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101.
肺癌的流行始于20世纪,目前已成为全球最常见的恶性肿瘤.戒烟是已知最有效的肺癌预防策略.一百年来,全球戒烟运动的发展是曲折前行的.历史经验揭示实现肺癌的预防与控制需要一个综合、有效的戒烟运动体系,应当是多层面、多角度的.体系的构建过程将生动地见证"大医学发展观"对人类重大疾病有效控制的深刻影响. 相似文献
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Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment 总被引:1,自引:0,他引:1 下载免费PDF全文
Shum FW Wu LJ Zhao MG Toyoda H Xu H Ren M Pinaud R Ko SW Lee YS Kaang BK Zhuo M 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(4):304-312
Exposure to an enriched environment (EE) has been shown to induce cortical plasticity. Considerable amount of research is focused on the effects of EE in the hippocampus; however, effects of EE on other brain regions and the mechanisms involved are not well known. To investigate this, we induced cortical plasticity by placing mice in an EE for one month and measured the effects of EE in the anterior cingulate cortex (ACC). Here, we show that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulate long-term potentiation (LTP) and decreased cingulate long-term depression (LTD). The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged. Furthermore, behavioral experiments show that these mice exposed to EE demonstrate enhanced responses to acute and long-term inflammation. Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation. 相似文献
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We describe our ongoing program of research related to the assessment of contextualized personality, focusing on social roles and cultural cues as contextual factors. First, we present our research employing the traditional assessment approach, wherein participants are asked to rate explicitly their personality across several different roles. We argue that this hypothetical approach is potentially susceptible to the influence of stereotypes, social desirability, and demand characteristics. We therefore describe the development of three novel and subtle assessment procedures that are based on obtaining online self-representations that are activated while occupying a specific context. Finally, the strengths and limitations of all four approaches, as well as directions for future research in the study of contextualized personality, are discussed. 相似文献
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To assess the learning of word form and meaning in an unfamiliar writing system, we carried out primed-naming experiments with learners of Chinese at the end of their first and second terms in a Chinese class at an American university. The subjects were required to name a target Chinese character after a prime character had been presented for 500 msec. There were three priming conditions defined by the relation between the prime and the target: orthographically similar, homophonic, and semantically related. At the end of the first term, there was a significant facilitation for naming speed in the orthographic condition, but not in the homophonic or semantic conditions. However, at the end of the second term, orthographical facilitation disappeared. Instead, naming speed was facilitated by semantically related primes. A threshold-style framework was proposed to illustrate the processing of Chinese orthography, phonology, and semantics by second-language learners. 相似文献
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本研究以487名幼儿为被试,探讨害羞与社会适应的关系,以及母亲教养方式在害羞与社会适应之间的调节作用。幼儿母亲完成儿童社会偏好量表和教养方式问卷,幼儿教师完成对幼儿社会适应的评价。结果表明:(1)害羞与不合群和同伴排斥显著正相关;(2)母亲教养方式在害羞与社会适应之间具有调节作用。具体来说,母亲温暖、说理和鼓励自主的教养方式可减弱害羞幼儿的消极适应,而体罚和指令型的教养方式会加剧害羞幼儿的消极适应。研究结果对于害羞幼儿的干预具有重要价值。 相似文献