Development and Pilot Testing of a Decision Aid for Genomic Research Participants Notified of Clinically Actionable Research Findings for Cancer Risk

Germline genomic testing is increasingly used in research to identify genetic causes of disease, including cancer. However, there is evidence that individuals who are notified of clinically actionable research findings have difficulty making informed decisions regarding uptake of genetic counseling for these findings. This study aimed to produce and pilot test a decision aid to assist participants in genomic research studies who are notified of clinically actionable research findings to make informed choices regarding uptake of genetic counseling. Development was guided by published literature, the International Patient Decision Aid Standards, and the expertise of a steering committee of clinicians, researchers, and consumers. Decision aid acceptability was assessed by self-report questionnaire. All 19 participants stated that the decision aid was easy to read, clearly presented, increased their understanding of the implications of taking up research findings, and would be helpful in decision-making. While low to moderate levels of distress/worry were reported after reading the booklet, a majority of participants also reported feeling reassured. All participants would recommend the booklet to others considering uptake of clinically actionable research findings. Results indicate the decision aid is acceptable to the target audience, with potential as a useful decision support tool for genomic research participants.     

干细胞研究中的多向立体思维方法

干细胞研究取得了里程碑式的进展,在临床疾病的预防和治疗中具有广阔的应用前景,这些研究成果凝聚了各国研究人员的集体智慧,多向立体思维方法得到了充分体现。     

论保护基因隐私需要引入权利形式

基因技术的发展将基因隐私保护问题摆在人类面前,“采用怎样的方式才能有效保护基因隐私”是一个亟待解决的疑问。从分析侵犯基因隐私所带来的社会危害出发,对“权利形式是否适用于保护基因隐私”这一问题进行分析,并得出肯定性结论。     

新型冠状病毒肺炎定点医院医护人员心理状况调查分析

为了解定点收治新型冠状病毒肺炎患者的医院中医护人员心理状况,从而针对性地进行心理护理,采用便利抽样法,应用《医护人员心理健康调查表》对3所定点收治新型冠状病毒肺炎患者的医院中1 266名医护人员进行问卷调查。结果显示,定点医院医护人员中,27.5%存在抑郁,26.3%存在焦虑,26.0%存在孤独。女性、已婚、传染科、发热门诊、监护室相比男性、未婚、普通门诊更容易抑郁;传染科、监护室相比普通门诊更容易焦虑。因此,医院应加强对这类群体的心理疏导和人文关怀,以减轻心理压力,提高工作效率。     

糖尿病防治的策略转变——从关注糖化血红蛋白到着眼心血管事件

通过对2型糖尿病心血管终点事件的观察,更多的临床证据提示,糖尿病的治疗目标应该以减少心血管事件为主。糖尿病防治从策略上发生了两个转变,即以血糖为中心转向以防治心血管事件为中心的多危险因素综合防治策略;以糖化血红蛋白检测作为血糖评价的金标准转向以血糖量、质、时程控制的全面评价策略。     

Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months

Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy that highlights the 9‐ to 10‐month period as a time interval of maximal individual differences. We then demonstrate that fractional anisotropy in the right uncinate fasciculus, a white matter fiber bundle connecting the amygdala to the ventral‐medial prefrontal cortex and anterior temporal pole, measured in 6‐month‐olds predicts individual differences in responding to joint attention at 9 months of age. The white matter microstructure of the right uncinate was not related to receptive language ability at 9 months. These findings suggest that the development of core nonverbal social communication skills in infancy is largely supported by preceding developments within right lateralized frontotemporal brain systems.     

糖尿病防治的策略转变——从关注糖化血红蛋白到着眼心血管事件

通过对2型糖尿痛心血管终点事件的观察,更多的临床证据提示,糖尿病的治疗目标应该以减少心血管事件为主.糖尿病防治从策略上发生了两个转变,即以血糖为中心转向以防治心血管事件为中心的多危险因素综合防治策略,以糖化血红蛋白检测作为血糖评价的金标准转向以血糖量、质、时程控制的全面评价策略.     

新型农村合作医疗制度进一步发展的瓶颈分析

提出制约新农合制度发展的瓶颈有：筹资方式及筹资成本问题、筹资水平、补偿内容的设计问题、过多照搬了城镇职工基本医疗保险的资金管理方式、管理能力与管理手段、位于卫生局内的合管办、无法实现“解决因病致贫、因病返贫”的政策目标。     

Social media addiction and psychological adjustment: religiosity and spirituality in the age of social media

Previous research indicates a significant association between social media use and psychological adjustment. The present study investigated whether religiosity/spirituality mediates the relationship between social media intrusion and psychological adjustment. Participants completed a demographic questionnaire, Religious Commitment Inventory-10, Spirituality Index of Well-Being, the DASS-21 Scales, and the Facebook Intrusion Questionnaire, which was altered slightly to include all types of social media. Results revealed that social media intrusion was significantly positively associated with depression, anxiety, and stress, and negatively correlated with spiritual well-being and the self-efficacy component of spiritual well-being. Furthermore, the self-efficacy dimension of spiritual well-being partially mediated the association between social media intrusion and psychological stress. From these results, it may be inferred that higher social media intrusion may have the ability to decrease specific aspects of spirituality, which may, in turn, negatively impact psychological adjustment. Limitations and future directions are discussed.     

Drugs,Sex, and Condoms: Identification and Interpretation of Race‐Specific Cultural Messages Influencing Black Gay and Bisexual Young Men Living with HIV

Black gay and bisexual young men carry a disproportionate burden of HIV in the United States. This study explored Black gay and bisexual young men living with HIV's identification and interpretation of race‐specific cultural messages regarding substance use, sexual activity, and condom use. A total of 36 Black gay and bisexual young men living with HIV (ages 16–24, mean = 20.6 years) from four geographically diverse regions of the United States participated in qualitative in‐depth interviews. Results from this study elucidate the ways in which these young men interpret various forms of race‐specific cultural messages and experiences regarding substance use, sexual activity, and condom use. Participants discussed cultural messages and experiences promoting and discouraging condoms and substance use. Regarding sexual activity, only messages and experiences promoting sex were reported. Across all three categories, messages and experiences promoting risk were predominant. Data further revealed that socially transmitted cultural messages received by young men emanated from multiple sources, such as family, peers, sexual partners, community/neighborhood, and the broader society. Race‐specific cultural messages and experiences should be addressed in interventions for this population, and programs should assist young men in developing a critical consciousness regarding these messages and experiences in order to promote health and well‐being.