Reevaluating the role of the medial prefrontal cortex in delay eyeblink conditioning

It has been proposed that the medial prefrontal cortex (mPFC) is not necessary for delay eyeblink conditioning (DEC). Here, we investigated the involvement of the mPFC in DEC with a soft or loud tone as the conditioned stimulus (CS) by using electrolytic lesions or muscimol inactivation of guinea pig mPFC. Interestingly, when a soft tone was used as a CS, electrolytic lesions of the mPFC significantly retarded acquisition of the conditioned response (CR), and muscimol infusions into mPFC distinctly inhibited the acquisition and expression of CR, but had no significant effect on consolidation of well-learned CR. In contrast, both electrolytic lesions and muscimol inactivation of mPFC produced no significant deficits in the CR when a loud tone was used as the CS, or in the unconditioned response (UR) when a soft or loud tone was used as the CS. These results demonstrate that the mPFC is essential for the DEC with the soft tone CS but not for the DEC with the loud tone CS.     

G(o) activation is required for both appetitive and aversive memory acquisition in Drosophila

Heterotrimeric G(o) is an abundant brain protein required for negatively reinforced short-term associative olfactory memory in Drosophila. G(o) is the only known substrate of the S1 subunit of pertussis toxin (PTX) in fly, and acute expression of PTX within the mushroom body neurons (MB) induces a reversible deficit in associative olfactory memory. We demonstrate here that the induction of PTX within the α/β and γ lobe MB neurons leads to impaired memory acquisition without affecting memory stability. The induction of PTX within these MB neurons also leads to a significant defect in an optimized positively reinforced short-term memory paradigm; however, this PTX-induced learning deficit is noticeably less severe than found with the negatively reinforced paradigm. Both negatively and positively reinforced memory phenotypes are rescued by the constitutive expression of G(o)α transgenes bearing the Cys(351)Ile mutation. Since this mutation renders the G(o) molecule insensitive to PTX, the results isolate the effect of PTX on both forms of olfactory associative learning to the inhibition of the G(o) activation.     

Violence risk: Re-defining variables from the first-person perspective

Over the past 25 years, there have been notable advances in violence risk assessment of mentally ill individuals using actuarial methods to define high versus low risk groups. A focus on readily observable risk factors, however, has led to a relative neglect of how the offender's subjective states may be valuable to consider in research on the ongoing assessment and prevention of violence. We argue for the relevance of considering idiographic features of subjective experience in the development of structured assessment methods. We then identify three heuristic groups of existing constructs related to aggressive and illegal behavior that may capture modifiable, time-varying aspects of mental functioning leading up to involvement in an act of violence. These hypothesized domains are: (i) construal of intent and cause; (ii) normative reference points; and (iii) emotion recognition and regulation. We suggest that risk state for violence can be studied in a parsimonious and direct manner through systematic research on coded speech samples. The coding method for such an assessment procedure would be almost identical to existing structured clinical judgment instruments with the difference that variables be defined from a first-person point of view. Some implications of this approach for the tertiary prevention of violence in high-risk individuals are described.     

Neural mechanisms underlying the higher levels of subjective well-being in extraverts: Pleasant bias and unpleasant resistance

The present study investigated the neural mechanisms that underlie the higher levels of subjective well-being in extraverts. The impact of extraversion on the human sensitivity to pleasant and unpleasant pictures of diverse emotional intensities was examined. We recorded event-related potentials (ERPs) for highly positive (HP), moderately positive (MP), and neutral stimuli in the pleasant session, and for highly negative (HN), moderately negative (MN), and neutral stimuli in the unpleasant session, while subjects (16 extraverts and 16 ambiverts) performed a standard/deviant categorization task, irrespective of the emotionality of the deviant stimuli. The results showed significant emotion effects for HP and MP stimuli at the P2 and P3 components in extraverts, but not in ambiverts. Despite a pronounced emotion effect for HN stimuli across the P2, N2, and P3 components in both samples, ambiverts displayed a significant emotion effect for MN stimuli at the N2 and P3 components that was absent in extraverts. The posterior cingulate cortices, which connect multiple neural regions that are important in interactions of emotion and extraversion, may mediate the extravert-specific emotion effect for pleasant stimuli. Thus, extraverts are less susceptible to unpleasant stimuli of mild intensity than are ambiverts, while extraverts have an additional enhanced sensitivity to pleasant stimuli, regardless of emotion intensity. Consequently, the decreased threshold for pleasant emotion and the increased threshold for unpleasant emotion might be essential neural mechanisms that underlie the higher levels of subjective well-being in extraverts.     

