Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice

Cognitive functions usually involve various synaptic proteins and neurotrophic factors in the hippocampus. However, whether treadmill exercise can improve learning and memory by upregulating some of these molecules remain unraveled. To address this question, male BALB/c mice were divided into control and exercise groups, the latter group went through 4 weeks of treadmill exercise training. At the end of exercise training period, they were either tested for passive avoidance (PA) performance or sacrificed for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca²⁺-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic vesicular fusion protein). Our results showed that treadmill exercise training (1) increased the retention latency without affecting the fear acquisition in the PA test, (2) transiently increased the hippocampal BDNF level at 1, 2, and 4 h after the completion of exercise training, and (3) persistently increased the hippocampal protein levels of full-length TrkB, phosphorylated TrkB and synaptotagmin, but not truncated TrkB or SNAP-25. Moreover, the protein expression level of full-length TrkB or synaptotagmin was positively correlated with PA performance in mice. Finally, inhibition of TrkB signaling by K252a abolished the exercise-facilitated PA performance and upregulation of TrkB and synaptotagmin. Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory.     

Acute ethanol ingestion impairs appetitive olfactory learning and odor discrimination in the honey bee

Invertebrates are valuable models for increasing our understanding of the effects of ethanol on the nervous system, but most studies on invertebrates and ethanol have focused on the effects of ethanol on locomotor behavior. In this work we investigate the influence of an acute dose of ethanol on appetitive olfactory learning in the honey bee (Apis mellifera), a model system for learning and memory. Adult worker honey bees were fed a range of doses (2.5%, 5%, 10%, or 25%) of ethanol and then conditioned to associate an odor with a sucrose reward using either a simple or differential conditioning paradigm. Consumption of ethanol before conditioning significantly reduced both the rate of acquisition and the asymptotic strength of the association. Honey bees also exhibited a dose dependent reduction in arousal/attention during conditioning. Consumption of ethanol after conditioning did not affect recall 24h later. The observed deficits in acquisition were not due to the affect of ethanol on gustatory sensitivity or motor function. However, honey bees given higher doses of ethanol had difficulty discriminating amongst different odors suggesting that ethanol consumption influences olfactory processing. Taken together, these results demonstrate that an acute dose of ethanol affects appetitive learning and olfactory perception in the honey bee.     

An examination of the wording effect in the Rosenberg Self-Esteem Scale among culturally Chinese people

Previous psychometric studies of the Rosenberg Self-Esteem Scale (RSES; 1965) have shown that items with positive and negative words tend to form 2 factors instead of a single factor for global self-esteem. Recent studies using confirmatory factor analysis have indicated that there is an additional method effect behind negatively worded items. However, researchers conducted these studies using Western participants. Because J. L. Farh and B. S. Cheng (1997) suggested that culturally Chinese people tend to exhibit a modesty bias in self-evaluation, especially on positively worded items, researchers may infer that a wording effect of positively worded items would be evident for culturally Chinese people. The author examined the wording effect in the RSES for culturally Chinese people by comparing different confirmatory factor models. The author analyzed data from 2 independent samples of students at the National Taiwan University (ns = 393, 441) and a national sample of juniors recruited from 140 universities and colleges in Taiwan in 2004 (n = 28,862). Results showed that in addition to a global factor for self-esteem, method effects of positively and negatively worded items should also be specified for a model fitting culturally Chinese people.     

聋童执行功能发展：聋童与正常儿童的比较

利用标准Dimensional Change Card Sort任务(DCCS),对76名智力正常的3~8岁聋童和78名3~5.5岁的正常儿童进行了对比测试,旨在考察聋童执行功能发展的年龄特征与发展水平。结果发现,3岁组的聋童和正常儿童在DCCS任务上的表现没有显著性差异,但正常儿童在4~4.5岁时进入一个迅速发展期,而聋童要在6岁时才有快速的发展,到7岁后才相当于正常儿童5岁的发展水平,大约滞后2年。研究认为,造成聋童执行功能发展滞后的原因主要有：（1）语言符号系统和聋童特有的符号系统之间可能存在的差异;（2）聋童可能存在计划和灵活性的缺陷;（3）聋童可能存在命名和标识策略上的困难和注意机制的缺陷。结合关于聋童心理理论发展滞后于正常儿童7年以上的报道,心理理论发展和执行功能发展在聋童身上表现出较大的不一致性。     

计数与匹配:5~6岁儿童量比较策略的发展特点

选取56名5~6岁儿童,采用计算机呈现刺激的方式,实现了刺激的动态呈现来模拟策略的使用过程,并通过对于被试正确率和反应时的考察确定了每一名被试使用计数和匹配策略进行量比较的特点。结果表明:(1)与计数策略相比,儿童对于匹配策略的掌握更加成熟,5岁和5岁半组被试使用匹配策略解决量比较问题的正确率更高;(2)在已经掌握计数和匹配两种策略的情况下,仍有一部分儿童更倾向于使用匹配策略来解决量比较问题。     

晋宋之际形神之辩与先秦道家

晋宋之际形神之辩以牟子为先声。从牟子开始便自觉地援用老子思想阐发佛教神不灭论。罗含、孙盛也各自依据先秦道家的气论在形神问题上展开辩论。至慧远,则在更大范围和更高的理论水平上依赖先秦道家思想,把晋宋之际的形神观提升到了当时的顶峰。     

自尊结构的压力调节作用研究

内隐自尊和外显自尊是自尊的两种不同元素,自尊结构指的是外显自尊和内隐自尊在个体身上的不同结合形式。本研究探讨了自尊结构对个体压力的调节作用。研究发现:个体的高内隐自尊/外显自尊结构表现出对压力性生活事件的调节作用,高外显自尊/低内隐自尊、低外显自尊/高内隐自尊、低外显/内隐自尊个体没有表现出压力的调节效应。研究最后探讨了自尊结构研究的可能发展方向。     

质性比较专家与新手的物理学知识结构

通过质性比较方法,本实验刻画了专家与新手在物理学欧姆定律上的知识差异,并发现,与新手相比,专家的知识结构有如下特点:(1)精致化,即拥有更多公式且生成了新公式,表示他们在知识之间形成了更多联系;(2)限制化,即添加更多恒定条件于知识中,从而产生更为明确的行动。此外,本实验在方法学上为细致描述和解释专长的实质提供了可能。