Memories defining the self in Alzheimer’s disease

ABSTRACT

There is a debate over the extent to which personal identity or the self is preserved in patients with Alzheimer’s disease (AD). Autobiographical memory deficits at early stages of AD could contribute to altering patients’ self. However, the nature of the relationship between autobiographical memory deficits and the self in AD has not been much investigated experimentally. In the present study, we aimed to investigate the integrative meaning of self-defining memories (SDMs) in early stages of AD and to analyse its relationship with the self-concept. The results showed that, when compared to the control group, AD patients less frequently extracted meaning from their SDMs and the meaning was less frequently tied to the self. Patients exhibited some altered aspects of the self-concept (i.e., complexity and strength), though some other components still persisted (i.e., valence and certainty). Correlation analyses showed that the impaired integrative meaning in the AD group was correlated with some changes in self-concept. We suggest that integrative meaning may act as a bridge between autobiographical memories and the self-concept, with reduced integration abilities appearing as a potential mechanism for the deterioration of the self-concept in AD.     

The orientation and temperature dependences of dislocation velocity in Ni 3 Al single crystals

The average velocities of screw dislocations in Ni 3 Al single crystals have been directly measured as a function of resolved shear stress (RSS) and orientation in the temperature domain of the flow stress anomaly using the etch-pit technique. The velocity was found to be extremely sensitive to the RSS in all cases. In contrast with ordinary metals, the screw dislocation velocities in Ni 3 Al show anomalous behaviour; under a constant RSS, the velocities decrease dramatically with increasing temperature. Furthermore, the velocities and the tension-compression asymmetry of the velocities depend on the orientation of applied stress.     

Book reviews

D. E. M. Gardner: Susan Isaacs: A First Biography. Methuen Educational Ltd., 1972. Price £1.50.

Marion Milner: On Not Being Able to Paint. Heinemann Educational Books Ltd., London, 1971. Price 90p

Paul Nordoff and Clive Robbins: Therapy in Music for Handicapped Children, with a foreword by Benjamin Britten. Victor Gollancz, London, 1971. Price £1.80.

The Mental Health Book Review Index: an Annual Bibliography of Books and Book Reviews in the Behavioural Sciences, Vol. 17, 1972, XXVI. Price $10.00. Published by the Council on Research in Bibliography, Inc., c/o Research Center for Mental Health, New York University, New York, N.Y. 10003. (Address orders to: Mental Health Book Review Index, c/o Paul Klapper Library, Queens College of the City University of New York, Flushing, New York 11367, U.S.A.)     

Reflex Responses of Human Lip Muscles to Mechanical Stimulation During Speech

The role played by reflex pathways in the production of movement has been a significant issue for motor control theorists interested in a wide variety of motor behaviors. From studies of locomotion and chewing, it appears that gains in reflex pathways can be altered so that activity in these pathways does not produce destabilizing responses during movement. In speech production, recent experimental evidence has been interpreted to suggest that autogenetic lip reflexes (perioral reflexes) are suppressed during sustained phonation or speech production. The present study was conducted to assess the effects of phonation, direction of movement, and ongoing speech production on reflex responses of lip muscles. The present results suggest, in contrast to earlier work, that this reflex pathway is not suppressed during phonation or speech. However, the response may appear to be suppressed or absent because the amplitude of the observed response depends upon the activation levels of the various muscles of the lower lip and, therefore, indirectly on the nature of the gesture the subject is instructed to produce.     

Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse

The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse. Twenty one patients with NMO and 21 normal control subjects received several cognitive tests to assess cognitive function. Head diffusion tensor imaging (DTI) of all patients with NMO were collected with a 3-T MR system. Correlations of cognitive test scores and whole brain FA and MD were examined by voxel-based analysis. Region-of-interest analysis was applied to the significantly correlated regions which the most frequently appeared. We found that NMO patients without visible brain lesions had significantly impaired learning and memory, decreased information processing speed, and damaged attention compared with normal control subjects. These impaired cognitive domains were significantly correlated with FA and MD in local regions of corpus callosum, anterior cingulate and medial frontal cortex. In corpus callosum of NMO patients, mean FA was significantly lower and mean MD higher than normal control subjects. Our findings suggest that cognitive impairments in learning and memory, information processing speed and attention occur in NMO patients without visible brain lesions during acute relapse. The impairments in immediate and short-term memory in NMO patients may be due to information encoding deficits in the process of information acquisition. The corpus callosum of such patients may have local microscopic damages that play a role in cognitive impairments during acute relapse.     

Yerushalmi in a French Key: (French) History and (French) Memory

This article explores the reception of Yosef Hayim Yerushalmi in France in light of the many and diverse reactions his books and lectures engendered at major conferences and meetings. It describes how the American scholar became one of the leading figures among French intellectuals after the first translation of his book Zakhor in 1984 and his first lecture at the École des Hautes Études en Sciences Sociales in 1987, which resulted in a series of annual lectures over the next ten years. Following the readings of Jacques Derrida, Paul Ric?ur, Pierre Vidal-Naquet, and François Furet, among other intellectuals, the eminent standing achieved by Yerushalmi coincided with a special “moment.” At a time when doubt was cast on the testimonies of living witnesses and when the words of Holocaust deniers and of members of the French Resistance were treated on equal terms, the politics of memory challenged the status of history and historians. This paper aims to recover the atmosphere of these past decades and to elucidate how Yerushalmi’s name has become inseparable from the issues linked with the debates about history and memory.     

Protecting Human Health and Security in Digital Europe: How to Deal with the “Privacy Paradox”?

This article is the result of an international research between law and ethics scholars from Universities in France and Switzerland, who have been closely collaborating with technical experts on the design and use of information and communication technologies in the fields of human health and security. The interdisciplinary approach is a unique feature and guarantees important new insights in the social, ethical and legal implications of these technologies for the individual and society as a whole. Its aim is to shed light on the tension between secrecy and transparency in the digital era. A special focus is put from the perspectives of psychology, medical ethics and European law on the contradiction between individuals’ motivations for consented processing of personal data and their fears about unknown disclosure, transferal and sharing of personal data via information and communication technologies (named the “privacy paradox”). Potential benefits and harms for the individual and society resulting from the use of computers, mobile phones, the Internet and social media are being discussed. Furthermore, the authors point out the ethical and legal limitations inherent to the processing of personal data in a democratic society governed by the rule of law. Finally, they seek to demonstrate that the impact of information and communication technology use on the individuals’ well-being, the latter being closely correlated with a high level of fundamental rights protection in Europe, is a promising feature of the socalled “e-democracy” as a new way to collectively attribute meaning to large-scale online actions, motivations and ideas.     

Structural Validation of the Hamilton Depression Rating Scale

Despite the prolific use of the Hamilton Depression Rating Scale (HDRS), there have been no prior studies using confirmatory factor analysis (CFA) to compare competing HDRS latent structures. The current study undertakes this task, examining CFAs on 397 older adults on the most stable latent models previously posited and a new rationally derived model by Cole and Motivala. CFAs were evaluated in their original first-order structure and in hierarchically related counterparts. All hierarchical models performed significantly better than their first-order counterparts. Moreover, the hierarchical Cole and Motivala model was significantly better on all comparative criteria than any of the other models. However, none of the tested models obtained sufficient fit with the data suggesting psychometric, scoring, or content limitations of the scale.