孤独症儿童动作发展障碍的神经机制

动作发展障碍(Developmental motor disorders)是孤独症谱系障碍的常见特征。通过系统回顾孤独症儿童动作发展障碍的神经科学研究, 发现γ-氨基丁酸和5-羟色胺浓度的改变及γ-氨基丁酸相关蛋白和Shank蛋白的表达异常不仅会损害中枢神经系统的发育, 而且还能导致突触兴奋性与抑制性失衡, 进而改变孤独症儿童小脑和大脑皮层运动区的功能连接。孤独症儿童小脑、基底神经节和胼胝体结构的改变对全脑的连通性产生了负面影响。神经生化机制和脑结构的异常共同导致了脑功能的异常, 最终造成孤独症儿童的动作发展障碍。此外, 动作发展障碍与孤独症核心症状共同的神经基础主要包括镜像神经元系统紊乱, 丘脑、基底神经节和小脑异常以及SLC7A5和PTEN 基因突变。未来研究需要关注与运动密切相关的其他神经递质, 如乙酰胆碱和多巴胺; 探索动作发展障碍神经网络的动态机制及其形成; 剖析该障碍的神经机制和自闭症核心症状神经机制的相互作用。     

自恋与行为抑制/激活系统的关系：元分析

运用元分析方法探讨自恋与行为抑制/激活系统的关系。经过文献检索和筛选, 纳入原始文献19篇, 包含25个独立样本, 共7702名被试。根据同质性检验结果, 选用随机效应模型。结果发现, 自恋与行为抑制系统存在中度负相关(r = -0.27, 95% CI为[-0.34, -0.21]), 自恋测量工具在两者间起显著的调节作用; 自恋与行为激活系统存在高度正相关(r = 0.46, 95% CI为[0.40, 0.52]), 被试类型在两者间起显著的调节作用。自恋与行为抑制/激活系统的密切关系支持了自恋的主体性理论和人格强化敏感性理论。     

Does Religious Activity Distinguish the Mortality Experiences of Older Taiwanese? An Analysis Using Eighteen Years of Follow-Up Data

This paper extends investigation of religiosity and longevity to Taiwan using a 1989 survey: N = 3849, aged 60+, with 18 years of follow-up. Religious activity is measured as worship and performance of rituals. A Gompertz regression, adjusted and non-adjusted for covariates and mediating factors, shows the hazard of dying is lower for the religiously active versus the non-active. Transformed into life table functions, a 60-year-old religiously active Taiwanese female lives more than 1 year longer than her non-religious counterpart, ceteris paribus. Mainland Chinese migrants are examined carefully because of unique religious and health characteristics. They live longer, but the religiosity gap is similar.

     

Effect of Acute Psychological Stress on Motion-in-Depth Perception: An Event-Related Potential Study

The present study explored the intrinsic event-related potential (ERP) features of the effects of acute psychological stress on the processing of motion-in-depth perception using a dual-task paradigm. After a mental arithmetic task was used to induce acute psychological stress, a collision task was used to evaluate motion-in-depth perception. The error value and average amplitude of late slow waves (SW) were significantly larger for the earlier colliding spheres’ than for the later colliding spheres. The P1 peak latency in the left occipital region was significantly shorter than that of the right occipital region in the motion-in-depth perception task. Compared to the control condition, the estimated value of residual time-to-collision and error value were significantly reduced, and the N1 peak amplitude and the SW averaged amplitude were significantly increased in the stress condition. Longer motion-in-depth time improved discrimination accuracy and decreased the investment of cognitive resources. Acute psychological stress increased behavioral performance and enhanced attention resources on the motion-in-depth perception task together with greater investment of cognitive resources.     

Wall,Gate and Self-Other Dynamics: A Confucian Ethics of Separation and Interconnection

This paper starts with the social and moral implications of wall in history and in the contemporary world, to usher in the early Confucian discourse on wall and gate. The Confucian discourse implies that walls—either actual, virtual or symbolic—are there to defend and/or to separate, while gates enable the managed access to and opening-up the self-imposed insularity or moderate the self-centred exclusiveness that walls imply. By way of reinterpretation and reconstruction, we will extract from a variety of Confucian discussions the ethical awareness that however strongly built, walls must be associated with gates, and that the wall and the gate are therefore locked in mutuality to make possible the reality of interconnectedness between the inside and the outside and between the self and the other. It will be argued that by using ethical virtues as tools to moderate separation and exclusiveness, Confucian discourses highlight the dynamics of the self-other relationship, and establishes an ethics that may well be still applicable to contemporary situations and can be drawn upon to help dissolve the tension between the values of populist self-centrism and those of globalist interconnectedness.     

Flexible parafoveal encoding of character order supports word predictability effects in Chinese reading: Evidence from eye movements

Several eye-movement studies have revealed flexibility in the parafoveal processing of character-order information in Chinese reading. In particular, studies show that processing a two-character word in a sentence benefits more from parafoveal preview of a nonword created by transposing rather than replacing its two characters. One issue that has not been investigated is whether the contextual predictability of the target word influences this processing of character order information. However, such a finding would provide novel evidence for an early influence of context on lexical processing in Chinese reading. Accordingly, we investigated this issue in an eye-movement experiment using the boundary paradigm and sentences containing two-character target words with high or low contextual predictability. Prior to the reader’s gaze crossing an invisible boundary, each target word was shown normally (i.e. a valid preview) or with its two characters either transposed or replaced by unrelated characters to create invalid nonword previews. These invalid previews reverted to the target word once the reader’s gaze crossed the invisible boundary. The results showed larger preview benefits (i.e. a decrease in fixation times) for target words following transposed-character than substituted-character previews, revealing a transposed-character effect similar to that in previous research. In addition, a word predictability effect (shorter fixation times for words with high than low predictability) was observed following both valid and transposed-character previews, but not substituted-character previews. The findings therefore reveal that context can influence an early stage of lexical processing in Chinese reading during which character order is processed flexibly.

     

Cognitive modeling analysis of decision-making processes in cocaine abusers

This article examines the theoretical basis of decision-making deficits exhibited by cocaine abusers in a laboratory decision-making task first described by Bechara, Damasio, Damasio, and Anderson (1994). A total of 12 male cocaine abusers and 14 comparison subjects performed the task, and the cocaine group performed significantly worse than the comparison group. A cognitive modeling analysis (Busemeyer & Stout, 2002) was used to estimate three parameters that measure importance of the cognitive, motivational, and response processes for determining the observed performance deficit. The results of this analysis indicated, for the first time, that motivational and choice consistency factors, but not learning/ memory were mainly responsible for the decision-making deficit of the cocaine abusers in this task.     

A psychophysical measure of attention deficit in children with attention-deficit/hyperactivity disorder

The authors explored the temporal mechanism of attention deficit in children with attention-deficit/hyperactivity disorder (ADHD). In rapid serial visual presentation tasks in which two targets (T-sub-1 and T-sub-2) were presented in close temporal proximity among distractors, participants tried to identify T-sub-1 and detect T-sub-2 in one (dual-task) experiment and only to detect T-sub-2 in a second control (single-task) experiment. The sensitivity of T-sub-2 detection was analyzed using signal detection theory. The attentional blink--the impairment in T-sub-2 detection following the identification of T-sub-1--was increased in magnitude and protracted in the patients. Moreover, some ADHD children appeared to have a blink largely normal in magnitude but temporally displaced toward a later time. The authors hypothesize that a slower closing of the attention gate may mediate this specific attention impairment in ADHD children.     

Cross- and within-cultural variations in children's understanding of distance, time, and speed interrelationships: a follow-up study

A problem with interpretations of differences in mathematic achievement between students from Asian countries and those from the United States is the seemingly implicit assumption of the cultural homogeneity of Asian societies. Researchers rarely measure the effects of variables within cultures that are hypothesized to be related to differences across cultures. In the present study, the authors examined the effects of socioeconomic status (SES) and quality of instruction on Chinese students' (1st, 3rd, and 5th grades) understanding of distance, time, and speed. The results indicated that (a) low SES in China can impede the development of children's mathematical cognition and (b) higher SES does not guarantee better performance. The implication is that the gap in mathematical performance between socioeconomically advantaged and disadvantaged children can be narrowed or even eliminated through instructional practices that focus on the systematic training of children's mathematical thinking.