Phosphorylated nerve growth factor-induced clone B (NGFI-B) translocates from the nucleus to mitochondria of stressed rat cardiomyocytes and induces apoptosis

Stress induces cardiac dysfunction and cardiomyocyte injury, and while current data indicate that mitochondria play a key role in this process, the mechanisms remain unknown. In this study, we found that in rats, restraint stress induced nerve growth factor-induced clone B (NGFI-B) translocation from the nucleus to mitochondria in cardiomyocytes. This translocation promoted cytochrome c release from mitochondria to the cytoplasm, which ultimately resulted in cardiomyocyte apoptosis. We also found that stress induced oversecretion of glucocorticoids and activated the protein kinase A (PKA) pathway in cardiomyocytes. Enhanced PKA activity increased NGFI-B serine phosphorylation, which caused NGFI-B to translocate from the nucleus to mitochondria. Moreover, a PKA peptide inhibitor blocked NGFI-B serine phosphorylation and translocation. Our data demonstrate that stress affects cardiomyocytes by inducing NGFI-B mitochondrial translocation via serine phosphorylation, which in turn initiates mitochondrial-mediated apoptosis.     

青少年留守经历对网络成瘾的影响:病理性互联网使用的认知行为模型视角

基于病理性互联网使用的认知行为模型,本研究考察青少年留守经历对网络成瘾的影响,并检验非适应性认知的中介作用和粗暴养育的调节作用。以525名中学生为被试,采用非适应性认知问卷、粗暴养育问卷和网络成瘾问卷进行测试,结果发现:(1)有留守经历的个体非适应性认知和网络成瘾的程度更高,而且非适应性认知越强,网络成瘾程度越高;(2)留守经历通过非适应性认知的中介作用影响网络成瘾;(3)留守经历对非适应性认知的影响受到粗暴养育的调节。具体而言,经历较多粗暴养育的青少年,留守经历会增加非适应性认知;但是对于经历较少粗暴养育的青少年,留守经历不会对非适应性认知产生影响。本研究的结果表明,青少年留守经历会增强非适应性认知,进而增加网络成瘾的倾向。但是,如果青少年家庭中粗暴养育程度较低,青少年留守经历对非适应性认知的影响就会消失。     

儿童期虐待对大学生公正世界信念的影响:有调节的中介模型

为探讨儿童期虐待对公正世界信念的作用及心理机制,本研究采用问卷法对929名大学生进行了调查,并采用潜变量模型对数据进行了分析。结果发现:(1)儿童期虐待显著负向预测大学生公正世界信念;(2)控制感在儿童期虐待与公正世界信念之间起完全中介作用;(3)家庭社会经济地位调节了儿童期虐待与控制感的关系,高家庭社会经济地位放大了儿童期虐待与控制感间的负相关。研究结果表明,可以通过预防儿童虐待和增强控制感等干预措施来提升公正世界信念,并且需要对高社会经济地位家庭的儿童虐待加大关注。     

聋人句子阅读中的视觉功能补偿现象：副中央凹−中央凹效应的证据

聋人阅读过程中的视觉功能补偿现象是由于听觉信息的缺失,聋人的视觉功能会发生补偿性改变,表现为对副中央凹视野内文本信息的加工效率更高。本研究采用边界范式,测量聋人的副中央凹-中央凹重复效应,以探究聋人的副中央凹视觉功能补偿现象能否促进其中央凹的词汇识别过程。结果发现,聋人的副中央凹-中央凹重复效应出现在早期阅读指标凝视时间,而阅读能力匹配组只出现在晚期阅读指标总注视时间。因此,相比阅读能力匹配的健听读者,聋人的副中央凹-中央凹重复效应出现得更早,表现出副中央凹视觉功能补偿现象。     

打坐健身机制新探

打坐是一种席地端坐时将两腿交叉相压并调息入静的锻炼方式。打坐行为历史悠久,具有良好的健身作用,近年还发现对心脑血管疾病有一定治疗康复作用。但在中国由于打坐经常被认为属于宗教修炼而被普通大众忽视。本文将打坐与宗教分离开来,通过现代医学理论从调整呼吸、入静、远程缺血预适应保护等对神经系统、内脏功能（肺、消化系统、心血管系统及淋巴循环功能）的影响方面探讨了打坐的健身机制,为进一步研究并向大众推广这种安全有效的健身方法提供一管之见。特别是对心血管系统的保护作用值得进一步研究利用。     

