In vitro reinforcement of hippocampal bursting: a search for Skinner's atoms of behavior.

A novel "in vitro reinforcement" paradigm was used to investigate Skinner's (1953) hypotheses (a) that operant behavior is made up of infinitesimal "response elements" or "behavioral atoms" and (b) that these very small units, and not whole responses, are the functional units of reinforcement. Our tests are based on the assumption that behavioral atoms may plausibly be represented at the neural level by individual cellular responses. As a first approach, we attempted to reinforce the bursting responses of hippocampal units in a highly reduced brain-slice preparation with local micropressure applications of behaviorally reinforcing dopaminergic drugs. The same injections were administered independently of bursting to provide a "noncontingent" control for nonspecific stimulation or facilitation of firing. It was found that the bursting responses of individual CA1 pyramidal neurons may be progressively facilitated in a dose-related manner by response-contingent (but not noncontingent) injections of dopamine itself, the dopamine D1-preferring agonist SKF 82958, the D3-preferring agonist quinpirole, and the D2-like selective agonist (+)-4-propyl-9 hydroxynapthoxazine. These findings support the conclusion that unit bursting responses can be reinforced in vitro in hippocampal slices, and they further suggest that the same dopamine receptor subtypes are involved in both cellular and behavioral operant conditioning. The results thus provide indirect support for Skinner's atoms-of-behavior hypothesis.     

肿瘤治疗模式的哲学思考

外科手术往往是肿瘤治疗的首选方法,对于不能手术或已丧失手术机会者才考虑放疗,化疗。近年来,出现了诱导分化和凋亡等治疗手段,且在某些肿瘤的治疗上已取得了可喜的效果,这点新概念,新手术的出现,使得以往的肿瘤治疗模式受到了冲击,从以人为本,预防为主的哲学思想出发,我们似科可以提出这样的肿瘤治疗模式,诱导分化→启动凋亡→手术,放疗,化疗。     

正常和弱视者立体和形状视觉感知时间的差异

在速示器,以随机点立体图对为刺激,测量了正常和弱视者的立体视和形状视感知时间。实验表明:正常被试需要大约100ms感知深度,110ms或更长时间感知形状。这二种感知时间与刺激视差的种类和大小无关。弱视者需要比正常人较长的时间达到立体和形状的视感知。这二种感知时间的差别,弱视者也大于正常人。视锐度和立体视范围均恢复到正常的弱视者,以上二种感知时间,可以达到正常人范围,也可能显著地大于正常人。     

An adaptive reference/test paradigm: Application to pulsed fluoroscopy perception

We developed an adaptive forced-choice method whereby reference and test presentations were alternated in order to minimize effects from variables such as subject attention level. In our demonstration example of an X-ray fluoroscopy perception study, we measured detectability of low-contrast objects in noisy image sequences and determined X-ray dose levels for equivalent detectability of identical contrasts for a new test acquisition method (fluoroscopy at 15 acq/sec) as compared with a reference (conventional fluoroscopy at 30 acq/sec). In preliminary experiments, we found a dose savings with the test method. We derived parameter uncertainties for the adaptive procedure and demonstrated their applicability with Monte Carlo simulations. Repeated experiments on a single subject demonstrated reduced standard errors due to the reduction of day-to-day variations. It is believed that the method can be applied in a variety of situations in which one needs to compare perception measurements.     

谈判心理研究发展述评

20世纪60年代和70年代,谈判是社会心理学研究中一个非常活跃的领域。但70年代后期,谈判研究因认知心理学的兴起而衰落。80年代早期,谈判这一领域在心理学研究中再度兴起,谈判的行为决定研究成为这一时期主流。但90年代后期谈判的社会心理学研究复兴,一度消失的社会因素再次成为谈判研究的热点。该文回顾了西方谈判心理研究的发展,探讨了导致谈判心理研究发展中所发生的诸多变化的原因,并展望了其将来的发展方向。     

视知觉无意识加工的脑机制及其研究进展

本文从脑的解剖和功能结构、神经网络联结及其突触活动基础角度,对视知觉无意识加工脑内可能存在的信息加工方式进行了探讨。视知觉无意识加工既是一个不同特征在大脑的不同区域被平行分布加工的过程,也是一个涉及正向和反向的信息序列加工及意识与无意识相互转化的过程。     

幸福感的中西差异:自我建构的视角

幸福感本质上是文化定位的,然而以往的幸福感研究大都只关注中西幸福感的共同性,而很少考虑两者的差异性。以中西自我建构的差异代表个人—集体主义文化的差异,通过对比中西自我建构与幸福感的差异,发现中西幸福感在本源、意义、联系与时间四个维度存在显著差异。中国人的幸福感具有明显的和谐性、价值性、社会性与未来性四个特征。中国人幸福感四个特征的确认为我国幸福感理论和应用研究的本土化提供了一个有价值的视角。     

Personal and impersonal stimuli differentially engage brain networks during moral reasoning

Moral decision making has recently attracted considerable attention as a core feature of all human endeavors. Previous functional magnetic resonance imaging studies about moral judgment have identified brain areas associated with cognitive or emotional engagement. Here, we applied graph theory-based network analysis of event-related potentials during moral decision making to reveal the personal/impersonal distinction in the organization of functional connectivity. Our results indicated that the personal task had more larger long-range connections involved in frontal regions and the right hemisphere, and higher network efficiency of some frontal electrodes such as F2 than the impersonal. These might be related to brain resource reorganization contributing to efficient conflict resolution. These findings provide new insights into neural mechanisms of moral dilemmas.     

Enhanced visible-light absorption in heavily nitrogen-doped TiO2

Heavy nitrogen doping of TiO₂ thin films has been achieved by ion-beam-assisted deposition. The heavily doped films have a distorted anatase crystal structure and show an increase in visible-light absorption compared to films with only light nitrogen doping. The enhanced absorption is shown by a first-principles density-functional calculation to result from an electronic band-gap narrowing, in contrast to the appearance of isolated N 2p states above the valence-band maximum that occur with light nitrogen doping.     

方法影响结果?方法变异的本质、影响及控制

方法变异是由研究方法导致的系统误差.方法变异既可能产生结构层面的影响,也可能产生题目层面的影响;既可能影响单个结构的测量,也可能影响用相同方法研究的多个结构之间的关系,还可能影响用相同方法研究的多个研究之间的关系,进而影响到相关领域的理论建构.在控制方法变异时,可采取过程控制法和统计控制法,最好先用过程控制法.