The role of regional heterogeneity in age-related differences in functional hemispheric asymmetry: an fMRI study

Neuroimaging literature has documented age-related hemispheric asymmetry reduction in frontal regions during task performances. As most studies employed working memory paradigms, it is therefore less clear if this pattern of neural reorganization is constrained by working memory processes or it would also emerge in other cognitive domains which are predominantly lateralized. Using blocked functional magnetic resonance imaging (fMRI), the present study used a homophone judgment task and a line judgment task to investigate age-related differences in functional hemispheric asymmetry in language and visuospatial processing respectively. Young and older adults achieved similar task accuracy although older adults required a significantly longer time. Age-related functional hemispheric asymmetry reduction was found only in dorsal inferior frontal gyrus and was associated with better performance when the homophone condition was contrasted against fixation, and not line condition. Our data thus highlights the importance of considering regional heterogeneity of aging effects together with general age-related cognitive processes.     

Dorsomedial prefrontal cortex 5-HT6 receptors regulate anxiety-like behavior

The dorsomedial prefrontal cortex (dmPFC) plays a very important role in decision-related and anxiety-related information processing. It has enriched 5-HT6 receptors; however, the precise role of dmPFC 5-HT6 receptors in anxiety remains to be fully investigated. In this study, we injected dmPFC with the 5-HT6 receptor agonist EMD 386088 and antagonist SB 271046 using stereotactic technology. 5-HT6 receptor activation in mice increased time spent in the center area on the open-field test, increased exploration of the open arms on the elevated plus maze test, and increased ratio on the social interaction test. 5-HT6 receptor inactivation induced the opposite effects. In brain slices, EMD 386088 decreased both spontaneous inhibitory postsynaptic currents (sIPSC) and spontaneous excitatory postsynaptic currents (sEPSC), while SB 271046 only increased sEPSC. These effects of EMD 386088 and SB 271046 could be reversed by the GABA_A receptor antagonist bicuculline (BMI) and positive allosteric modulator clonazepam (CLZ), respectively. Our results suggest that neurotransmission in the dmPFC by 5-HT6 receptor activation and inhibition may play an important role in anxiety-like behavior, and may provide new insight into the pathological mechanism and potential target of anxiety disorders.     

The role of the oath in credibility assessment

Based on the adaptive lie detector theory, this study is an examination of whether taking an oath, as context‐general information, increases the credibility of a suspect. The consistency of the testimonies of 6 eyewitnesses was manipulated so that it could be used as individuating information. There were 2 sets of testimonies: one that was consistent and one that was inconsistent. The results supported the adaptive lie detector theory. The participants judged those persons who took an oath to be more credible than those who did not, but this only happened in situations where the testimonies of the eyewitnesses were inconsistent. The theoretical and practical implications of the findings and future directions are then discussed.     

Emotionally conditioning the target-speech voice enhances recognition of the target speech under “cocktail-party” listening conditions

Under a noisy “cocktail-party” listening condition with multiple people talking, listeners can use various perceptual/cognitive unmasking cues to improve recognition of the target speech against informational speech-on-speech masking. One potential unmasking cue is the emotion expressed in a speech voice, by means of certain acoustical features. However, it was unclear whether emotionally conditioning a target-speech voice that has none of the typical acoustical features of emotions (i.e., an emotionally neutral voice) can be used by listeners for enhancing target-speech recognition under speech-on-speech masking conditions. In this study we examined the recognition of target speech against a two-talker speech masker both before and after the emotionally neutral target voice was paired with a loud female screaming sound that has a marked negative emotional valence. The results showed that recognition of the target speech (especially the first keyword in a target sentence) was significantly improved by emotionally conditioning the target speaker’s voice. Moreover, the emotional unmasking effect was independent of the unmasking effect of the perceived spatial separation between the target speech and the masker. Also, (skin conductance) electrodermal responses became stronger after emotional learning when the target speech and masker were perceptually co-located, suggesting an increase of listening efforts when the target speech was informationally masked. These results indicate that emotionally conditioning the target speaker’s voice does not change the acoustical parameters of the target-speech stimuli, but the emotionally conditioned vocal features can be used as cues for unmasking target speech.     

高道蹇拱辰的修炼思想及其对苏轼的影响

北宋神宗时期,四川成都出现了一位高道蹇拱辰。他因悟人生之虚幻,离家远游各地,居庐山修道,期间又到京师,与苏轼、苏辙、秦观、贺铸、李龙眠等名士交往。在内丹修炼尚未盛行之际,蹇拱辰结合《黄庭经》,创立了     

元伦理学家认为不能从“是”推出“应该”吗

摩尔所谓"自然主义谬误"批判的是将"善"这种非自然的属性直接等同于快乐、进化以及实存等这些非价值属性的自然物,但他并不否认可以从这些具体的善事物或手段善中推导出善本身;斯蒂文森的温和情感主义虽然强调态度分歧对于信念分析的根本性和相对独立性,但并不否认部分态度分歧对于信念分歧的依赖性和共存性;黑尔作为元伦理学向规范伦理学复归的一个重要代表,更是有意弥合事实与价值的裂痕,强调道德语言的普遍规定性,强调作为社会事实的社会制度对价值评价的决定性和基础性作用。因此,通常所认为的元伦理学关于不能从"是"推出"应该"的结论,实际上是对元伦理学观点的误读,而这种误读也同样发生在休谟身上。     

Trajectories of Postpartum Maternal Depressive Symptoms and Children’s Social Skills

The vast majority of new mothers experience at least some depressive symptoms. Postpartum maternal depressive symptoms can greatly influence children’s outcomes (e.g., emotional, cognitive, language, and social development). However, there have been relatively few longitudinal studies of how maternal depressive symptoms may influence children’s social skills. The current study (n = 1363) examined the trajectory of maternal depressive symptoms (from 1 month to 36 months) and whether maternal depressive symptoms at 1 month postpartum and the change in symptoms over time (from 1 month to 3 years) predicted children’s parent- and teacher-rated social skills when they were 4.5 and 6.0 years old. A growth curve model indicated that, on average, maternal depressive symptoms declined over time in a nonlinear fashion. Further analyses indicated that after controlling for five demographic factors (child sex, family income, maternal age, mother’s marital status, and maternal education), initial maternal depressive symptoms significantly predicted children’s social skills as reported by mothers. The results support the notion that maternal depressive symptoms during children’s infancy can have long-term associations with children’s social skills. In addition, the results emphasize the importance of intervention and prevention efforts targeting maternal depressive symptoms during infancy, beginning immediately postpartum.     

Maternal Depressive Symptoms When Caring for a Child with Mental Health Problems

As primary caregivers of children with mental health problems, mothers face challenges that put them at risk for depression, which is rarely identified or addressed. The aims of this paper were to (a) identify mean differences among demographic, stressor, threat, and resource variables specified in a theoretical model and thought to be associated with maternal depressive symptoms and (b) determine how much variability in depressive symptoms is explained by these variables. High levels and prevalence of depressive symptoms were found within a quality of life study that these data were drawn from. Of 139 mothers participating in this study, 58% had a score of 16 or greater on the CES-D indicating moderate to high levels of depressive symptoms. Significant differences were found between mothers with higher versus lower levels of depressive symptoms for 11 of the 18 variables. Hierarchical regression was used to examine the variance explained in depressive symptoms based upon the conceptual model with 4 composite variables. Income (step 1), behavioral problems (step 2), threat appraisal (step 3), and resource appraisal (step 4) combined explained 42% of the variance.     

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways.     

Emotional reactions to scandals: When does moral character make a difference?

A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality.