系统性综述干细胞来源的生物材料采集的供者健康风险

通过检索国内外6个文献数据库以获取发表于2010年1月~2020年7月研究相关的文献,并对干细胞来源的生物材料采集的供者健康风险进行了系统性综述。50篇相关文献分析显示,在许多情况下,生物材料采集可使供者承受健康风险,包括麻醉、粒细胞集落刺激因子或促排卵药物使用、中心静脉导管放置、穿刺等带来的风险。此外,生物材料采集还可影响供者的心理健康。根据上述发现,建议干细胞来源的生物材料采集需要严格的伦理管控,以保障生物材料供者的健康权益。

     

医学教育中医师职业精神评估方法初探

医师职业精神是每个医师所必须达到并表现出来的一个基本胜任力,相应也是医学职业教育的重要内容。对医师职业精神的细化和评估是促进医师职业精神建设的基础,各种评估方法也是促进职业精神教育的基本工具。国外目前主要的医师职业精神评估方法为伦理知识和道德推理检测,定性、定量的观察评价。观察评估主体包括自评和不同来源的他评。结合医学教育的不同阶段选用合理的职业精神评估方法,可为国内医师职业精神的建设和教育提供参考和借鉴。     

反应抑制的训练:内容、效果与机制

近期的研究发现,个体的反应抑制能力具有一定的可塑性。研究者多采用双盲随机对照实验设计,训练的对象包括儿童、成人和特殊群体,研究者通过Go/Nogo、Stop-signal等任务进行为期1周至3周,45至7200试次不等的抑制控制能力训练,并结合行为、脑电以及脑成像等技术对训练效果进行评估,研究结果发现,接受了抑制控制训练的个体其抑制能力得到提升,并伴随脑神经活动的变化。另外,研究者发现,抑制控制能力的训练效果还可以迁移至个体日常生活中的表现。但是,也有些研究并未发现抑制控制训练的效果。训练任务的设置,评估任务的选择以及被试反应策略的差异等因素可能会影响训练的效果。抑制控制训练引发行为与大脑活动的变化可能是由于训练导致了个体建立了自上而下有意识的抑制控制模式和自下而上的自动抑制模式。反应抑制和冲突抑制可塑性的比较,儿童与老年人抑制功能的训练以及训练效果的追踪研究将成为该领域日后研究的重点问题。     

Neural bases of binocular rivalry

During binocular rivalry, conflicting monocular images compete for access to consciousness in a stochastic, dynamical fashion. Recent human neuroimaging and psychophysical studies suggest that rivalry entails competitive interactions at multiple neural sites, including sites that retain eye-selective information. Rivalry greatly suppresses activity in the ventral pathway and attenuates visual adaptation to form and motion; nonetheless, some information about the suppressed stimulus reaches higher brain areas. Although rivalry depends on low-level inhibitory interactions, high-level excitatory influences promoting perceptual grouping and selective attention can extend the local dominance of a stimulus over space and time. Inhibitory and excitatory circuits considered within a hybrid model might account for the paradoxical properties of binocular rivalry and provide insights into the neural bases of visual awareness itself.     

大学生对心理健康必备能力的认知

本研究以200名大学生为被试,以访谈及问卷的方式对大学生心理健康必备能力的认知进行了调查研究,并建立了大学生心理健康必备能力认知结构模型,结果表明:大学生所认知的自己心理健康必备能力由自我调控、社会应对、学习和人际交往这四个方面的能力组成,它们彼此独立,但又相互关联。     

Bidirectional Mediating Role of Loneliness in the Association Between Shyness and Generalized Pathological Internet Use in Chinese University Students: A Longitudinal Cross-Lagged Analysis

Abstract

This 1-year longitudinal study examined the bidirectional mediating role of loneliness in the association between shyness and generalized pathological Internet use (GPIU) in a sample of 291 Chinese university students (143 men, mean age =?19.07?years). A fully cross-lagged panel design was used in which shyness, loneliness, and GPIU were assessed at 3 time points separated by 6-month intervals (named T1, T2, and T3). The results indicated that relationships among shyness, loneliness, and GPIU were dynamic and bidirectional. Specifically, T1 shyness positively predicted increased T2 loneliness, T2 shyness positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 shyness. Additionally, T1 GPIU positively predicted increased T2 loneliness, T2 GPIU positively predicted increased T3 loneliness, and T2 loneliness positively predicted increased T3 GPIU. Loneliness was found to play a bidirectional mediating role in the association between shyness and GPIU. Specifically, T1 shyness and T3 GPIU were mediated through increased loneliness at T2, and T1 GPIU and T3 shyness were mediated through increased loneliness at T2. Furthermore, relationships among shyness, loneliness, and GPIU were the same across the 2 groups, with the strength of relationships being stronger for men.     

Diagnostics of Robust Growth Curve Modeling Using Student's t Distribution

Growth curve models with different types of distributions of random effects and of intraindividual measurement errors for robust analysis are compared. After demonstrating the influence of distribution specification on parameter estimation, 3 methods for diagnosing the distributions for both random effects and intraindividual measurement errors are proposed and evaluated. The methods include (a) distribution checking based on individual growth curve analysis; (b) distribution comparison based on Deviance Information Criterion, and (c) post hoc checking of degrees of freedom estimates for t distributions. The performance of the methods is compared through simulation studies. When the sample size is reasonably large, the method of post hoc checking of degrees of freedom estimates works best. A web interface is developed to ease the use of the 3 methods. Application of the 3 methods is illustrated through growth curve analysis of mathematical ability development using data on the Peabody Individual Achievement Test Mathematics assessment from the National Longitudinal Survey of Youth 1997 Cohort (Bureau of Labor Statistics, U.S. Department of Labor, 2005).     

Computer-Mediated Communication Versus Vocal Communication and the Attenuation of Pre-Interaction Impressions

Conflicting theoretical approaches yield divergent predictions about the effects of telephones versus computer-mediated communication (CMC) in the persistence or dissipation of pre-interaction expectancies. Moreover, different theoretical orientations and their underlying assumptions often invoke different methodologies, which can bias the results of research. The current studies articulate and assess rival hypotheses from alternative theoretical paradigms to uncover how CMC and vocal communication affect interpersonal impressions. Methodological issues in past CMC research are evaluated that limit the generalizability of previous findings in the area. Experiments employing alternative assumptions and methods indicate that CMC is functionally equivalent to vocal communication in its ability to ameliorate expectancies and that in some cases it can be superior in transmitting positive impressions.