基于CiteSpace近10年中医药科技伦理研究知识图谱分析

追踪和探索近10年中医药科技伦理研究的趋势与热点。检索中国知网数据库近10年相关文献,应用CiteSpace 6.1.R6软件分别对纳入的238篇文献的作者、机构、关键词绘制知识图谱并进行分析。从2013年1月1日—2023年1月1日,中医药科技伦理领域发文量总体呈波动性上升趋势。频数最多的5个关键词为伦理审查、中医药、临床研究、中医、伦理。研究显示中医药研究伦理审查、中医药现代化面临的伦理问题、中医学理论在伦理领域的新发展、中国传统医德研究是该领域关注的重点。大医精诚的相关研究可能成为未来研究方向。

     

Borderline psychopathology in the first-degree relatives of borderline and axis II comparison probands

The purpose of this study was to assess the prevalence of each of the nine DSM criteria for borderline personality disorder and the prevalence of the disorder itself in the first-degree relatives of borderline probands and Axis II comparison subjects. Four hundred and forty-five inpatients were interviewed about familial borderline psychopathology using the Revised Family History Questionnaire--a semistructured interview of demonstrated reliability. Of these 445 subjects, 341 met both DIB-R and DSM-III-R criteria for BPD and 104 met DSM-III-R criteria for another type of personality disorder (and neither criteria set for BPD). The psychopathology of 1,580 first-degree relatives of borderline probands and 472 relatives of Axis II comparison subjects was assessed. Both DSM-III-R and DSM-IV BPD were found to be more common among the relatives of borderline than Axis II comparison probands. However, five of the criteria for BPD (inappropriate anger, affective instability, paranoia/dissociation, general impulsivity, and intense, unstable relationships) and all four sectors of borderline psychopathology (affect, cognition, impulsivity, and interpersonal relationships) were found to be both more common and discriminating than the BPD diagnosis itself. Taken together, the results of this study suggest that the subsyndromal phenomenology of BPD may be more common than the borderline diagnosis itself.     

Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice

We previously reported that a total methanolic extract of the underground part of Angelica gigas Nakai (Umbelliferae) (here-in-after abbreviated AG) significantly inhibited acetylcholinesterase (AChE) activity. We characterized 12 coumarin derivatives including both decursin and decursinol from extracts of AG. In this study, we evaluated the anti-amnestic activity of decursin, a major coumarin constituent isolated from AG, in vivo using ICR mice with amnesia induced by scopolamine (1 mg/kg body weight, s.c.). Decursin, when administered to mice at 1 and 5 mg/kg body weight i.p., significantly ameliorated scopolamine-induced amnesia as measured in both the passive avoidance test and the Morris water maze test. Moreover, decursin significantly inhibited AChE activity by 34% in the hippocampus of treated mice. These results indicate that decursin may exert anti-amnestic activity in vivo through inhibition of AChE activity in the hippocampus.     

Religious goodness and political rightness: Toward a reflective equilibrium beyond liberalism and communitarianism

International Journal for Philosophy of Religion -     

基于文化的心理复原力研究

随着对个体心理复原力研究不断深入,文化作为影响个体心理复原力的重要因素日益受到关注,研究者在厘清文化与复原力之间的关系后,尝试以积极心理学的视角,将中国传统文化中"天人合一"、"以人为本"、"自强不息"、"厚德载物"等文化精神引入到个体心理复原力发展的过程中,为个体心理复原力的研究贡献价值。     

Stress induces glucocorticoid-mediated apoptosis of rat Leydig cells in vivo

Stress can disrupt endocrine signalling in the male reproductive axis through high concentrations of glucocorticoids, the hallmark of stress. Our previous work revealed that a stress level of exogenous glucocorticoids could induce apoptosis of rat Leydig cells, which are the primary source of testosterone. The aim of this study was to investigate whether stress can induce apoptosis in rat Leydig cells in vivo and, if so, whether the process is the result of a direct effect of glucocorticoids. In a chronically stressed rat model, serum corticosterone concentration was increased significantly whereas serum testosterone was decreased. The frequency of apoptotic Leydig cells in stressed rats was also increased. Adrenalectomised rats subjected to chronic stress showed an elevated serum testosterone, while the apoptotic frequency of Leydig cells was not increased. It was established that glucocorticoid-induced Leydig cell apoptosis is mediated by glucocorticoid receptors (GRs), which translocate from cytoplasm to nucleus. Adenovirus microRNA-induced downregulation of GR expression in vitro alleviated the corticosterone-induced increase in apoptosis of Leydig cells. These results indicate that the stress-induced increase in corticosterone secretion resulted in apoptosis in rat Leydig cells in vivo, and thereby decreased testosterone synthesis.     

