关于血管内皮细胞生长因子基因治疗

血管内皮细胞生长因子具有强大的促血管新生的作用,基因治疗可以明显地促进缺血组织的血管新生,治疗作用明显。但如果局部表达浓度过高,则会形成血管瘤组织。同时这也为血管瘤的研究提供了很好的动物模型。     

加入WTO对我国医药卫生科学研究的影响及对策

中国加入WTO,不仅对我国经济和社会的发展带来机遇和挑战,而且对我们的医药卫生科学研究的发展,产生巨大的影响。这就需要我们采取积极的措施,变压力为动力,加速我国医药卫生科学研究和学科建设的发展。     

肿瘤细胞耐药的哲学内涵

化学疗法是目前治疗肿瘤的主要措施 ,而肿瘤细胞对化学药物往往容易产生耐受 ,并成为临床治疗肿瘤取得满意疗效的主要障碍之一。肿瘤细胞对一种使用过的抗肿瘤化疗药物产生耐药之后 ,同时对多种不同结构、不同作用机制的抗肿瘤药物也产生交叉耐药现象 ,称为肿瘤多药耐药性 (Ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ ,ＭＤＲ)。肿瘤耐药的形成既是细胞生物发展的一种自然规律 ,也是细胞生物行为的必然现象。其间包含了许多哲学的内涵。1　生物进化与肿瘤细胞耐药的形成进化的概念衍生于人们对生物起源的认识。拉马克、达尔文等人根据大量事实…     

Judging egocentric distance on the ground: occlusion and surface integration

On the basis of the finding that a common and homogeneous ground surface is vital for accurate egocentric distance judgments (Sinai et al, 1998 Nature 395 497-500), we propose a sequential-surface-integration-process (SSIP) hypothesis to elucidate how the visual system constructs a representation of the ground-surface in the intermediate distance range. According to the SSIP hypothesis, a near ground-surface representation is formed from near depth cues, and is utilized as an anchor to integrate the more distant surfaces by using texture-gradient information as the depth cue. The SSIP hypothesis provides an explanation for the finding that egocentric distance judgment is underestimated when a texture boundary exists on the ground surface that commonly supports the observer and target. We tested the prediction that the fidelity of the visually represented ground-surface reference frame depends on how the visual system selects the surface information for integration. Specifically, if information is selected along a direct route between the observer and target where the ground surface is disrupted by an occluding object, the ground surface will be inaccurately represented. In experiments 1-3 we used a perceptual task and two different visually directed tasks to show that this leads to egocentric distance underestimation. Judgment is accurate however, when the observer selects the continuous ground information bypassing the occluding object (indirect route), as found in experiments 4 and 5 with a visually directed task. Altogether, our findings provide support for the SSIP hypothesis and reveal, surprisingly, that the phenomenal visual space is not unique but depends on how optic information is selected.     

Private self-consciousness factors: relationships with need for cognition, locus of control, and obsessive thinking in Iran and the United States

The authors measured Internal State Awareness (ISA) and Self-Reflectiveness (SR) factors from the Private Self-Consciousness Scale in Iranian (N = 325) and U.S. (N = 401) university students. In both societies, positive correlations with Need for Cognition and Internal Control and negative correlations with external control and obsessive thinking confirmed ISA as an adaptive form of self-consciousness. In partial correlations in which the authors controlled for ISA, SR was associated cross-culturally with greater Obsessive Thinking. This outcome conformed with the authors' expectations that SR would have negative mental health implications, but other data revealed complexities in the SR association with adjustment. Differences between samples failed to yield any simple support for F. Fukuyama's (1992) suggestion that Iranians might be more "alienated" (pp. 236-237) in their psychological functioning. The present study most importantly offered cross-cultural evidence in favor of the claim that better measures of an introspective self-awareness need to be developed.     

非小细胞肺癌的综合诊治策略——NCCN肿瘤学临床实践指南(2006第二版)评析

肺癌目前位于世界肿瘤死亡原因的首位.肺癌的治疗应根据临床不同的分期,选择规范化的治疗方案.肺癌规范化综合治疗可使早期肺癌患者5年生存率达50%～70%左右.中晚期达到25%左右.美国NCCN肿瘤学临床实践指南在2006年发布了第二版非小细胞肺癌治疗方案,对于规范化治疗肺癌以及提高肺癌病人生存率和生存质量有着积极的意义.     

Schooling experience and academic performance of Taiwanese students: the importance of psychosocial effects,positive emotions,levels of best practice,and personal well-being

Social Psychology of Education - The present study considered global self-esteem and academic self-efficacy as two contrasting precursors and distinctive pathways that could account for...     

历代名人吟咏镇海寺

~~五台山学智,并有自利利他的行为,而感到欢喜,故名。徘徊:来回行走的意思。这句是说,佛教认为来去今过都是空的,菩萨到了初地时,虽然已得意忘言,发起了中道之智,但还在徘徊犹豫。[6]这句是说,不要因为隐士和神仙所居的沧洲、瀛洲离我们很远,就说和尚就修不成菩萨和佛。[7]宾王:亦或辅佐帝王的高官大臣。灵隐:即杭州市灵隐寺。这句是说,随从乾隆皇帝第五次去五台山的高官大臣,只会认识灵隐寺,吟咏灵隐寺,但他们在观海的话,思想还是潮起潮伏,静不下心来,没有入定,没有解脱。[8]这句是说,镇海寺正院旁边还有一个院落,名叫永乐院,里面盖着三间…