记忆训练对改善少年、青年和老年人认知功能的作用

本工作采用“位置法”(method of loci)对24例少年、24例青年和22例老年被试进行了记忆训练研究。以毕生发展的观点比较认知训练对改善不同年龄人记忆的作用,进而探讨发展的认知功能储备能量的年龄差异和训练的迁移效应。结果表明认知干预措施可在一定程度上改善老年人的记忆,同时也显示了在发展的储能和对图形的迁移效应方面,老年人明显不如青、少年,而青年与少年则彼此相近。     

不同学习方式下习得性长时程突触增强形成的特点

一般认为,突触传递的长时程增强(Long-term potentiation,LTP)可能是学习和记忆的神经基础。我室的系列工作表明,大鼠在条件性行为的建立中,海马齿状回、CA_3、CA_1区均出现LTP样变化,并将之称为习得性LTP(Learning-de-pendent LTP),而且发现每次训练作业后突触效应的增强,经一段时间(4小时)后就     

Application of the stagnant stage concept for monitoring Mn partitioning at the austenite-ferrite interface in the intercritical region for Fe–Mn–C alloys

The length of the stagnant stage during the new ferrite growth starting from a mixture of austenite and ferrite has been investigated for a Fe-0.17Mn-0.023C (wt%) alloy. It was found that the stagnant stage depends on the thermal path followed to create the mixture, and deduce that the tie-lines for austenite to ferrite transformation are quite different from those for ferrite to austenite transformation. The length of the stagnant stage is determined by the very local partitioning effect at the interface, and it can be used as a tool to monitor the Mn partitioning.     

A study of the greater male variability hypothesis in creative thinking in Mainland China: Male superiority exists

This study tested the greater male variability hypothesis in creative thinking with a Chinese student sample in Mainland China. The Test for Creative Thinking-Drawing Production (TCT-DP) was administered to 627 Chinese adolescent boys (n = 332) and girls (n = 295). Results using the boy/girl variance ratio (VR) generally supported the hypothesis that boys have greater variability than girls in creativity test performance. However, results using the boy/girl ratios from different regions of the creativity score distribution revealed a pattern of male superiority. While boys significantly outnumbered girls in the higher extremes, girls tended to outnumber boys in the central region and the lower extremes. Results from an analysis of the means lent further support to the findings of male superiority. Plausible explanations for greater male variability and male superiority in Mainland China are proposed. The theoretical and practical implications of the findings are discussed.     

原发性开角型青光眼局部药物治疗的比较及决策最优化

通过对目前治疗原发性开角型青光眼局部降眼压药物的作用机制、治疗效果、不良反应、药品价格及使用方便程度进行综合的比较分析,运用比较治疗学的理论和方法来指导和规范该类青光眼局部药物治疗的临床决策,以期提高治疗效果、减少并发症、降低费用及提高患者的生存质量。     

Induction, overhypothesis, and the origin of abstract knowledge. Evidence from 9-month-old infants

Human cognition relies on the ability to extract generalizable knowledge from limited evidence. One type of inductive learning, overhypothesis formation, allows learners to make inferences that take them beyond the limits of direct experience, leading to the creation of abstract knowledge. The developmental roots of this ability have yet to be investigated. We report three experiments examining whether 9-month-old infants are capable of forming overhypotheses. Our results show that when given evidence about a few objects in some category, infants formed a second-order generalization about categories in general. These findings provide evidence that infants possess a powerful mechanism for inductive learning-a mechanism that may be applied to many domains and that can account for the development of many inductive biases later on.     

Integrating physical constraints in statistical inference by 11-month-old infants

Much research on cognitive development focuses either on early-emerging domain-specific knowledge or domain-general learning mechanisms. However, little research examines how these sources of knowledge interact. Previous research suggests that young infants can make inferences from samples to populations (Xu & Garcia, 2008) and 11- to 12.5-month-old infants can integrate psychological and physical knowledge in probabilistic reasoning (Teglas, Girotto, Gonzalez, & Bonatti, 2007; Xu & Denison, 2009). Here, we ask whether infants can integrate a physical constraint of immobility into a statistical inference mechanism. Results from three experiments suggest that, first, infants were able to use domain-specific knowledge to override statistical information, reasoning that sometimes a physical constraint is more informative than probabilistic information. Second, we provide the first evidence that infants are capable of applying domain-specific knowledge in probabilistic reasoning by using a physical constraint to exclude one set of objects while computing probabilities over the remaining sets.     

基因研究中的知情同意之惑

知情同意作为生命伦理的重要原则,在基因研究中同样占据重要的地位,由于基因研究中知情同意的异质性,在基因研究中面临着诸如如何理解其知情同意的异质性、群体知情同意、基因知情与基因隐私、利益冲突等问题.通过分析基因研究中知情同意的特殊性,综合国内外此领域的已有研究,运用理论联系实际的方法,得出结论认为,只有正确区分基因知情与基因隐私的权利主体,用伦理规范来解决利益冲突,在发展中不断完善知情同意,才能够取得科技与伦理的共赢.     

伤害回避的脑机制及其生物基础

伤害回避是指个体对厌恶刺激信号做出强烈的反应,并学会被动地回避惩罚的一种倾向,这一倾向使得个体反复思考未来的结局,并谨慎小心地对待不确定情景中的事件,进而更有可能诱发情感障碍。伤害回避涉及的神经网络包括三个子网络,即额顶叶-前扣带皮层的连接、皮层-杏仁核的连接和白质通道的结构性连接,这三个子网络分别与羞怯感-易疲劳性、预期担心以及不确定环境中的害怕情绪有关。而其生物基础则包括单一基因多态性和基因多态间的交互作用。今后的研究应该集中在深化伤害回避神经网络与生物基础间的联合机制、研究三种及以上基因多态间的交互作用、考察其他因素对基因效应的调节作用、注重伤害回避四种亚型相关神经网络之间的连接、探讨5-HT4等其他几种5-羟色胺受体多态性与伤害回避的关系以及分析伤害回避内部机制在抗抑郁治疗中的作用等方面。     

"旧人"的否弃和"新人"的形塑--论马克思对人的价值形象的设计

任何关于人的理论都有自己理想的人的价值形象。它既是观察和评价现实生活的标准,也是实践活动所追求的目标。本文旨在将马克思所设计的人的价值形象从他复杂的理论构造中剥离出来。马克思关于人的理论以批判性的建构为鲜明特色,他对理想的人的价值形象的设计跟他对人的实际生活状况的否定是相辅相成的,亦即对“旧人”的否弃和对“新人”的塑形是同时进行的。这个“新人”的主要内涵如下：人应该是民主制度下的人。应该是追求现实幸福的人,应该是自由地自觉地活动的人,应该是全面发展的人。