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121.
The expression of the immediate early gene c-fos has been used extensively as a marker for neural activation in response to acute and chronic stressful stimuli in brain and spinal cord. The present study examined the expression of Fos protein in the brainstem nuclei of male and female gonadectomized mice in response to cold stress. Free-floating sections were processed immunohistochemically for Fos protein using standard avidin-biotin complex methods. The number of Fos-positive neurons in each nucleus was determined. Although the experiment was designed to look for gender differences, results were equivalent between females and males. After mice were exposed to a cold ambient temperature (4 degrees C) for 2 h, elevated numbers of Fos-positive neurons were counted in the medullary gigantocellular reticular nucleus, medullary raphe nucleus, nucleus of the solitary tract and in locus coeruleus. However, no elevated expression was found in nucleus ambiguus, nor in neurons of the A1 group, nor the C2 or C3 group. Similar to rats, these results with mice reveal a widespread arousal system in the lower brainstem activated by cold stress in both genders. These findings in gonadectomized mice have set the stage for investigations following hormonal and genetic manipulations. 相似文献
122.
Schmidt NB Storey J Greenberg BD Santiago HT Li Q Murphy DL 《Journal of abnormal psychology》2000,109(2):308-320
The present study evaluated the singular and interactive effects of a functional polymorphism (variation) in the serotonin transporter (5-HTT) gene and a psychological trait (anxiety sensitivity [AS], i.e., fear of arousal symptoms) in predicting subjective and physiological responses to a 35% carbon dioxide (CO2) challenge in a community sample (N = 72). Genotypes were divided into 2 groups in accord with prior research. Findings were partially supportive of the hypothesized risk model. These indicated that the Group L genotype (homozygous for the 1 allele), compared with the Group S genotype (homozygous for the s allele plus heterozygous individuals), predicted greater fearful response to the biological challenge. There was also an AS x Genotype interaction predicting heart rate variability (HRV) in response to the CO2, suggesting that high AS plus Group L status predicts decreased HRV. 相似文献
123.
We investigated the regulation of sequential action using a new paradigm. Participants learned a sequence of seven stimulus categories and then monitored for them during successive displays. All displays were instances of these categories, presented in pseudorandom order. On each trial, participants monitored for an instance of Category 1, pressed a key on a computer keyboard, then monitored for an instance of Category 2, pressed a key on the keyboard, and so on for all seven categories. Thus, a perfect trial contained exactly seven responses. Intrusion errors were classified as a function of ordinal distance from the current serial position ( n ). Fewer intrusion errors were made at near serial positions than at far ones, suggesting a gradient of lateral inhibition. In addition, more intrusions were made on n + 1 categories than n − 1 categories, suggesting greater availability of intended than completed goals. In accord with current models of sequential action, the results indicate lateral and self-inhibition as important mechanisms in regulation of sequential action. 相似文献
124.
Robert E. Lee Kathleen Burns Jager Jason B. Whiting Catherine T. Kwantes 《Contemporary Family Therapy》2000,22(1):81-90
Confirmatory factor analysis and regression analyses of the Beavers Interactional Scales did not appear to support the model offered by its developers, namely, several specified family attributes contributing respectively to two global factors of Family Competence and Family Style. Moreover, regression analysis indicated that only three of 12 items predicted raters' assessments of Global Family Health, and one of seven items predicted Global Family Style. Individuals interested in the family dynamic centripetal/centrifugal might best think of that as a unitary entity and rate it accordingly. 相似文献
125.
Deane-Peter Baker 《International Journal for Philosophy of Religion》2005,57(2):77-103
Alvin Plantingas Warranted Christian Belief is without questionone of the central texts of the Reformed epistemology movement. Critiques of Plantingas defence have been both multiple and varied. As varied as these responses are, however, it is my contention that many of them amount to the same thing. It is the purpose of this paper to offer an overview of the main lines of attack that have been directed as Plantingas project, and thereafter to show how many, if not most, of these objections can be understood as versions or aspects of the same criticism, what I call the Inadequacy Thesis. 相似文献
126.
Objectives: To understand the impact of physicians and patients religious/spiritual orientation on discussions of spiritual issues. Methods: We performed semi-structured interviews of 10 Missouri family physicians and 10 patients of these physicians, selecting subjects nonrandomly to represent a range of demographic factors, practice types, and chronic or terminal illness. We coded and evaluated transcribed interviews for themes. Results: Respondents expressed that similar belief systems facilitate patient–physician spiritual interactions and bring confidence to their relationships. Those holding dissimilar faiths noted limited ability to address spiritual questions directly. They cited significant barriers to spiritual interaction but considered that ecumenism, use of patient-centered care, and negotiation skills lessen these barriers. Conclusions: Our respondents view spirituality similarly to other aspects of the physician–patient relationship involving differing viewpoints. Where discordance exists, cross-cultural, patient-centered, diplomatic approaches facilitate spiritual discussions. 相似文献
127.
The lexical constituency model: some implications of research on Chinese for general theories of reading 总被引:13,自引:0,他引:13
The authors examine the implications of research on Chinese for theories of reading and propose the lexical constituency model as a general framework for word reading across writing systems. Word identities are defined by 3 interlinked constituents (orthographic, phonological, and semantic). The implemented model simulates the time course of graphic, phonological, and semantic priming effects, including immediate graphic facilitation followed by graphic inhibition with simultaneous phonological facilitation, a pattern unique to the Chinese writing system. Pseudocharacter primes produced only facilitation, supporting the model's assumption that lexical thresholds determine phonological and semantic, but not graphic, effects. More generally, both universal reading processes and writing system constraints exist. Although phonology is universal, its activation process depends on how the writing system structures graphic units. 相似文献
128.
Matthew Hoffman 《Jewish History》2005,19(1):65-78
The Russian Jewish intellectual, Chaim Zhitlovsky (1865–1943), a leading architect of secular Jewish culture and thought, was a central figure in the progressive Jewish intelligentsia of the late nineteenth and early twentieth century. In an essay written in 1927, Yidn un Yiddishkayt (Jews and Jewishness), he sought to define the secular essence of what he calls Yiddishkayt. This essay is not the first in Zhitlovskys long publicistic career in which he searches for new, secular definitions of Jewish identity and culture. But this essay differs, since it is marked by Zhitlovskys use of contemporary social scientific notions of race and racial traits to conceptualize what he believes constitutes Jewishness in a non-religious context, along with his adoption of the mystical Jewish concept of the pintele yid, the theory of an innate Jewishness embodied by a Jewish spark. Zhitlovskys desire to craft a truly secular theory of Jewish identity led him ironically to accept models of Jewish identity at odds with his stated larger vision. In turning to contemporary racial theory, as well as long nurtured mystical models of Yiddishkayt, Zhitlovsky reveals the wide range of ideological discourses that led him to innovative and controversial notions of modern Jewish identity. 相似文献
129.
执行功能中认知灵活性发展的研究进展 总被引:8,自引:0,他引:8
近十多年以来,执行功能已成为研究的热点和前沿。认知灵活性是执行功能的主要成分,它对个体能力发展和对环境适应的方面起着重要作用。该文从认知灵活性的本质、发展、研究方法及其与教育的关系进行探讨。 相似文献
130.