Some problems of Wilson's disease

The Leipzig Center for Wilson's Disease in the GDR is charged with the registration and diagnosis of all homozygous Wilson gene carriers, the clarification of all suspected cases, including the heterozygote test, and the co-ordination of long-term treatment. At present, there are 78 recorded Wilson gene carriers living. On the basis of our own comprehensive observations and investigations over prolonged periods of time, questions concerning pathogenesis, genetics, diagnosis and therapeutic measures, including their side-effects, are dealt with.     

Treatment of handwriting problems utilizing EMG biofeedback training.

The effects of EMG biofeedback training on cursive handwriting were investigated for 4 girls and 5 boys in Grade 4. A significant reduction in EMG between the first baseline session and the last training session was obtained. Four of 5 characteristics of handwriting improved significantly. The need for carefully designed research comparing EMG biofeedback training and relaxation training was indicated. A self-control factor in handwriting was hypothesized.     

Hyperactivity and related behavioral characteristics in a sample of learning disabled children.

64 learning disabled and 12 minimal brain-damaged children were evaluated by their teachers on 11 categories of behavior. Analysis showed that behavioral characteristics associated with hyperactivity did not differentiate among subjects. Teachers rated poor motor coordination as the outstanding trait of this sample.     

A new Visual Aesthetic Sensitivity Test (VAST): II. cross-cultural comparison between England and Japan

A comparison was made of the scores of 171 Japanese boys and 156 Japanese girls, and of 204 English boys and 165 English girls, on the Visual Aesthetic Sensitivity Test. Also compared were 145 male and 163 female Japanese students, with 38 male and 73 female English students. Japanese children had scores significantly higher than English children, while Japanese students had scores significantly lower than English students. There was little evidence of age increments in score for either group of children. Difficulty levels of the 42 item-pairs were very similar in the two cultures, as were internal (split-half) reliabilities. It is concluded that cultural differences between the two countries, as far as visual aesthetic appreciation is concerned, seem at best minimal.     

Influence of LSD and 5-methyoxy-N,N,-dimethyltryptamine on the RNA synthesis in the cell nuclei of rat's brain]

The influence of LSD and 5-methyoxy-N.N.-dimethyltryptamine (MeODMT) on the RNA synthesis was verified in cell nuclei from rat's brain. LSD and 5-MeODMT inhibited the RNA synthesis within the test period of 30 minutes. This inhibition possibly participates in adaptive neuronal processes occurring in the course of psychoses.     

Problems and prospects in group psychotherapy research

The scientific basis of psychotherapeutic findings involves a number of difficulties which are above all connected with the insufficient state of basic research in this field. In this situation, significant advances can only be expected on the basis of a systematic long-term investigation and research programme. This applies in particular to the problems of personality and efficiency diagnostics and to group process research. On the basis of some intermediate results, it is shown that by the combined and systematic use of procedures a number of possibilities for the differentiated recording of the complex processes in therapeutic groups can be obtained.     

Differential indication of trimipramine - results of a controlled multiclinical study]

The antidepressants trimipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective und psychomotoric symptoms. The panthymoleptic action of trimipramine and other antidepressants is discussed with reference to these results. Trimipramine influences psychotic states, especially if in depression anxiety is combined with agitation, also in hypochondriac forms of depression.     

Age-of-acquisition effects in lexical and episodic memory tasks

This paper reports four experiments on the effects of word age of acquisition in verbal tasks. In all cases, multiple-regression analysis was used to assess the relative effects of age as opposed to other potentially relevant word attributes. Experiments 1 and 2 concerned lexical memory tasks. In Experiment 1, picture naming speeds were found to be mainly determined by picture codability and name age of acquisition. In Experiment 2, it was found that when subjects produced words in response to bigram cues, early acquired target words were more likely to be produced than later acquired words, even when frequency and other word attributes were taken into account. The remaining two experiments dealt with the episodic memory tasks of free recall and recognition. No age effects were found in these tasks. It was concluded that early age of acquisition facilitates retrieval from lexical memory but has no significant effect in episodic memory tasks.