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91.
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment 总被引:1,自引:0,他引:1 下载免费PDF全文
Shum FW Wu LJ Zhao MG Toyoda H Xu H Ren M Pinaud R Ko SW Lee YS Kaang BK Zhuo M 《Learning & memory (Cold Spring Harbor, N.Y.)》2007,14(4):304-312
Exposure to an enriched environment (EE) has been shown to induce cortical plasticity. Considerable amount of research is focused on the effects of EE in the hippocampus; however, effects of EE on other brain regions and the mechanisms involved are not well known. To investigate this, we induced cortical plasticity by placing mice in an EE for one month and measured the effects of EE in the anterior cingulate cortex (ACC). Here, we show that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulate long-term potentiation (LTP) and decreased cingulate long-term depression (LTD). The increased NMDA receptor NR2B/NR2A subunits current ratio is associated with the plasticity seen in the ACC while total protein levels remain unchanged. Furthermore, behavioral experiments show that these mice exposed to EE demonstrate enhanced responses to acute and long-term inflammation. Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation. 相似文献
92.
现代性在将自我推至无以复加程度的同时,也对自我作了片面化处理,自我成为了不依赖自然、社会和他者而独立存在的东西,进而丧失了外在的禁忌,成为自我占有、欲望至上的存在者。在无限的消费和无尽的欲望的满足过程中,自我所获得的只是一种暂时的、粗鄙的、狭隘的满足。被欲望驱使的现代人应该实现欲望的合理化,激发神圣感,提高自身的生存境界,以便在资本逻辑推动下的骚动不安的世界中寻求心灵上的宁静和思绪上的久远。 相似文献
93.
Models of human gait are based on adult locomotion. C. E. Bauby and A. D. Kuo (2000) proposed that adults rely on passive mechanisms at the spinal level to control motion in the anteroposterior direction and rely on direct monitoring of postural control in the lateral direction. The authors' purpose in this study was to determine if that model applies to control at the onset of walking in typically developing toddlers (n = 9) and in toddlers with Down syndrome (n = 6). Their longitudinal data suggested that toddlers control gait in a distinctly different manner than adults do. An adult pattern of control emerges with experience. In addition, the effect of experience on the emergence of that pattern is magnified by task-specific early intervention. The present data support the emergence and discovery of efficient patterns of control in this fundamental human behavior. 相似文献
94.
This study evaluated the effects of the mode of grasping, chopstick materials, and the groove of the chopstick-tip on gripping performance of 32 participants, among whom 16 were accustomed to using chopsticks with a pliers-grasping mode and the other 16 with a scissors-grasping mode. Based on a random sequence, 8 kinds of chopsticks with different combinations (materials: bamboo, wood, plastic, and stainless steel, with and without grooves in the chopstick-tip) were used to carry out the action of gripping two different objects (peanuts and longan). The time to finish gripping 50 pieces of peanut and longan, the number which fell on the table when gripping, the subjective effort and the subjective preference were measures of efficiency of pinching for 8 kinds of chopsticks. Analysis showed that chopstick materials significantly affect time of gripping. The large object (such as longan) could be gripped more easily with the pliers-grasping mode or gripped with the grooved chopstick-tip. However, for small objects (such as peanuts), there was no significant difference in performance whether the chopstick-tip was grooved or not. A combination of bamboo chopsticks with grooved tips used with a pliers-grasping seem preferrable for more favorable gripping performance. 相似文献
95.
In an experiment with 80 participants in China, protagonists with opposing views in organizations that valued collectivism, compared to individualism, were found to develop cooperative goals, were confident that they could work, sought to understand, and demonstrated that they understood the opposing arguments, accepted these arguments as reasonable, and combined positions to create an integrated decision. The inductions comparing participants who valued harmony as a goal or a technique in which they pretended to agree were only partially effective and did not yield significant differences on conflict dynamics and outcomes. Findings challenge traditional theorizing that collectivistic values lead to conflict avoidance, and support recent arguments that strong, cooperative relationships promote the productive discussion of opposing views in decision making. 相似文献
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神经性厌食症和神经性贪食症是主要的进食障碍症状。进食障碍的影响因素有社会文化因素(例如媒体和同伴的影响)、家庭因素(如困惑和冲突)、消极情绪、低自尊水平和对自身的不满及认知和生物方面的因素等。 相似文献
99.
Self-esteem is a positive evaluation of oneself that can facilitate optimal functioning. However, little research has focused on its antecedents in sport. Accordingly, we adopted an interactionism perspective and proposed that gratitude, a dispositional factor, will enhance an athlete's self-esteem and affective trust in coach, a situational factor, will strengthen such a positive effect. Athletes completed measures of gratitude, affective trust in coach, and self-esteem at Time 1 and self-esteem at Time 2 after 6 months. Results showed that athletes with higher levels of gratitude increased their self-esteem over time when they had higher affective trust in their coaches. 相似文献
100.
Weiping Hu Baojun Wu Xiaojuan Jia Xinfa Yi Chunyan Duan Winter Meyer James C. Kaufman 《创造性行为杂志》2013,47(1):3-21
The “Learn to Think” (LTT) Intervention Program was developed for raising thinking abilities of primary and secondary school students. It has been implemented in more than 300 schools, and more than 200,000 students took part in the experiment over a 10‐year span. Several longitudinal intervention studies showed that LTT could promote the development of students' thinking ability, learning motivation, and learning strategy as well as raise academic performance in primary schools. This article describes a study of the influence and the delayed effects of LTT on the scientific creativity of secondary school students. One hundred and seven students were selected from a secondary school, 54 of them participated in the LTT every 2 weeks and the rest had not. The intervention lasted 2 years, and the delayed effect was explored half a year after terminating the intervention. The Scientific Creativity Test for Secondary School Students was used four times from pre‐test to delayed post‐test. The results indicated that the LTT did promote the development of scientific creativity of secondary school students, and the effects on the scientific creativity were not necessarily immediate, but tended to be long‐lasting. 相似文献