Association of <Emphasis Type="Italic">ADAM10</Emphasis> and <Emphasis Type="Italic">CAMK2A</Emphasis> Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p < 10⁻³), nine of which were located in known genes, including ADAM10 (rs383902, p = 0.00036) and CAMK2A (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer’s disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.     

Governing drug use through neurobiological subject construction: The sad loss of the sociocultural

Based on their "drugs as instruments" framework, Müller & Schumann (M&S) propose a staged drug policy that matches well the neoliberal governance scheme. To mend the sad loss of the sociocultural dimension in their model, I propose three such considerations: first, sociocultural interactions with the brain; second, sociocultural context and justice of drug use; and third, sociocultural preparedness for implementing their drug policy.     

Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse

The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse. Twenty one patients with NMO and 21 normal control subjects received several cognitive tests to assess cognitive function. Head diffusion tensor imaging (DTI) of all patients with NMO were collected with a 3-T MR system. Correlations of cognitive test scores and whole brain FA and MD were examined by voxel-based analysis. Region-of-interest analysis was applied to the significantly correlated regions which the most frequently appeared. We found that NMO patients without visible brain lesions had significantly impaired learning and memory, decreased information processing speed, and damaged attention compared with normal control subjects. These impaired cognitive domains were significantly correlated with FA and MD in local regions of corpus callosum, anterior cingulate and medial frontal cortex. In corpus callosum of NMO patients, mean FA was significantly lower and mean MD higher than normal control subjects. Our findings suggest that cognitive impairments in learning and memory, information processing speed and attention occur in NMO patients without visible brain lesions during acute relapse. The impairments in immediate and short-term memory in NMO patients may be due to information encoding deficits in the process of information acquisition. The corpus callosum of such patients may have local microscopic damages that play a role in cognitive impairments during acute relapse.     

Parental Psychological Control and Adolescents’ Problematic Mobile Phone Use: The Serial Mediation of Basic Psychological Need Experiences and Negative Affect

Journal of Child and Family Studies - Drawing on self-determination theory and problem-behavior theory, we tested the relation between parental psychological control and adolescents’...     

先前知识经验对远距离水平映射规则内隐学习的限制

先前研究发现远距离规则能够被内隐地习得和迁移,表明内隐学习获得的知识是底层的抽象规则,那么这一抽象规则的习得和迁移是否会受到先前知识经验的限制?研究采用汉语声调的远距离水平映射规则为材料,通过创设不符合平仄知识经验的任意声调水平映射规则,在控制组块和重复结构等表面特征的条件下,探讨先前知识经验是否限制了远距离水平映射规则的内隐学习和迁移。结果发现相对于符合平仄知识经验的汉语声调水平映射规则,被试不能够内隐地习得和迁移任意声调的水平映射规则,表明先前知识经验在远距离水平映射规则内隐学习过程中发挥着重要作用。     

The Sex-Based Harassment Inventory: A Gender Status Threat Measure of Sex-Based Harassment Intentions

Sex Roles - We introduce a new inventory measuring sex-based harassment intentions and threat perceptions grounded in gender status threat theories (Berdahl, 2007; Stephan et al., 2016). In Study 1...     

Mental Disorders Associated with COVID-19 Related Unemployment

In response to the COVID-19 pandemic, restrictions on economic activities have resulted in a sharp rise of unemployment. The purpose of this research is to explore mental disorders associated with COVID-19 related unemployment using a large, nationally representative dataset, the 2020 COVID-19 Household Pulse Survey. ANOVA with post hoc tests (Tukey HSD) are utilized to reveal the mean difference of mental disorders between various employment status, as well as between reasons of unemployment. Binary logit model is used to investigate the potential effect of different reasons of unemployment on mental disorders. Individuals who were not working during the pandemic due to involuntary reasons had higher probabilities of mental disorders than those who were working and those who voluntarily separated from work. Among respondents who were not working due to COVID-19 related reasons, respondents whose employer went out of business were the most likely to experience mental disorders. Household job uncertainty in the next four weeks positively contributed to mental disorders. Government should consider measures to contain the spread of virous while keeping as many people employed as possible. Government should also consider providing adequate financial and counseling assistance to individuals who are in the greatest need for such support.

     

Correction to: Trends of Positive Youth Development Publications (1995–2020): A Scientometric Review

Applied Research in Quality of Life - A Correction to this paper has been published: https://doi.org/10.1007/s11482-020-09905-3     

多级评分模型下的题库结构对CAT的影响分析

在多级评分模型下,项目的难度参数或步骤参数有多个,在对多级评分模型进行选题时,通常对项目的多个难度参数用一个综合的指标来概括.当对每个项目的难度参数进行有效的综合后,综合后的难度参数分布发生了改变,这时如果增加适量的平均难度较难或较易的项目进入题库,测验的精度和项目的曝光率都有一定的改善.     

记忆集对注意焦点转换及其返回抑制的影响

采用记忆更新任务,实验1要求被试分别更新3个和4个记忆项目,并设置不转换、控制转换和抑制转换条件,考察记忆集对注意焦点转换及其返回抑制的影响;实验2操纵两次更新同一记忆项目之间对其它记忆项目更新的次数（2次、3次及3次以上）,在实验1基础上,考察返回抑制中项目抑制状态的消退过程.结论：随记忆集增加,转换代价增大,而返回抑制效应消失;当注意焦点对其它记忆项目更新2次时,之前被抑制项目的抑制状态可完全消退.