道德信息的调节,且调节效应与面孔本身吸引力水平无关; 另外,面孔审美判断的反应时受到道德美丑和面孔吸引力的共同影响,尤其当两类信息相矛盾时被试需要更长的时间进行判断。研究结果表明抽象的社会道德信息可以对面孔吸引力的知觉判断产生自上而下的调节。     

Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.

Design: A cross-sectional design with gene-environment interaction (G?×?E) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.

Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.

Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.     

Health-Related Quality of Life in a Low-Socioeconomic Status Public Rental-Flat Population in Singapore

Health-related quality of life (HRQoL) is a well-established measure of health and general well-being. Socioeconomic status (SES) can affect HRQoL. We sought to determine whether there were differences in HRQoL between low versus higher area-SES flat communities in Singapore. Residents in two integrated public housing precincts comprising of rental-flat blocks (low area-SES neighborhood) and neighboring owner-occupied blocks (higher area-SES neighborhood) were asked to rate their self-perceived HRQoL using the EuroQol Group five dimensions (EQ-5D) instrument. The EQ-5D assesses HRQoL in five domains (mobility, self-care, usual activities, anxiety/mood and pain) and with a global visual analogue scale (EQ-VAS). We evaluated differences in HRQoL between the rental and owner-occupied neighborhoods, and factors associated with anxiety/depression in the rental-flat neighborhood using multivariate logistic regression. The participation rate was 89.1% (634/711). In the owner-occupied neighborhood, 56.7% (216/381) were in full health, compared with 54.2% (137/253) in the rental-flat population (OR = 0.90, 95%CI = 0.66–1.24, p = 0.568). Across the five domains, staying in a rental-flat neighborhood was independently associated with anxiety/depression (adjusted odds ratio [aOR] = 1.79, 95%CI = 1.10–2.92, p = 0.019). In the rental-flat population, having anxiety/depression was independently associated with minority ethnicity, problems with self –care, pain/discomfort, difficulty with healthcare costs, and not being on subsidized primary care (p < 0.05). There was no significant difference on the EQ-VAS between the two neighborhoods (p = 0.627). Staying in a low area-SES neighborhood was associated with more mental health problems. In the rental-flat population, self-reported anxiety/depression was associated with minority ethnicity, physical health problems, and financial disadvantage in healthcare.