Formally grounding spatio-temporal thinking

To navigate through daily life, humans use their ability to conceptualize spatio-temporal information, which ultimately leads to a system of categories. Likewise, the spatial sciences rely heavily on conceptualization and categorization as means to create knowledge when they process spatio-temporal data. In the spatial sciences and in related branches of artificial intelligence, an approach has been developed for processing spatio-temporal data on the level of coarse categories: qualitative spatio-temporal representation and reasoning (QSTR). Calculi developed in QSTR allow for the meaningful processing of and reasoning with spatio-temporal information. While qualitative calculi are widely acknowledged in the cognitive sciences, there is little behavioral assessment whether these calculi are indeed cognitively adequate. This is an astonishing conundrum given that these calculi are ubiquitous, are often intended to improve processes at the human-machine interface, and are on several occasions claimed to be cognitively adequate. We have systematically evaluated several approaches to formally characterize spatial relations from a cognitive-behavioral perspective for both static and dynamically changing spatial relations. This contribution will detail our framework, which is addressing the question how formal characterization of space can help us understand how people think with, in, and about space.     

家庭近乎完美量表中文版的信效度分析

在大学生群体中选取三个样本进行集体施测。选取500名大学生作为样本一,使用家庭近乎完美量表中文版、自尊量表、一般自我效能感量表和Beck抑郁问卷对其施测,对数据进行验证性因素分析、内部一致性信度分析和效标效度分析;六周后在样本一中随机抽取71名大学生作为样本二,使用家庭近乎完美量表对其施测,对数据进行重测信度分析;另选取500名大学生作为样本三,使用家庭近乎完美量表中文版、近乎完美量表修订版的中文修订版和Frost多维完美主义量表对其施测,对数据进行聚合效度和区分效度分析。结果表明,家庭近乎完美量表中文版     

自尊与模糊决策中的决策偏好

从自尊的角度出发,与是否需要承担决策结果的责任相结合,探讨了低自尊、中等自尊和高自尊水平下的被试在模糊决策中的决策偏好。结果发现：角色差异对决策偏好没有影响;自尊水平的高低对决策偏好有影响,高自尊被试与中等、低自尊被试相比,更容易模糊规避。支持了高自尊个体比低自尊个体更具有防御反应的理论。     

一种实用主义的数学哲学观

作者在这篇文论中提出了一种实用主义的数学哲学观。其中的想法是,通过分析各种数学哲学思想对于数学实践的实际影响来比较它们的价值。为解释这种想法的可行性,作者将论证,正是数学的某些特性使得实用主义的方法能够被自然地运用于对数学哲学诸观点的分析。在之后的一节中,作者会给出一些案例分析以展示某些哲学观点是如何具体地影响数学研究的。文章的写作假设读者具备了一些关于经典逻辑和集合论的基础知识。     

Plasticity of inhibition in older adults: Retest practice and transfer effects

This study assessed plasticity of inhibition in older adults through examining retest practice effects in a six-session training paradigm using the Stroop task and the training-induced transfer effects to a range of cognitive measures. Fifty-six older adults (aged 60-84 years, mean = 71.05, standard deviation = 6.17) participated in this study. They were evenly assigned to one of four groups: summary feedback, individualized and adaptive feedback, no-feedback, or a no-contact control group. The results suggest that older adults are able to improve inhibition across retest sessions but unable to transfer the retest practice effects to other tasks. In addition, the improvement is not item specific and feedback does not appear to moderate the magnitude of the training benefits; however, feedback does appear to reduce interference variance across retest practice sessions. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Retest learning in the absence of item-specific effects: Does it show in the oldest-old?

This study examined whether the nonitem-specific retest learning effects, previously shown with young-old adults primarily in their 60s and 70s, could be extended to oldest-old adults aged 80 and onward. Twenty-one oldest-olds participated in an 8-session retest training program with three ability domains: perceptual speed, inductive reasoning, and visual attention. Their data were compared with the data of 30 young-olds collected in a previous work (Yang, Reed, Russo, & Wilkinson, 2009). The two age groups showed largely equivalent retest learning effects. In addition, only young-olds were able to benefit from item-specific retest learning, specifically in reasoning and perceptual speed tests. (PsycINFO Database Record (c) 2012 APA, all rights reserved).