An Analysis on the Research Ethics Cases Managed by the Committee on Publication Ethics (COPE) Between 1997 and 2010

The growing emphasis on the importance of publishing scientific findings in the academic world has led to increasing prevalence of potentially significant publications in which scientific and ethical rigour may be questioned. This has not only hindered research progress, but also eroded public trust in all scientific advances. In view of the increasing concern and the complexity of research misconduct, the Committee on Publication Ethics (COPE) was established in 1997 to manage cases with ethical implications. In order to review the outcomes of cases investigated by COPE, a total of 408 cases that had been managed by COPE were successfully extracted and analysed with respect to 7 distinct criteria. The results obtained indicate that the number of ethical implications per case has not changed significantly (p?>?0.01) since the year COPE was instigated. Interestingly, the number of ethical cases, and to some extent, research misconduct, is not diminishing. Therefore, journal editors and publishers need to work closely together with COPE to inculcate adoption of appropriate research ethics and values in younger researchers while discouraging others from lowering standards. It is hoped that with a more concerted effort from the academic community and better public awareness, there will be fewer incidences of ethically and scientifically challenged publications. The ultimate aim being to enhance the quality of published works with concomittant public trust in the results.     

Gelotophobia and thinking styles in Sternberg's theory'

A hypothesis was examined, that gelotophobia (the fear of being laughed at) was negatively related to Type I thinking styles and positively related to Type II thinking styles as defined in Sternberg's theory of mental self-government. 431 university students (250 women, 181 men; M age = 20.4 yr., SD = 1.2) completed self-report measures of gelotophobia (GELOPH <15>) and thinking styles (Thinking Styles Inventory-Revised). Correlation and regression analyses were conducted. The results indicated that gelotophobia was negatively and significantly related to four Type I thinking styles (legislative, judicial, liberal, and hierarchical thinking styles) and a Type III thinking style (external), while it was positively and significantly related to a Type II thinking style (conservative). Thinking styles uniquely explained 18% of the total variance in gelotophobia scores. Possible interventions from the perspective of thinking styles in the treatment of gelotophobia were discussed.     

小学低年级汉语儿童语素意识、汉字识别和词汇知识的发展关系——交叉滞后研究

以146名小学一年级儿童为研究对象, 进行了历时2年的3次追踪测试, 考察小学生从一到三年级的语素意识、汉字识别和词汇知识之间发展关系的变化。在控制了语音意识、快速命名、正字法意识、一般认知能力和自回归效应后, 结果发现：(1)一年级时的汉字识别显著预测二年级的同音语素意识和同形语素意识; (2)一年级时的词汇知识显著预测二年级的复合语素意识和汉字识别; (3)二年级时的汉字识别和词汇知识对三年级的同音语素意识、同形语素意识和复合语素意识均有显著预测作用; (4)二年级时的同形语素意识对三年级的词汇知识具有显著预测作用。结果表明, 小学一至三年级的汉字识别和词汇知识对语素意识具有预测作用; 三种语素意识对汉字识别和词汇知识的预测作用中, 只有同形语素意识能够显著预测词汇知识; 三种语素意识、汉字识别和词汇知识的发展关系存在变化且具有阶段性特点。     

新世纪20年国内假设检验及其关联问题的方法学研究

新世纪20年来国内假设检验方法学研究内容可分为如下几类: 零假设显著性检验的不足、p值的使用问题、心理学研究的可重复性问题、效应量、检验力、等效性检验、其他与假设检验关联的研究。零假设显著性检验已经发展成一套组合流程: 为了保证检验力和节省成本, 实验研究需要做先验检验力分析预估样本容量, 但问卷超过160人在传统统计中就没有必要这样做。当拒绝零假设时, 应当结合效应量做出结论。当不拒绝零假设时, 需要报告后验检验力; 如果效应量中或大而检验力不够高, 则可增加被试再行分析, 但这一过程应主动披露, 报告最后的实际p值并对可能犯的第一类错误率做出评估。