The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

The lateral coding of rotations: a study of the simon effect with wheel-rotation responses

A number of experimental studies have consistently shown the locus of spatial S-R compatibility effects to be the selection of the response within an abstract memory code. The purpose of the present study was to test, in the particular case of wheel rotations, the general proposition that any response that a subject internally codes in terms of left and right may be interfered with by the lateral location of the stimuli in a Simon paradigm. Experiment 1 showed that the auditory Simon effect occurred in a task where the subjects had to rotate a steering wheel bimanually either clockwise or counterclockwise according to sound pitch, despite the fact that responses of this kind are undefined with respect to laterality. Experiment 2 confirmed this result in a unimanual rotation condition and suggested that the ear-rotation compatibility effect may be added to the effect of a biomechanical factor, pronation versus supination, supporting the idea of an abstraction motor code. In Experiment 3, subjects rotated the steering wheel with their hands on the lowest part of the wheel. When the response movement made the spot of a C.R.T. move laterally in accordance with the performed rotation, the subjects coded their response directly in terms of its effect on the visual display. For subjects not receiving visual feedback, no compatibility effect occurred. however, the individual data were compatible with the notion that some subjects in this group coded their responses in terms of wheel rotations, and others in terms of hand movements.     

Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects

Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.     

The sociodynamogram--a contribution to the objectivization of group process

Two simple sociometric techniques for practical use are described which are derived from the data given in the sociogram. Compared with the conventional sociogram, the group rank score we use everyday therapy has the advantage that it can be published. It permits members of the group to better identify the social situations which cause specific psychic impulses. The sociogram is reserved for the therapist. In our opinion the sociodynamogram has certain advantages over both methods because it provides an insight into spheres which are inaccessible in the sociogram and group rank score.     

The dimensionality of attributions of causality and responsibility for an accident

Effects of the dimensionality of responsibility and causality attributions were investigated. An accident was described. Subjects cued to respond with causality attributions increased their attributions with event severity. Subjects cued to respond with moral responsibility attributions decreased attributional levels with increasing severity. Assignments of guilt varied specifically with the cued attributional concept.     

Mouse killing in rats induced by lesions of the medial hypothalamus or medial accumbens: short-term preoperative exposure to a mouse does not suppress the killing

Rats were either exposed or not exposed to a mouse in their living cage for a 48-hr period. At the end of this time a bilateral lesion was made in the medial accumbens region or in the medial hypothalamus. When tested 2 days postoperatively, the killing frequency among rats that had been exposed to mice preoperatively was not significantly lower than that of rats that were not preoperatively exposed. The ineffectiveness of preoperative experience in suppressing the mouse killing induced by medial accumbens and medial hypothalamic lesions is similar to that found previously with dorsal-median raphe lesions and olfactory bulb lesions and is in contrast to the ease with which preoperative experience prevents mouse killing induced by septal lesions and serotonergic lesions induced by 5,7-dihydroxytryptamine.     

Strategy changes in human contingency judgments as a function of contingency tables.

Judgment strategies of 169 undergraduate students on problems to judge the contingency between two binary events were identified by the method of rule-based analysis to clarify whether or not the strategies the subjects used would be affected by the concrete nature of the contingency table. Problems were constructed along two factors: total cell frequency and width of range of objective contingencies. Although the factor of total cell frequency had no effect on subjects' strategies, the number of subjects who changed strategies corresponding with problem instances increased when the objective contingencies were set closer to zero or when problems became more difficult. These results are discussed in the context of previous studies of this issue in the literature.     

The Stroop congruency effect is more observable under a speed strategy than an accuracy strategy

Naming the ink color of an incongruent color word (e.g., RED printed in green) usually takes longer than naming the ink color of a color bar. However, when the ink matches the word (e.g., RED printed in red), naming tends to be faster. These phenomena are known as the STroop interference effect and the Stroop congruency effect, respectively. Although the interference effect has been robust and reliable across studies, the congruency effect tends to be elusive. It was hypothesized that this variation in outcomes might be related to subjects' response strategy. The experiment conducted to test this hypothesis induced either a speed or an accuracy strategy in two separate groups of subjects. Significant interference effects were found for both groups and the magnitudes did not differ. At the same time, the congruency effect was observed in the speed group but not in the accuracy group. These results suggest that researchers who wish to observe and study the Stroop congruency and interference effects should place special emphasis on speed. Implications of the study for a model of the Stroop effect are also discussed.