Strengthening Connections: Functional Connectivity and Brain Plasticity

The ascendancy of functional neuroimaging has facilitated the addition of network-based approaches to the neuropsychologist’s toolbox for evaluating the sequelae of brain insult. In particular, intrinsic functional connectivity (iFC) mapping of resting state fMRI (R-fMRI) data constitutes an ideal approach to measuring macro-scale networks in the human brain. Beyond the value of iFC mapping for charting how the functional topography of the brain is altered by insult and injury, iFC analyses can provide insights into experience-dependent plasticity at the macro level of large-scale functional networks. Such insights are foundational to the design of training and remediation interventions that will best facilitate recovery of function. In this review, we consider what is currently known about the origin and function of iFC in the brain, and how this knowledge is informative in neuropsychological settings. We then summarize studies that have examined experience-driven plasticity of iFC in healthy control participants, and frame these findings in terms of a schema that may aid in the interpretation of results and the generation of hypotheses for rehabilitative studies. Finally, we outline some caveats to the R-fMRI approach, as well as some current developments that are likely to bolster the utility of the iFC paradigm for neuropsychology.     

Adversariality in Argumentation: Shortcomings of Minimal Adversariality and A Possible Reconstruction

Argumentation - Minimal adversariality consists in the opposition of contradictory conclusions in argumentation, and its usual metaphorical expression as a game between combating arguers has seen...     

Diminished heart rate complexity in adolescent girls: a sign of vulnerability to anxiety disorders?

Background and Objectives: Diminished heart rate variability has been found to be associated with high anxiety symptomatology. Since adolescence is the period of onset for many anxiety disorders, this study aimed to determine sex- and anxiety-related differences in heart rate variability and complexity in adolescents.

Methods: We created four groups according to sex and anxiety symptomatology: high-anxiety girls (n?=?24) and boys (n?=?25), and low-anxiety girls (n?=?22) and boys (n?=?24) and recorded their cardiac function while they performed regular school activities. A series of two-way (sex and anxiety) MANOVAs were performed on time domain variability, frequency domain variability, and non-linear complexity.

Results: We obtained no multivariate interaction effects between sex and anxiety, but highly anxious participants had lower heart rate variability than the low-anxiety group. Regarding sex, girls showed lower heart rate variability and complexity than boys.

Conclusions: The results suggest that adolescent girls have a less flexible cardiac system that could be a marker of the girls’ vulnerability to developing anxiety disorders.