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101.
Ewan C. McNay Cecilia T. Ong Rory J. McCrimmon James Cresswell Jonathan S. Bogan Robert S Sherwin 《Neurobiology of learning and memory》2010,93(4):546-553
Insulin regulates glucose uptake and storage in peripheral tissues, and has been shown to act within the hypothalamus to acutely regulate food intake and metabolism. The machinery for transduction of insulin signaling is also present in other brain areas, particularly in the hippocampus, but a physiological role for brain insulin outside the hypothalamus has not been established. Recent studies suggest that insulin may be able to modulate cognitive functions including memory. Here we report that local delivery of insulin to the rat hippocampus enhances spatial memory, in a PI-3-kinase dependent manner, and that intrahippocampal insulin also increases local glycolytic metabolism. Selective blockade of endogenous intrahippocampal insulin signaling impairs memory performance. Further, a rodent model of type 2 diabetes mellitus produced by a high-fat diet impairs basal cognitive function and attenuates both cognitive and metabolic responses to hippocampal insulin administration. Our data demonstrate that insulin is required for optimal hippocampal memory processing. Insulin resistance within the telencephalon may underlie the cognitive deficits commonly reported to accompany type 2 diabetes. 相似文献
102.
The present study examined the moderating effect of Zhong Yong on the relationship between perceived creativity and innovation behaviour in Chinese companies. A total of 273 paired questionnaires were collected with employee self-rated creativity and Zhong Yong and supervisor-rated innovation behaviour. The results show that for people higher on Zhong Yong, their creativity was not correlated with innovation behaviour; for people less immersed in Zhong Yong, this correlation is significant. This finding provides a new insight into the effects of Zhong Yong on the creativity-innovation behaviour transformation processes. The implications for future research are also discussed. 相似文献
103.
本研究采用5(学习次数)×2(材料难度)被试内设计,考察材料难度和学习次数对即刻和延迟学习判断绝对准确性的影响。45名大学生被试参加实验,共收集有效数据37个。结果表明:(1) 即刻条件下,高、低难度词对都出现了练习伴随低估效应;(2) 延迟条件下,高、低难度词对均未出现练习伴随低估效应。对低难度词对的学习判断准确预测了回忆成绩,高难度词对则出现了练习伴随高估效应;(3) 随着学习次数的增加,不同难度词对在即刻条件下的练习伴随低估效应趋于消失,延迟条件下高难度词对的练习伴随高估效应趋于消失。 相似文献
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105.
LIU Xiang 《Frontiers of Philosophy in China》2014,9(2):213-228
In the chapter "The Adjustment of Controversies" in his eponymous work, Zhuangzi has the character Nanguo Ziqi declare "I effaced myself," thereby holding that one can return to the state of naturalness only after breaking with the "self" that is in opposition to "objects," abandoning his subject-object standpoint and entering a state of "effacement" wherein one fuses with the Dao. Coincidently, the French philosopher Jean Baudrillard also repeatedly stresses the "disappearance of the subject" in his later philosophy, trying to dissolve subject-centrism by means of a counterattack by the object wherein its logic would entrap the subject. Although they lived in different times, both Zhuangzi and Baudrillard note the same human predicament--the situation wherein the "I as subject" constantly obscures the "real I." Their resolutions of the predicament are similar: both put their hopes in the dissolution of the "I" or self in subject-object relations, with Zhuangzi declaring "I effaced myself' and Baudrillard mooting the "disappearance of the subject." They differ, however, on how to dissolve the "I" (myself). Briefly, Zhuangzi advocates "effacing myself through the Dao," that is, quitting one's "fixed mindset" and "egoism" and returning to the Dao by means of "forgetting" or "effacing"; Baudrillard, on the other hand, proposes to "efface oneself through the object," i.e., replace the supremacy of the subject with that of the object. Baudrillard's theory has often been criticized as pataphysics because of its nihilism without transcendence; in contrast, Zhuangzi's view, which construes the whole world as the unfolding of the Dao, seems more thought-provoking. 相似文献
106.
内隐理论是外行人对社会世界中人与事的朴素解释。人们对社会分类(种族、宗教、性别、职业等)属性的理解, 影响着个体对群体信息的加工、判断和反应, 能显著地预测群体过程(如刻板印象、偏见、歧视等), 并调节着社会认同的心理效应, 这弥补了社会认同过程中对个体差异的考虑, 对社会认同理论的发展具有重要贡献。实证研究表明:在改善和促进群体关系的实践中, 可以将外行人的内隐理论作为一个中介, 以此减少刻板印象和偏见, 培育良好的群体关系。未来研究中, 需要进一步整合内隐理论的概念, 采取一些纵向的研究为实践提供科学的指导。 相似文献
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108.
为考察当代中国青少年理想的现状及其影响因素,研究采用当代青少年理想调查问卷对全国12个省份的5000名青少年进行调研,结果发现当代中国青少年的理想水平较高,其中男生在身体理想方面的水平高于女生,在道德、人格、学业、生活和职业等理想方面的水平低于女生;初中生在道德、人格、生活和社会等理想方面的水平高于高中和大学低年级学生,在物质、身体、学业和职业等理想方面的水平低于大学低年级学生,而高中生的学业和职业理想的水平低于初中生和大学低年级学生。回归分析发现,父亲文化程度能够正向预测青少年的职业理想,母亲文化程度对青少年的生活理想有负向预测作用,家庭收入对青少年的物质、生活和身体理想有显著的正向预测作用。 相似文献
109.
模糊决策是特殊、复杂的风险决策, 还是一种独立的决策类型, 是当前认知神经科学争论的热点问题。一系列的fMRI研究分别得出了不同结论, 但大多数证据支持模糊决策和风险决策之间存在分离, 模糊决策有其独特的决策机制; 模糊决策的认知神经机制也是一个亟待解决的问题。因此本研究拟应用事件相关电位技术、生物反馈技术和基因技术, 采用IGT和GDT任务范式, 通过网络成瘾人群和正常人群的对比研究, 去探索模糊决策和风险决策之间的分离; 应用事件相关电位技术和磁共振技术, 采用IGT范式和选瓶任务范式, 研究模糊决策的认知神经机制; 并从临床角度进一步验证上述结果。该项目的开展, 有助于拓广模糊决策的研究领域和视野, 对理解人类在模糊情境下的决策机制以及模糊决策和风险决策之间的关系, 具有重要的理论意义; 对临床上成瘾人群、脑损伤患者的认知诊断和治疗以及现实中企业和个人的决策, 具有重要的参考价值。 相似文献
110.