群体购买情境下冲动性购买影响研究：解释水平视角

本研究基于解释水平理论视角,检验了消费者在群体购买情境中的冲动性购买行为.研究1采用2（解释水平：高vs.低）＆#215;2（自我建构：独立vs.互依）组间因子设计,用来检验解释水平是否调节自我建构类型对冲动性购买的影响;研究2采用2（解释水平：高vs.低）＆#215;2（认知模式：感知vs.模拟）组间因子设计,检验认知模式和解释水平对冲动性购买的联合影响.实验结果表明：群体购买情境下,消费者自我建构类别不同,冲动性购买意愿也不同,且受到解释水平的调节影响;群体购买情境下,消费者对他人认知模式的不同,对自身冲动性购买的影响也不同,解释水平在其中也起到了调节作用.     

中小学生欺负者归因特点的研究

本研究以归因理论为依据,采用自编的中小学生欺负者归因量表对3-9年级学生施测,以考察中小学生欺负者归因的基本特点。结果发现:(1)中小学生较多地从IUC上知觉欺负者的欺负行为,较少从ESU上知觉该行为;(2)在ISC、ISU、IUC、EUC、EUU这五个原因上存在性别差异;(3)除ESU外的七项原因的知觉上存在组别差异;(4)对八项原因的知觉上均存在显著性年级差异;(5)独生子女因素对欺负者归因不存在显著性影响。     

恢复性环境研究:理论、方法与进展

近十年来,"恢复性环境"成为环境心理学研究的热点。目前,从恢复结果的角度,注意恢复理论和心理进化理论认为,恢复性环境是指有助于人们更好地从心理疲劳以及和压力相伴随的消极情绪、生理反应中恢复过来的环境。对该环境的研究主要采用量表法和实验法,研究结果涉及恢复结果、影响恢复的因素、恢复和偏好的关系、恢复性环境的眼动特征以及临床应用。今后应该更侧重对恢复性环境理论和研究设计的进一步完善、量表的效度验证,并加强研究成果的具体应用。     

Altered topological patterns of large-scale brain functional networks during passive hyperthermia

In this study, we simulated environmental heat exposure to 18 participants, and obtained functional magnetic resonance image (fMRI) data during resting state. Brain functional networks were constructed over a wide range of sparsity threshold according to a prior atlas dividing the whole cerebrum into 90 regions. Results of graph theoretical approaches showed that although brain networks in both normal and hyperthermia conditions exhibited economical small-world property, significant alterations in both global and nodal network metrics were demonstrated during hyperthermia. Specifically, a lower clustering coefficient, maintained shortest path length, a lower small-worldness, a lower mean local efficiency were found, indicating a tendency shift to a randomized network. Additionally, significant alterations in nodal efficiency were found in bilateral gyrus rectus, bilateral parahippocampal gyrus, bilateral insula, right caudate nucleus, bilateral putamen, left temporal pole of middle temporal gyrus, right inferior temporal gyrus. In consideration of physiological system changes, we found that the alterations of normalized clustering coefficient, small-worldness, mean normalized local efficiency were significantly correlated with the rectal temperature alteration, but failed to obtain significant correlations with the weight loss. More importantly, behavioral attention network test (ANT) after MRI scanning showed that the ANT effects were altered and correlated with the alterations of some global metrics (normalized shortest path length and normalized global efficiency) and prefrontal nodal efficiency (right dorsolateral superior frontal gyrus, right middle frontal gyrus and left orbital inferior frontal gyrus), implying behavioral deficits in executive control effects and maintained alerting and orienting effects during passive hyperthermia. The present study provided the first evidence for human brain functional disorder during passive hyperthermia according to graph theoretical analysis using resting-state fMRI.     

工作团队领导心理资本对成员组织公民行为的影响机制：多层次模型

本研究采用问卷调查法, 以某国有企业在10个地市的66个工作团队369名企业员工为调查对象, 在控制被试的教育程度、工作经验及人口统计学变量之后, 运用多层线性模型技术分析团队领导心理资本与团队成员心理资本及其组织公民行为的关系。结果发现：(1)工作团队领导心理资本对团队成员组织公民行为存在积极影响, 团队成员心理资本是领导心理资本与团队成员组织公民行为之间跨层次的中介变量; (2)工作团队领导心理资本对团队成员心理资本与组织公民行为关系的调节效应不显著。