Clamped Corticosterone (B) Reveals the Effect of Endogenous B on Both Facilitated Responsivity to Acute Restraint and Metabolic Responses to Chronic Stress

To determine the effects of both corticosterone (B) and chronic stressors on acute ACTH responses to restraint, young male rats were exposed to streptozotocin-induced diabetes, cold (5-7 degreesC) or intracerebroventricular (icv) neuropeptide Y (NPY) for 5 d and then exposed to restraint within 2 h after lights on. Two groups of rats were studied: intact and adrenalectomized replaced with B pellets that maintained plasma B in the normal mean 24-h range of intact rats. In addition to ACTH and B responses to restraint on d 5, body weight, food intake, fat depots, glucose and other hormones were measured to determine the role of stress-induced elevations in B on energy balance. ACTH responses to restraint were normal in intact rats subjected to diabetes or cold. By contrast, there was no ACTH or B response to restraint in NPY-infused intact rats. All 3 groups of chronically stimulated adrenalectomized rats with clamped B had facilitated ACTH responses to restraint compared to their treatment controls. Overall food intake increased in all groups of stressed rats; however, augmented intake occurred only during the light in intact rats and equally in the light and dark in B-clamped rats. White adipose depot weights were decreased by both diabetes and cold and increased by NPY in intact rats; the decreases with cold and increases with NPY were both blunted and changes in fat stores were not significant in adrenalectomized, B-clamped rats. We conclude that: 1. diabetes- and cold-induced facilitation of restraint-induced afferent input to hypothalamic control of the hypothalamo-pituitary-adrenal (HPA) axis is opposed in intact rats by the elevated feedback signal of B secretion; 2. NPY does not induce facilitation of afferent stress pathways; 3. chronic stimulation of the HPA axis induces acute hyperresponsiveness of hypothalamic neurons to restraint provided that the afferent input of this acute stimulus is not prevented by B feedback; 4. stimulus-induced elevations in B secretion result in day-time feeding; 5. insensitivity of both caloric efficiency and white fat stores to chronic stress in adrenalectomized, B-clamped rats results from loss of normally variable B levels.     

May the force be with you

This paper is a critical assessment of argumentum ad baculum, or appeal to force. Its principal contention is that, contrary to common opinion, there is no general fallacy of ad baculum. Most real-life ad baculums are, in fact, fairly strong. A basic logical form for reconstructed ad baculums is proposed, and a number of heterodoxical conclusions are also advanced and argued for. They include that ad baculum is not necessarily a prudential argument, that ad baculum need not involve force, violence, or threats, and that one can argue ad baculum to oneself. The starting point of the paper, however, is a critical evaluation of three ad baculums from the exercise sets of Irving Copi's well-known Introduction to Logic.     

J. Skelly wright and refusal of treatment

This article is a critical analysis of Judge J. Skelly Wright's “Application of President and Directors of Georgetown College.” Wright's paper concerns the refusal of a Mrs. Jones to allow a blood transfusion needed to save her life and Wright's decision, based on a number of social, medical, legal, religious, and psychological facts, to permit the transfusion. The presentation is a close paraphrase of Wright's own case write-up. Critical expositions of five arguments explicitly advanced by Wright for his decision to allow a transfusion are given, as are attempts to track down other justifying reasons he may have had for his decision.     

Intercultural Study of Personal Space: A Case Study

The study of intercultural differences in personal space attempts to identify factors that could be helpful in guiding people from different cultures to live and work together in international ventures. The objective of this research was to measure interpersonal distance in a cross-cultural environment. Twenty-three participants classified in 4 cultural groups answered an 11-questions interview where the personal distance and orientation between seated interactants were measured. Results showed that Anglo Saxons used the largest zone of personal space, followed by Asians, then Caucasians, and, as expected, Mediterraneans and Latinos used the shortest distance. Where Latinos adopt a face-to-face position, Caucasians tend to orient themselves to the side of the interviewer, which has an impact on interpersonal communication.     

A P.S. on B.S.: Some Remarks on Humbug and Bullshit

While lies have attracted philosophical attention since antiquity, phenomena in the near area have generated considerably less interest. Lately, however, Max Black and Harry Frankfurt have visited a close relative: humbug or bullshit, as it's either more politely or more rudely called. In this article their views on humbug and bullshit are exposed, explained, critiqued, and, ultimately, rejected. An alternative view is then proposed and defended.