Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear

Extinction of conditioned fear is an important model both of inhibitory learning and of behavior therapy for human anxiety disorders. Like other forms of learning, extinction learning is long-lasting and depends on regulated gene expression. Epigenetic mechanisms make an important contribution to persistent changes in gene expression; therefore, in these studies, we have investigated whether epigenetic regulation of gene expression contributes to fear extinction. Since brain-derived neurotrophic factor (BDNF) is crucial for synaptic plasticity and for the maintenance of long-term memory, we examined histone modifications around two BDNF gene promoters after extinction of cued fear, as potential targets of learning-induced epigenetic regulation of gene expression. Valproic acid (VPA), used for some time as an anticonvulsant and a mood stabilizer, modulates the expression of BDNF, and is a histone deacetylase (HDAC) inhibitor. Here, we report that extinction of conditioned fear is accompanied by a significant increase in histone H4 acetylation around the BDNF P4 gene promoter and increases in BDNF exon I and IV mRNA expression in prefrontal cortex, that VPA enhances long-term memory for extinction because of its HDAC inhibitor effects, and that VPA potentiates the effect of weak extinction training on histone H4 acetylation around both the BDNF P1 and P4 gene promoters and on BDNF exon IV mRNA expression. These results suggest a relationship between histone H4 modification, epigenetic regulation of BDNF gene expression, and long-term memory for extinction of conditioned fear. In addition, they suggest that HDAC inhibitors may become a useful pharmacological adjunct to psychotherapy for human anxiety disorders.     

Internet-delivered assessment and manipulation of anxiety-linked attentional bias: Validation of a free-access attentional probe software package

It recently has been established within the laboratory that the attentional probe methodology not only can sensitively assess the threat attentional bias associated with anxiety vulnerability, but also can be configured to yield training tasks capable of modifying emotional vulnerability by manipulating such attentional selectivity. In order to appraise and exploit the potential practical applications of such procedures, it is desirable that clinical investigators without specialist equipment should become able to deliver such tasks within field settings. The present research program involved development of a fully customizable attentional probe software package, that delivers assessment and training versions of the probe task across the Internet. Two experimental studies served to validate the assessment and training efficacy of resulting probe task variants, completed remotely by GAD sufferers and nonclinical populations using their own computers. We advise fellow researchers how to freely download this software package for use within their own investigations.     

视觉工作记忆在视觉搜索中的作用

视觉工作记忆在视觉搜索中的作用远比偏向竞争模型所描述的要复杂,个体能根据当前任务要求灵活地利用工作记忆来引导注意选择。在系统回顾已有研究的基础上,从客体工作记忆、空间工作记忆和执行工作记忆3个方面探讨了视觉工作记忆在视觉搜索中的作用。根据近期的研究,文章在最后对视觉工作记忆在视觉搜索中的作用做了7点总结,并对已往研究中存在的若干问题给予了解释,指出未来应该从前瞻记忆和内隐记忆等角度对视觉搜索中所涉及的视觉记忆进行深入研究     

中国心理健康服务从业者的职业压力现状及影响因素

本研究目的是考察心理健康从业者的压力现状及其影响因素。769名来自全国20个省份的心理健康从业者填写了研究者自编的有93个多项选择题和填空题的问卷,其中2个从本问卷中抽取的5点量表具有可接受的心理测量学指标。主因素分析表明,心理健康从业者的职业压力可分为三类:专业能力不足、缺乏单位支持、工作负担过重。回归分析表明:影响职业压力的非专业因素有:年龄,性别,教育水平,全职或兼职,场所是否专用,以及每周咨询的小时数。在专业因素中,督导和培训能显著地缓解心理健康从业者的职业压力。治疗中的困难情况会显著地引发心理健康从业者的职业压力。     

高考历史试卷的多元概化理论研究

运用多元概化理论及其方法,本研究分析了上海市高考历史试卷(2006年),结果发现:(1)在试卷结构,各部分试题具有较好的测量信度,但在赋分比例存在问题;(2)在主观题评分,评阅者对分数影响微弱,说明分数能较为真实地反映不同考生之间的学科知识和能力差异。此外,研究还为将来提高高考命题和评阅质量提供合理化建议。     

对话：医学人人文中的普世关怀与公共理性

对话主张,我们不妨暂时放弃最高限度的理想化方式（终极关怀）,转而寻求宽容、宽泛前提下的公共理性,医学不仅是科学的,更是人文的。而要推动技术教育至上背景下生长的一代青年学子完成这样一次沉重的转向,有两门学科不可绕过,一门是科学史,另一门是科学哲学。     

双语(或多语)是否有利抵御老年痴呆症？

近50年来的语言神经科学研究确认了双(多)语经验的认知效应。就10年来双(多)语经验抵御老年痴呆症(特别是阿尔茨海默症, AD)的研究成果进行了深入探讨, 并基于认知储备(cognitive reserve)理论, 从功能和结构两方面探讨了双语(多语)经验抵御AD的神经机制。从外语的类型、熟悉程度、开始习得年龄, 以及研究方法等角度提出了要解决的问题, 旨在推动外语学习和教学, 并为老年化疾病和跨学科语言学研究提供新的思路。     

IRT与MIRT在测验垂直等值中的应用

测验垂直等值是指将测试同一心理特质的不同水平的测验转换到同一个分数量尺上的过程。IRT与MIRT是实现垂直等值的主要方法。IRT无需假设被试的能力分布, 参数估计不依赖于样本, 是构建垂直量表的有效方法, 但测验不满足单维假设时其应用受到限制。MIRT结合IRT和因素分析的特点对IRT进行了拓展, 可更有效估计多维测验的项目参数和被试能力参数, 在垂直等值中有重要应用。已有研究主要探讨IRT和MIRT在垂直等值应用中的适用性、标定方法和参数估计方法, 比较研究两种方法的特性。未来研究应纳入更多变量条件进行比较研究, 拓展方法的应用。     

孤独症谱系障碍患者对种族情境中本异族面孔的眼动模式

本研究采用眼动技术探讨孤独症谱系障碍(ASD)患者对背景中的本异族面孔的加工特点。研究采用2（组别）×2（面孔种族）×3（背景）的混合设计,让16名16-25岁的ASD患者和17名生理年龄匹配的正常人完成变化检测任务,并记录他们的眼动。结果显示：与正常人相比,ASD患者的面孔辨别力更低;他们的眼动呈现更多的面孔-背景眼跳和更多的上下半脸眼跳;两组被试的上下半脸眼跳的次数受到面孔种族以及面孔和背景是否一致的影响。结论：在行为指标上,正常人出现了本族效应,而ASD患者没有出现本族效应;在眼动上,ASD患者呈现与正常人相似的面孔注视时间,但比正常人呈现更多的眼跳。面孔的背景影响了面孔辨别力以及上下半脸眼跳轨迹。     

情绪调节自我效能感与主观幸福感：情绪调节方式的中介作用

本研究的目的在于探讨青少年情绪调节自我效能感与主观幸福感之间的关系及情绪调节方式在其中的中介作用。采用《情绪调节自我效能感量表》、《情绪调节方式量表》和《主观幸福感量表》对1128名中学生进行测查,结果表明：(1) 情绪调节自我效能感与情绪调节方式、生活满意度、积极情感、消极情感关系紧密;(2) 情绪调节自我效能感和情绪调节方式可显著预测主观幸福感;(3) 减弱调节在情绪调节自我效能感与主观幸福感间起部分中介作用。