特应性皮炎过敏原的确定

据估计大约50％婴幼儿特应性皮炎和35％成人特应性皮炎患者对常见过敏原过敏。气源性过敏原、食物过敏原和小分子接触性过敏原是特应性皮炎发病的主要环境诱发因素。临床可通过皮肤点刺试验、斑贴试验、特应性斑贴试验等体内试验并结合外周血过敏原特异性IgE检测进行过敏原诊断。当明确与发病相关的过敏原后,回避治疗是首要的原则,对于尘螨等难以完全回避的过敏原,特异性免疫治疗是有可能改善病情并达到长期缓解的治疗手段。     

Effects of psychological interventions for patients with osteoarthritis: a systematic review and meta-analysis

The aim of this study was to determine the effects of psychological interventions (e.g. cognitive restructuring, relaxation) on physiological and psychological health in osteoarthritis patients. A systematic literature search was done using PubMed, Embase, PsycINFO, Web of Science, China National Knowledge Infrastructure, and Wanfang Database through November 2016. Studies were included if they used a randomized controlled trial designed to explore the effects of psychological interventions in osteoarthritis patients. Two independent authors assessed the methodological quality of the trials using criteria outlined by Jadad et al. Meta-analysis was done with the Revman5.0. Twelve randomized controlled trials, including 1307 osteoarthritis patients, met the study inclusion criteria. Meta-analysis showed that psychological interventions could reduce the levels of pain [standard mean difference (SMD) ?0.28, 95% CI ?0.48, ?0.08, P-value 0.005)] and fatigue (SMD ?0.18, 95% CI ?0.34, ?0.01, P-value 0.04). In addition, psychological interventions significantly improved osteoarthritis patients’ self-efficacy (SMD 0.58, 95% CI 0.40, 0.75, P-value 0.00) and pain coping (MD 1.64, 95% CI 0.03, 3.25, P-value 0.05). Although the effects on physical function, anxiety, depression, psychological disability were in the expected direction, they were not statistically significant. In conclusion, the role of psychological interventions in the management of osteoarthritis remains equivocal. Some encouraging results were seen with regard to pain, pain coping, self-efficacy, and fatigue. We believe that more methodologically rigorous large-scale randomized controlled trials are necessary to answer this study question.     

Discrimination threshold for haptic volume perception of fingers and phalanges

Humans exhibit a remarkable ability to discriminate variations in object volume based on natural haptic perception. The discrimination thresholds for the haptic volume perception of the whole hand are well known, but the discrimination thresholds for haptic volume perception of fingers and phalanges are still unknown. In the present study, two psychophysical experiments were performed to investigate haptic volume perception in various fingers and phalanges. The configurations of both experiments were completely dependent on haptic volume perception from the fingers and phalanges. The participants were asked to blindly discriminate the volume variation of regular solid objects in a random order by using the distal phalanx, medial phalanx, and proximal phalanx of their index finger, middle finger, ring finger, and little finger. The discrimination threshold of haptic volume perception gradually decreases from the little finger to the index finger as well as from the proximal phalanx to the distal phalanx. Overall, both the shape of the target and the part of the finger in contact with the target significantly influence the precision of haptic perception of volume. This substantial data set provides detailed and compelling perspectives on the haptic system, including for discrimination of the spatial size of objects and for performing more general perceptual processes.     

3～6岁儿童人格发展的群组序列追踪研究

目的:运用自编幼儿人格发展教师评定问卷对幼儿人格进行追踪测量,探讨其年龄及性别发展特点。方法:用整群抽样法选取3~3.5岁、3.5~4岁、4~4.5岁3个年龄群组幼儿为被试,采用群组序列的追踪设计,进行为期1年半的追踪测量,结合潜变量增长曲线模型和多层线性模型处理数据,探讨幼儿在3~6岁间人格的发展特点。结果:(1)幼儿的智能特征、认真自控、外倾性、亲社会性、情绪稳定性5个人格维度在3~4岁发展最快,4~5岁持续增长但发展速度放缓,到5~6岁时趋于平稳;(2)女孩的认真自控和亲社会性在3岁时显著高于男孩,但在3~6岁间的增长率不存在差异,即女孩的认真自控和亲社会性在幼儿阶段发展水平始终高于男孩。结论:从家庭进入幼儿园的环境变迁促使了幼儿人格的进一步发展,5岁左右幼儿人格开始初步形成;女孩的认真自控和亲社会性水平在幼儿阶段始终高于男孩。     

老子之道及其创生因子探究

"道"是老子哲学体系中的核心,老子不仅提出虚空的道是宇宙的本体,是无法用语言来描述的,而且说明道是混成之物,即道是有精妙的内部结构属性的,并从不同的侧面说明了认识"道"是混成之物的路径。道是由无限创生因子混融而成的系统,宇宙在创生及万物演化的过程中,道或无限的创生因子始终起着根本性的作用,即宇宙间的一切事物现象都是道所为。道是由创生因子混融而成的思想观点,可为现代宇宙论的发展提供新的思维维度,为科学探索真空世界的奥秘提供新的研究途径,推进现代宇宙学的进步。     

表象加工水平对错误记忆的影响

从表象加工水平角度考察引发错误记忆的因素。结果发现,深的表象加工水平能够抑制诱饵词产生较大的激活,减少错误记忆的发生。随着表象加工水平的加深,有意表象的错误记忆效应显著低于无意表象,而正确记忆效应则显著高于无意表象,表明表象加工水平对错误记忆具有重要影响。根据研究结果提出表象激活混淆假设,认为人们虽然可以用表象作为信息表征的方式,却无法直接获取与之联系的激活路径。当人们推测表象激活的来源时,容易混淆表象激活的来源,产生错误记忆。     

Customer's perceived value of waiting time for service events

The authors address the effects of money gain and loss on individually perceived value as predicted by prospect theory in a time gain‐and‐loss context. Three experiments were conducted. Experiment 1 results support the prospect theory concept of value function. According to Experiment 2 results, the amount of money involved exerted different impacts on individual perceptions—specifically, study participants preferred gaining $1 on one occasion to gaining 50 cents over two occasions and preferred losing $1 one time to losing 50 cents twice. Further, the combined results indicate that the study participants held different perceptions of the value of “short time” versus “little money”—that is, they preferred saving an extra 2 minutes on one occasion to saving 1 minute on two occasions and preferred waiting an extra 1 minute two times to waiting an extra 2 minutes one time. Copyright © 2014 John Wiley & Sons, Ltd.     

Cognitive decline in old age: separating retest effects from the effects of growing older

Repeated administration of cognitive tests improves test performance, making it difficult for researchers to gauge the true extent of age-related cognitive decline. The authors examined this issue using data from the Rush Religious Orders Study and linear mixed-effects models. At annual intervals for up to 8 years, more than 800 older Catholic clergy members completed the same set of 19 cognitive tests from which previously established composite measures of cognitive domains were derived. Retest effects on some measures were substantial and continued to accumulate even after 8 annual test readministrations, but effects on other measures were minimal. Across cognitive measures, retest effects were not related to age, sex, or education. Individual differences in retest effects were substantial but not consistent across cognitive measures. The results suggest that retest-based improvement in cognitive test performance can be substantial and persistent.