Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice

It is established that stress impairs spatial learning and memory via the hypothalamus-pituitary-adrenal axis response. Dopamine D1 receptors were also shown to be responsible for a stress-induced deficit of working memory. However, whether stress affects the subsequent emotional learning and memory is not elucidated yet. Here, we employed the well-established one-trial step-through task to study the effect of an acute psychological stress (induced by tail hanging for 5, 10, or 20?min) on emotional learning and memory, and the possible mechanisms as well. We demonstrated that tail hanging induced an obvious stress response. Either an acute tail-hanging stress or a single dose of intraperitoneally injected dopamine D1 receptor antagonist (SCH23390) significantly decreased the step-through latency in the one-trial step-through task. However, SCH23390 prevented the acute tail-hanging stress-induced decrease in the step-through latency. In addition, the effects of tail-hanging stress and/or SCH23390 on the changes in step-through latency were not through non-memory factors such as nociceptive perception and motor function. Our data indicate that the hyperactivation of dopamine D1 receptors mediated the stress-induced deficit of emotional learning and memory. This study may have clinical significance given that psychological stress is considered to play a role in susceptibility to some mental diseases such as depression and post-traumatic stress disorder.     

Eye movements of second language learners when reading spaced and unspaced Chinese text

The effect of spacing in relation to word segmentation was examined for four groups of non-native Chinese speakers (American, Korean, Japanese, and Thai) who were learning Chinese as second language. Chinese sentences with four types of spacing information were used: unspaced text, word-spaced text, character-spaced text, and nonword-spaced text. Also, participants' native languages were different in terms of their basic characteristics: English and Korean are spaced, whereas the other two are unspaced; Japanese is character based whereas the other three are alphabetic. Thus, we assessed whether any spacing effects were modulated by native language characteristics. Eye movement measures showed least disruption to reading for word-spaced text and longer reading times for unspaced than character-spaced text, with nonword-spaced text yielding the most disruption. These effects were uninfluenced by native language (though reading times differed between groups as a result of Chinese reading experience). Demarcation of word boundaries through spacing reduces non-native readers' uncertainty about the characters that constitute a word, thereby speeding lexical identification, and in turn, reading. More generally, the results indicate that words have psychological reality for those who are learning to read Chinese as a second language, and that segmentation of text into words is more beneficial to successful comprehension than is separating individual Chinese characters with spaces.     

The impact of development of population-based study in the biomedical field on laws and regulations: a cross-strait experience on biobank development

Together with the completion of the Human Genome Project, biomedical research has marched into the "Post-Genomic Era." In order to take advantage of this extracted gene related information extensively and precisely so as to realize man's biological phenomena as well as the mechanism of pathogenesis, consequentially, a large scale sample collection of different geological areas and/or ethnic groups becomes necessary for the future population based genetic research of a country and, in turn, the construction of population-based genetic database (Biobank). In recent years, both mainland China and Taiwan have not only made great progress in information and computation technologies, but have also gradually taken a close look into the quality of medicine delivery. Thus, it becomes unavoidable for both sides to create each one's population-based genetic databases (Biobank). Theoretically speaking, the Biobank development shall benefit the study on the correlation between genes and disease and also the solution for disease treatment as well. At the same time, medical diagnostic technology has also been significantly improved. It is believable that the population-based genetic database might be utilized to promote medical quality and to reduce the cost of public health delivery. Further; in the near future, it might become the "raw materials "for medical research application. However when taking promotion of public welfare as the premises for a Biobank development, the severe and multi challenge occurred against the traditional legal rules in terms of the privacy protection, public trust development, the compliance of informed consent principle, the implementation of benefit-sharing doctrine and the possible discrimination concern about the population/participants selection and some other ELSI issues. In this paper, the major legal issues encountered by the Biobank development will first be reviewed accompanied by the background information concerning the Biobank development scenario crossing the Taiwan Strait. Also, mainly following the realm of comparative policy or legal approaches, the paper learning from the fruits of this comparative study, tries to propose some recommendations for future legislative consideration by both mainland China and Taiwan. It's been this author's wish that, when establishing a large scale population based Biobank, the promotion of public trust shall be placed as the primary goal together with the emphasis on supporting publicity and transparency on the administrative practices, so as to encourage the public participation in observing the principle of altruism and, in turn, benefit the future biomedicine development.     

Validating the coping scale for Chinese athletes using multidimensional Rasch analysis

Objective

The Coping Scale for Chinese Athletes (CSCA) was developed and validated using classic testing theory in 2004 (Chung, Si, Lee, & Liu, 2004). This study aimed to validate CSCA using multidimensional Rasch analysis with the ConQuest software programme.

Method

The sample in this study comprised 367 athletes from mainland China. A Multidimensional Rating Scale model was applied to investigate the validity of the four-dimension scale. Standard fit statistics (Infit and Outfit MNSQ) and Differential item functioning (DIF) were computed to examine the model-data fit. Test reliability and category functioning were also checked.

Results

The item difficulty and the athletes’ trait level of coping were calibrated along the same latent trait scale. Three items were removed from the scale due to misfit with the Rasch model. No DIF across gender was found for the remaining 21 items. Test reliabilities for the four subscales ranged from 0.66 to 0.76. The results also indicated that the original 5-category rating scale structure did not function well.

