材料情绪性对条件推理影响的眼动研究

以大学生为被试,采用不同情绪效价的条件命题作为实验材料,运用眼动仪器记录被试进行条件推理的过程和结果,探讨了材料情绪性对条件推理的影响状况.实验采用3(材料情绪性:正性情绪、负性情绪、中性情绪)×4(推理形式:MP、DA、AC、MT)的重复测量实验设计.研究结果发现,正性和负性情绪材料的条件推理成绩显著地低于中性情绪材料,结果支持抑制假说.     

青少年攻击行为与友谊质量的交叉滞后回归分析

该研究采用问卷法,对湖北省一所初级中学二年级青少年进行了一个学年的纵向追踪研究,使用Bjorkquist等人编制的直接和间接攻击量表(DIA)以及Parker和Asher编制的友谊质量问卷(FQQ)测查青少年的身体攻击和友谊质量。然后采用二元交叉滞后回归分析法考察了初中二、三年级学生在一个学年中的攻击行为与友谊质量(总问卷及分问卷得分)的关系。结果表明,在控制了前测"肯定与关心"得分后,身体攻击显著地负向预测了"肯定与关心"得分。在控制了前测的"冲突解决策略"得分后,攻击行为边缘显著地预测了后测的"冲突解决策略"得分。同时发现,后测"身体攻击"和"冲突与背叛"不存在显著的相关。     

伊斯兰教与世俗化问题再思考

宗教作为一种社会存在、社会文化形态,它与人类社会是双向互动的。社会生活世俗化与社会宗教道德规范化、制度化,在任何人类社会都是互有联系和区别的现象。本文以伊斯兰教历史上三个有代表性的时间节点为线索,就其与世俗化的关系问题进行了一些学理上的梳理。     

Active coping with stress suppresses glucose metabolism in the rat hypothalamus

We used 18F-fluorodeoxyglucose small-animal positron-emission tomography to determine whether different styles of coping with stress are associated with different patterns of neuronal activity in the hypothalamus. Adult rats were subjected to immobilization (IMO)-stress or to a non-immobilized condition for 30 min, in random order on separate days, each of which was followed by brain-scanning. Some rats in the immobilized condition were allowed to actively cope with the stress by chewing a wooden stick during IMO, while the other immobilized rats were given nothing to chew on. Voxel-based statistical analysis of the brain imaging data shows that chewing counteracted the stress-induced increased glucose uptake in the hypothalamus to the level of the non-immobilized condition. Region-of-interest analysis of the glucose uptake values further showed that chewing significantly suppressed stress-induced increased glucose uptake in the paraventricular hypothalamic nucleus and the anterior hypothalamic area but not in the lateral hypothalamus. Together with the finding that the mean plasma corticosterone concentration at the termination of the IMO was also significantly suppressed when rats had an opportunity to chew a wooden stick, our results showed that active coping by chewing inhibited the activation of the hypothalamic-pituitary-adrenal axis to reduce the endocrine stress response.     

Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice

It is established that stress impairs spatial learning and memory via the hypothalamus-pituitary-adrenal axis response. Dopamine D1 receptors were also shown to be responsible for a stress-induced deficit of working memory. However, whether stress affects the subsequent emotional learning and memory is not elucidated yet. Here, we employed the well-established one-trial step-through task to study the effect of an acute psychological stress (induced by tail hanging for 5, 10, or 20?min) on emotional learning and memory, and the possible mechanisms as well. We demonstrated that tail hanging induced an obvious stress response. Either an acute tail-hanging stress or a single dose of intraperitoneally injected dopamine D1 receptor antagonist (SCH23390) significantly decreased the step-through latency in the one-trial step-through task. However, SCH23390 prevented the acute tail-hanging stress-induced decrease in the step-through latency. In addition, the effects of tail-hanging stress and/or SCH23390 on the changes in step-through latency were not through non-memory factors such as nociceptive perception and motor function. Our data indicate that the hyperactivation of dopamine D1 receptors mediated the stress-induced deficit of emotional learning and memory. This study may have clinical significance given that psychological stress is considered to play a role in susceptibility to some mental diseases such as depression and post-traumatic stress disorder.     

Bioethics committee in the university teaching hospital in Bordeaux

Set up in 2011, the ethics committee at the teaching hospital in Bordeaux, although it is now obsolete in its organisation because of the "standardisation" in early 2012 of regional ethics groups, was nevertheless an original structure which deserves to be analysed for several reasons. First of all, why have a hospital ethics committee? Then, to do what? Finally, it is interesting to give a few indications about the working of this committee.     

The impact of development of population-based study in the biomedical field on laws and regulations: a cross-strait experience on biobank development

Together with the completion of the Human Genome Project, biomedical research has marched into the "Post-Genomic Era." In order to take advantage of this extracted gene related information extensively and precisely so as to realize man's biological phenomena as well as the mechanism of pathogenesis, consequentially, a large scale sample collection of different geological areas and/or ethnic groups becomes necessary for the future population based genetic research of a country and, in turn, the construction of population-based genetic database (Biobank). In recent years, both mainland China and Taiwan have not only made great progress in information and computation technologies, but have also gradually taken a close look into the quality of medicine delivery. Thus, it becomes unavoidable for both sides to create each one's population-based genetic databases (Biobank). Theoretically speaking, the Biobank development shall benefit the study on the correlation between genes and disease and also the solution for disease treatment as well. At the same time, medical diagnostic technology has also been significantly improved. It is believable that the population-based genetic database might be utilized to promote medical quality and to reduce the cost of public health delivery. Further; in the near future, it might become the "raw materials "for medical research application. However when taking promotion of public welfare as the premises for a Biobank development, the severe and multi challenge occurred against the traditional legal rules in terms of the privacy protection, public trust development, the compliance of informed consent principle, the implementation of benefit-sharing doctrine and the possible discrimination concern about the population/participants selection and some other ELSI issues. In this paper, the major legal issues encountered by the Biobank development will first be reviewed accompanied by the background information concerning the Biobank development scenario crossing the Taiwan Strait. Also, mainly following the realm of comparative policy or legal approaches, the paper learning from the fruits of this comparative study, tries to propose some recommendations for future legislative consideration by both mainland China and Taiwan. It's been this author's wish that, when establishing a large scale population based Biobank, the promotion of public trust shall be placed as the primary goal together with the emphasis on supporting publicity and transparency on the administrative practices, so as to encourage the public participation in observing the principle of altruism and, in turn, benefit the future biomedicine development.