Differential Effect of TEA on Long-Term Synaptic Modification in Hippocampal CA1 and Dentate Gyrus in vitro

The effectiveness of tetraethylammonium (TEA) and high-frequency stimulation (HFS) in inducing long-term synaptic modification is compared in CA1 and dentate gyrus (DG) in vitro. High-frequency stimulation induces long-term potentiation (LTP) at synapses of both perforant path-DG granule cell and Schaffer collateral-CA1 pyramidal cell pathways. By contrast, TEA (25 mM) induces long-term depression in DG while inducing LTP in CA1. The mechanisms underlying the differential effect of TEA in CA1 and DG were investigated. It was observed that T-type voltage-dependent calcium channel (VDCC) blocker, Ni²⁺ (50 μM), partially blocked TEA-induced LTP in CA1. A complete blockade of the TEA-induced LTP occurred when Ni²⁺ was applied together with the NMDA receptor antagonist, D-APV. The L-type VDCC blocker, nifidipine (20 μM), had no effect on CA1 TEA-induced LTP. In DG of the same slice, TEA actually induced long-term depression (LTD) instead of LTP, an effect that was blocked by D-APV. Neither T-type nor L-type VDCC blockade could prevent this LTD. When the calcium concentration in the perfusion medium was increased, TEA induced a weak LTP in DG that was blocked by Ni²⁺. During exposure to TEA, the magnitude of field EPSPs was increased in both CA1 and DG, but the increase was substantially greater in CA1. Tetraethylammonium application also was associated with a large, late EPSP component in CA1 that persisted even after severing the connections between CA3 and CA1. All of the TEA effects in CA1, however, were dramatically reduced by Ni²⁺. The results of this study indicate that TEA indirectly acts via both T-type VDCCs and NMDA receptors in CA1 and, as a consequence, induces LTP. By contrast, TEA indirectly acts via only NMDA receptors in DG and results in LTD. The results raise the possibility of a major synaptic difference in the density and/or distribution of T-type VDCCs and NMDA receptors in CA1 and DG of the rat hippocampus.     

风险情景中的机会和威胁认知

随着近年来社会经济的高速发展 ,人们面临着越来越多的风险问题。该研究的目的在于深入分析个体成就动机、风险情景中的行为反应方式以及机会 -威胁认知三者之间的关系。研究采用问卷设计 ,由成就动机量表、抽彩游戏和机会 -威胁问卷三部分组成。被试来自北京和重庆地区的三所高校 (N =2 6 2 )。结果发现 :(1)成就动机中的“回避失败”变量对个体在风险情景中的反应方式以及机会 -威胁认知有显著性的影响 (p <0 0 5 ) ;(2 )机会 -威胁认知水平不同的个体在风险情景中的反应方式有着显著性的差异 (p <0 0 1) ,机会认知与行为变量的相关达到了显著性水平 (p <0 0 5 ) ;(3)四组被试分别表现出高机会 -低威胁等 4种认知组合 ,因此机会与威胁认知可能存在于两维空间     

工作家庭冲突对电讯人员工作倦怠和心理健康的影响

采用工作家庭冲突问卷、工作倦怠问卷（MBI-Gs）和一般健康状况问卷（GHQ-12）调查了某国营电讯公司526名员工。中介回归分析（Mediating Regressin Analysis）的结果显示,工作家庭冲突及其两个子成分（工作浸扰家庭和家庭浸扰工作）都对心理健康具有显著的负向影响;工作倦怠对工作家庭冲突影响心理健康具有完全中介作用;具体而言,工作浸扰家庭对心理健康的影响受情绪衰竭和玩世不恭的完全中介;家庭浸扰工作对心理健康的影响受工作倦怠所有三个子成分的完全中介。     

体育专业大学生网络心理特点研究

目的:探讨体育专业大学生网络心理的特点。方法:采用自编大学生网络心理问卷,对某省236名体育专业大学生和331名非体育专业大学生的网络心理进行调查和比较。结果:(1)体育专业大学生网络喜好程度显著低于非体育专业大学生。(2)体育专业大学生对网络依恋程度低于非体育专业大学生。(3)体育专业大学生对网络人际交往依赖程度低于非体育专业大学生。(4)体育专业大学生在上网目的性上表现为"学习需要"等,非体育专业大学生上网是为了"寻求自信"等。     

Aggression and school social dynamics: The good, the bad, and the ordinary

A social dynamics perspective of aggression in school is presented. This framework focuses on the role of natural social processes in the establishment and maintenance of aggressive behavior in the school context. The five articles in this special issue are briefly reviewed and a synthesis of their contributions for understanding the social dynamics of aggression in school is underscored. Future research and intervention implications are also discussed. The need for examining the role of school social dynamics in conducting social skills interventions, functional behavioral assessments, and the development of positive behavioral support plans is emphasized.     

基督教神学与生活领域:从凯珀到斯塔克豪思

本文分析荷兰神学家亚伯拉罕·凯伯和美国神学家马克斯?斯塔克豪思在理解和促进神学与社会生活关联上各自的贡献:前者以"普遍恩典"和"领域主权"的观念为中心,后者则以"全球化与恩典"为考察重点。两者的公共神学存在着一定的思想联系,本文将进一步探析凯伯对斯塔克豪思的影响。这一研究意在表明公共生活领域对于神学思考的重要性,而时代的处境会提出神学必须面对的不同公共议题及其指向的特定神学信念和方法。     

To change or not to change: A matter of decision maker’s role

The status quo effect derived from loss aversion is common in decision making. However, we propose that advisors (vs. personal decision makers) are less susceptible to such an effect because they are less loss-averse. The difference in loss aversion between personal decision makers and advisors is reflected in both the query order and content. Compared to advisors, personal decision makers produce more queries favoring the status quo, at an earlier time, than those favoring the new option. As hypothesized, the status quo effect was observed among personal decision makers, but not among advisors (Studies 1 and 2). Query order and content were found to mediate the impact of decision maker’s role on the status quo effect (Study 2). When personal decision makers and advisors made queries in the same order (Study 3) or of the same content (Studies 4a and 4b), the difference between self–other decision making disappeared.     

贝叶斯推理的三重加工心智模型

自二十世纪60年代Edwards首次用实验研究人类推理是否遵循贝叶斯规则以来,国内外贝叶斯推理研究取得了长足的发展,但也出现了一些困境:对影响贝叶斯推理的客体因素和主体因素研究未成体系,解释理论莫衷一是。未来的研究应该重新审视客体与主体的关系,系统整合和多角度分析影响贝叶斯推理的因素,尝试以三重加工心智模型解释人类贝叶斯推理行为,并对以往的解释理论进行融合,从而更好地揭示人类不确定性决策的本质。     

因果影响与函数式依赖:从逻辑的视角分析

近年来,关于如何刻画系统中变量间的相互依赖和相互影响在计算机以及哲学研究中激起了广泛讨论。其中非常经典的工作包括Pearl、Gales以及Halpern等逻辑学家和计算机科学家提出的因果模型和基于因果模型的因果逻辑。而最新Baltag与van Benthem的工作又提出了通过函数式依赖这一概念分析变量间影响的模型。本文将介绍并探讨这两种路径之间的关系,并且提出,在对Halpern等人的因果模型和逻辑做认知方面的扩充之后,我们能在这两种路径中找到更多共通之处。