Conclusion

The multidimensional Rasch analysis supported that the 21-item CSCA measures four latent traits of coping of Chinese athletes as expected. The results also demonstrated advantages of multidimensional Rasch analysis over unidimensional Rasch analysis as well as traditional approach in examining the quality of multidimensional scale in sport settings.     

Customer reactions to encountering consecutive service failures

According to previous studies, many consumers in Taiwan have experienced consecutive service failures. Despite these failures, many consumers still remain loyal to a service provider for a variety of reasons, such as money deposits, contractual agreements, associated costs, time constrains, and health concerns. We attempt to investigate the emotional reactions and expectations of consumers after they have experienced two consecutive service failures. Our findings reveal that for high‐involvement services, although customers display strong negative emotional reactions after each service failure, the reaction to the second service failure is less intensive than that to the first one. Furthermore, our findings show that as long as the products or services remain in use, customers tend to retain high levels of expectation in regard to the service provider. Copyright © 2012 John Wiley & Sons, Ltd.     

Immigrant Youth and Employment: Lessons Learned from the Analysis of LSIC and 82 Lived Stories

Finding a job has become a critical challenge to many youth. Immigrant youth, who have been a key part of the global migrants, are particularly vulnerable when entering the job market of the host country due to various structural barriers. However, in both public policy discourse and research, their labour market experience tends to be overlooked. In this paper, we report the employment experience of recently arrived immigrant youth based on an analysis of the LSIC and findings of in-depth interviews of 82 immigrant youth in four cities in Canada. Our results reveal that recently arrived immigrant youth tend to work in lower-skilled employment, experience significant delays in finding employment, have difficulties with foreign credential recognition, and have fewer means to access to job markets.     

Distinct processing for pictures of animals and objects: evidence from eye movements

Many studies have suggested that emotional stimuli orient and engage attention. There is also evidence that animate stimuli, such as those from humans and animals, cause attentional bias. However, categorical and emotional factors are usually mixed, and it is unclear to what extent human context influences attentional allocation. To address this issue, we tracked participants' eye movements while they viewed pictures with animals and inanimate images (i.e., category) as focal objects. These pictures had either negative or neutral emotional valence, and either human body parts or nonhuman parts were near the focal objects (i.e., context). The picture's valence, arousal, position, size, and most of the low-level visual features were matched across categories. The results showed that nonhuman animals were more likely to be attended to and to be attended to for longer times than inanimate objects. The same pattern held for the human contexts (vs. nonhuman contexts). The effects of emotional valence, category, and context interacted. Specifically, in images with a negative valence, focal animals and objects with human context had comparable numbers of gaze fixations and gaze duration. These results highlighted the attentional bias to animate parts of a picture and clarified that the effects of category, valence, and picture context interacted to influence attentional allocation.     

Spatial orienting in the visual field: a unified perceptual space?

Visual attention can be oriented toward a spatial location in the visual field exogenously by an abrupt onset of a peripheral cue. In a series of behavioral studies on exogenous orienting of attention with a double-cue paradigm, we demonstrated a functional subdivision of perceptual space in the visual field. Specifically, inhibition of return (IOR) is much stronger at periphery relative to perifoveal visual field up to approximately 15° eccentricity, suggesting two dissociable functional areas in the visual field. To further investigate the generality of this functional subdivision of the visual field, we measured IOR effects with another single-cue paradigm and applied a very short cue-target interval that was typically anticipated not to observe any inhibitory effect at all. Consistent with this expectation, no IOR effects at the eccentricities up to 15° were observed. However, significant IOR effects beyond 15° eccentricities were consistently demonstrated. These results not only revealed an early onset of IOR for more peripheral stimuli, but also confirmed that the perceptual space in the visual field is not homogeneous but underlies a functional subdivision with a border of ca. 15° eccentricity.     

fMRI correlates of inhibition of return in perifoveal and peripheral visual field

When a target appears in the same peripheral location as a previous cue, responding is typically delayed if the cue-target interval is relatively long. This phenomenon is termed inhibition of return (IOR) and has been suggested to reflect an attentional bias in favour of novel visual space. It has been demonstrated recently that IOR is much stronger in the far periphery than in the perifoveal visual field. The present study further investigated the neural mechanisms underlying this eccentricity effect of IOR with an event-related fMRI technique. The results demonstrated a stronger activation in visual cortex for perifoveal processing and a broader activation in multiple brain areas for peripheral processing. When IOR effects were compared between these two areas, a stronger activation of the fronto-parietal network was evidenced for perifoveal versus peripheral IOR, while the prefrontal cortex was more strongly involved in the peripheral IOR versus perifoveal IOR. These results suggest that different neural mechanisms are mediating the dissociable inhibitory functions between the perifoveal and peripheral visual field.     

Psychometric properties of Attitudes Towards Lesbians and Gay Men Scale with Chinese university students

The 10-item Attitudes Towards Lesbian and Gay Men Scale was translated into traditional Chinese, with slight modification in item wordings (by replacing the words such as "lesbians" with "female homosexuals" and "gay men" with "male homosexuals"). Data were collected with a convenient sample of 462 Chinese undergraduate students in social work training programmes from three Hong Kong universities. Analysis of the data showed responses to the scale and its two subscales were internally consistent and a one-factor structure was found on the total scale and separately on each of its two subscales. Differences by religious belief and sex were observed using the total scale scores, as in previous studies using this scale. Researchers could consider using this scale with Hong Kong Chinese and in subsequent cross-cultural studies involving a wider range of Chinese respondents.