Pharmacotherapy of aphasia: myth or reality?

Pharmacotherapy of aphasia had been discussed for the last twenty years with first bromocriptine and amphetamine and then serotoninergic, GABAergic and cholinergic agents. Here, we reviewed the MEDLINE available reports of drug therapy for aphasia. So far, proofs of efficiency were found indubitable for none of the studied molecules. However, some of them showed limited efficiency (piracetam and amphetamine). Moreover, drug therapies for aphasia were less efficient alone than when they were associated with speech therapy.     

Credibility, Idealisation, and Model Building: An Inferential Approach

In this article we defend the inferential view of scientific models and idealisation. Models are seen as “inferential prostheses” (instruments for surrogative reasoning) construed by means of an idealisation-concretisation process, which we essentially understand as a kind of counterfactual deformation procedure (also analysed in inferential terms). The value of scientific representation is understood in terms not only of the success of the inferential outcomes arrived at with its help, but also of the heuristic power of representation and their capacity to correct and improve our models. This provides us with an argument against Sugden’s account of credible models: the likelihood or realisticness (their “credibility”) is not always a good measure of their acceptability. As opposed to “credibility” we propose the notion of “enlightening”, which is the capacity of giving us understanding in the sense of an inferential ability.

---

Habituation of exploratory activity to new stimuli, to the absence of a previously presented stimulus and to new contexts, in rats

Rats trained to run a shuttle-alleyway for food exhibited exploratory behaviour to a novel visual/tactual stimulus presented in a specific place of the alley. Intermittent presentation of the same stimulus in the same place resulted in reduction of the exploratory activity (habituation), both within and between sessions. The animals also directed exploratory activity to the absence of the previously presented stimulus at the place where the stimulus had been presented before; this latter response also habituated. The presentation (1) of the same stimulus to which the animals had already habituated in another place in the alleyway or when the animals were running in an opposite direction to the previous trials of stimulus presentation, or (2) of another stimulus, resulted, again, in the appearance of exploratory activity. These results lead to the conclusion that the animals code external events, store this information, and use it to detect spatial- and directional-contextual changes and to generate predictions about that specific environment.     

Characterizing the Bilingual Disadvantage in Noun Phrase Production

Up to now, evidence on bilingual disadvantages in language production comes from tasks requiring single word retrieval. The present study aimed to assess whether there is a bilingual disadvantage in multiword utterances, and to determine the extent to which such effect is present in onset latencies, articulatory durations, or both. To do so, we tested two groups of Spanish speakers (monolinguals and early highly proficient bilinguals using their first and dominant language) each in two different production tasks: bare noun and noun phrase production. Onset latencies were longer for bilinguals relative to monolinguals in both production tasks. Regarding articulatory durations, we observed a clear bilingual disadvantage in noun phrase production and a strong tendency in bare noun production. These findings generalize the bilingual disadvantage in speech production to various performance measures (onset latency and articulatory duration of production) and beyond single words.     

Large-scale brain systems in ADHD: beyond the prefrontal-striatal model

Attention-deficit/hyperactivity disorder (ADHD) has long been thought to reflect dysfunction of prefrontal-striatal circuitry, with involvement of other circuits largely ignored. Recent advances in systems neuroscience-based approaches to brain dysfunction have facilitated the development of models of ADHD pathophysiology that encompass a number of different large-scale resting-state networks. Here we review progress in delineating large-scale neural systems and illustrate their relevance to ADHD. We relate frontoparietal, dorsal attentional, motor, visual and default networks to the ADHD functional and structural literature. Insights emerging from mapping intrinsic brain connectivity networks provide a potentially mechanistic framework for an understanding of aspects of ADHD such as neuropsychological and behavioral inconsistency, and the possible role of primary visual cortex in attentional dysfunction in the disorder.     

Psychometric properties of the Spanish version of the self-report Personality Diagnostic Questionnaire -4+ (PDQ-4+) in psychiatric outpatients

We examined the psychometric properties of the Spanish version of the self-report Personality Diagnostic Questionnaire-4+ (PDQ-4+) in a sample of 437 psychiatric outpatients. Psychometric properties were assessed through internal consistency analysis, exploratory factor analysis (EFA) and concurrent validity. Results indicate that the Spanish version of the PDQ-4+ has moderate internal consistency, which was acceptable for 7 of the 12 self-report scales. The factor structure roughly replicated the DSM-IV clusters. The presence of Personality Disorders was associated with the character dimensions of the Temperament and Character Inventory (TCI).     

Increased sensitivity to proactive and retroactive interference in amnestic mild cognitive impairment: new insights

Background

Increased sensitivity to proactive (PI) and retroactive (RI) interference has been observed in amnestic mild cognitive impairment (aMCI). PI and RI are often explained as being the result of a response competition mechanism. However, patients with aMCI are supposed to suffer mostly from encoding deficits. We hypothesized that in aMCI interference may occur at encoding and not only at the retrieval stage.

Material and methods

We developed an original paradigm enabling PI and RI to be tested with and without response competitors. Eighteen young controls (YC), 16 elderly controls (EC) and 15 aMCI participated in the study.

Results

The YC and EC groups presented interference effects only in conditions that included a direct response competitor. In contrast, aMCI had interference effects in all conditions including the one without response competitor.

Conclusion

Increased sensitivity to interference in aMCI appears to occur at the encoding/consolidation stage and not only at the retrieval stage, as is the case in healthy subjects. This result is discussed in the context of the associative encoding deficits characterizing aMCI.     

Testing Target Congruence Theory on Emotional Abuse Victimization Experienced by Heterosexual and LGBQ College Students

Criminological theories traditionally used to explain crime and deviance have now been applied to explain physical intimate partner violence (IPV) experienced by heterosexual and LGBQ victims. Notably missing, however, are studies that test theories that explain why individuals may become victims of emotional abuse by sexual orientation. To this end, we applied target congruence theory to examine the influence of target vulnerability, gratifiability, and antagonism on emotional abuse experienced by college students. Data obtained from two public universities (Heterosexuals=366, LGBQ=113) showed partial support for the theory, with target vulnerability consistently predicting emotional abuse victimization regardless of sexual orientation.     

Emotional responses to a negative emotion induction procedure in Borderline Personality Disorder

The aim of this study was to determine if patients with Borderline Personality Disorder (BPD) present higher emotional response than healthy controls in a laboratory setting. Fifty participants (35 patients with BPD and 15 healthy controls) underwent a negative emotion induction procedure (presentation of standardized unpleasant images). Subjective emotional responses were assessed by means of self-reported questionnaires while biological reactivity during the procedure was measured through levels of salivary cortisol (sCORT) and alphaamylase (sAA). Patients with BPD exhibited significant lower cortisol levels and higher sAA levels compared to controls. Self-reported emotional reactivity did not give rise to differences between groups but participants with BPD did present higher levels of negative emotional intensity at baseline and during the entire procedure. The findings do not give support to the emotional hyperreactivity hypothesis in BPD. However, BPD patients presented heightened negative mood intensity at baseline, which should be considered a hallmark of the disorder. Further studies using more BPD-specific emotion inductions are needed to confirm the trends observed in this study.