人工智能辅助的自闭症早期患者的筛查与诊断

自闭症谱系障碍(AutisticSpectrumDisorders,ASD)的症状早在婴幼儿期就会显现,越早发现,越早干预,治疗效果越好。传统自闭症早期筛查与诊断在评估方法、流程上存在局限,无法满足大规模筛查和诊断需求。随着人工智能技术的快速发展,使用智能化方法进行自闭症早期大规模无感筛查与诊断逐渐成为可能。近10年间,国内外对自闭症智能化识别方法的探索在经典任务行为、面部表情和情绪、眼动、脑影像、运动控制和运动模式、多模态6个领域积累了丰富的研究成果。未来研究应围绕构建国内自闭症早期智能医学筛查与诊断体系,开发针对婴幼儿患者的筛查工具,构建融合多模态数据的自闭症婴幼儿智能化识别模型,建立结合脑影像技术的自闭症精细化诊断方法等方面来开展。     

DGAVP易化记忆巩固过程与脑内蛋白质合成关系的探讨

本实验研究了脱甘氨酰胺精氨酸加压素(DGAVP)易化记忆巩固过程的作用,证明DGAVP能够防止蛋白质合成抑制剂茴香霉素(ANI)对记忆的破坏作用,并从突触体水平上探讨了DGAVP的作用与蛋白质合成的关系。 实验结果表明:(1)在复杂迷宫趋食反应中,DGAVP能够增强小鼠对觅食路径的记忆。(2)ANI破坏小鼠的记忆,而预先给予DGAVP则能防止ANI的破坏作用;在一次性被动回避反应中ANI和DGAVP的作用与迷宫实验的结果一致。(3)ANI抑制究触体对蛋白质合成前体亮氨酸的摄取,作用非常显著。DGAVP能够改善ANI的抑制效应,体外和体内的实验结果完全一致。实验结果提示DGAVP的作用机制与蛋白质合成有一定关系。     

关于汉字识别加工单位的研究

以眼动为指标的研究发现,汉字识别是以笔画为单位进行加工的。而词识别单位化模型则认为对熟悉词的识别与组成词的字母加工无关。本研究利用汉字具有笔画多少不同及组成部件不等的差别,以独体字或少笔画字为对照,通过三个实验探讨了高频和低频汉字识别的加工单位问题。实验结果表明,高频字笔画数和部件数分别对字识别产生显著影响,低频字似乎只有当笔画数和部件数两种成分都具有一定差异时才表现出识别速度的显著差别。此结果不支持前述的两种模型。提出汉字识别是由多种成分综合作用的结果似更合理。     

罪犯改造成效评估量表的建构

本研究运用因素分析法,尝试建构我国监狱中罪犯改造成效评估量走。该量表分Ａ版（干警评定量表）与Ｂ版（服刑人员他评量表）。结果表明,该量表具有较高的信度、效度,所得的改造成效评估三因素结构合理,内容清晰     

中文双音节词视觉识别与短时记忆保持量

两个实验探讨了汉语双音节词的使用度、笔画复杂性与发音长短对短时记忆保持量的影响。结果表明发音长度显著不同的词在记忆保持量上无显著差别;使用度和笔画复杂性对短时记忆保持量有显著影响;笔画复杂性不同的词识别时间与其记忆保持量有显著负相关。最后讨论了笔画复杂性的短时记忆量与词的识别阶段的可能关系。     

Transitions in sleep problems from late adolescence to young adulthood: A longitudinal analysis of the effects of peer victimization

Adolescence is a developmental period with high vulnerability to sleep problems. However, research identifying distinct patterns and underlying determinants of sleep problems is scarce. This study investigated discrete subgroups of, changes in, and stability of sleep problems. We also examined whether peer victimization influenced sleep problem subgroups and transitions in patterns of sleep problems from late adolescence to young adulthood. Sex differences in the effects of peer victimization were also explored. In total, 1,455 male and 1,399 female adolescents from northern Taiwan participated in this longitudinal study. Latent transition analysis was used to examine changes in patterns of sleep problems and the effects of peer victimization on these changes. We identified three subgroups of sleep problems in males and two in females, and found that there was a certain level of instability in patterns of sleep problems during the study period. For both sexes, those with greater increases in peer victimization over time were more likely to change from being a good sleeper to a poor sleeper. The effects of peer victimization on baseline status of sleep problems, however, was only significant for males, with those exposed to higher levels of peer victimization more likely to be poor sleepers at baseline. Our findings reveal an important role of peer victimization in predicting transitions in patterns of sleep problems. Intervention programs aimed at decreasing peer victimization may help reduce the development and escalation of sleep problems among adolescents, especially in males.

     

学习困难青少年认知控制特点研究

本研究基于双重认知控制理论,通过比较学困组和对照组在持续性操作任务上的表现来探究学习困难青少年的认知控制特点。结果发现：（1）在反应性控制的指标上,学困组和对照组的反应时和正确率不存在显著差异,但学困组对探测刺激的辨别力指数更低,显示学困组的反应性控制能力存在一定不足;（2）在主动性控制的指标上,学困组的反应时更长、正确率更低,且对线索刺激的辨别力指数更低,显示学困组在对线索刺激保持的各项指标上都比对照组更差,说明学困组在主动性控制上的缺陷更为明显。     

注意分心对定义一体化编码的影响

通过考察编码阶段注意分心对定义一体化条件下联结记忆成绩的影响,探究定义一体化编码对注意资源的依赖程度。使用注意分心范式,在记忆编码过程操作无分心、奇偶分心和大小分心条件,比较不同注意条件下的联结记忆成绩。结果发现:与无分心条件相比,定义一体化下的联结记忆成绩在两种分心条件下没有显著变化,而造句下的联结记忆成绩在两种分心条件下显著降低。当前发现表明了定义一体化编码较少依赖于注意资源,这深化了对定义一体化编码机制的认识。     

Evaluating the Effectiveness of a Group CBT for Parents of ADHD Children

Improvements in parenting skills do not necessarily lead to improvements in child and parent outcomes for children with attention deficit and hyperactivity disorder (ADHD). Cognitive factors such as parental cognitions and parenting self-efficacy may influence such outcomes. Clinical research on the effects of cognitive-behaviour therapy (CBT) on parental cognitions, parenting self-efficacy and mental health in Chinese parents of children with ADHD is lacking. This quasi-experimental study intended to assess the effects of a culturally attuned group CBT treatment on the mental health and quality of life of Chinese parents aged 26–58 years, with children with ADHD in Hong Kong. Participants in the experimental group received group CBT and standard treatment and their counterparts in the control group received standard treatment. Primary outcome variables of mental health and quality of life and process variables including parenting stress, parenting efficacy and dysfunctional attitudes were measured at baseline, post-treatment and 3-month follow-up. Data were analysed using 2?×?3 ANCOVAs, Cohen’s d statistics and multiple mediation analyses. Group by time interactions were found for most outcome variables. Effect size statistics indicated that group CBT had small to moderate effects on most outcome variables at post-treatment and follow-up assessments. The effect of CBT on mental health was mediated by the reduction in parenting stress and the effect of CBT on quality of life was mediated by the reductions in parenting stress and dysfunctional attitudes. Given its potential benefit, it is worth considering incorporating this group CBT programme into interventions for Chinese parents with ADHD children.