Amygdala and periaqueductal gray lesions only partially attenuate unconditional defensive responses in rats exposed to a cat

Defensive responses to a cat were observed in rats given excitotoxic lesions of the central nucleus of the amygdala (ACe), dorsolateral periaqueductal gray (dlPAG), ventral periaqueductal gray (vPAG), or sham lesions. Rats were placed adjacent to a compartment containing a cat. Sham-lesioned rats avoided the area nearest the cat and preferred the area furthest away from the cat. They also exhibited numerous defensive responses including, climbing, escape from the apparatus, and freezing. Rats with lesions of the ACe reacted like the sham lesioned rats by preferring the area of the apparatus furthest from the cat, however they climbed and escaped significantly less than sham lesioned rats. Avoidance of the area adjacent to the cat was attenuated in rats with lesions of the vPAG. Climbing along the walls of the apparatus was also attenuated in rats with lesions of the vPAG. Escapes from the apparatus were not significantly reduced by lesions of the vPAG and dlPAG. Thus, ACe lesions attenuated climbing and eliminated escapes, but did not impair locomotion of the rat away from the cat.     

The aftereffects of ventriloquism: are they sound-frequency specific?

Exposing different sense modalities (like sight, hearing or touch) to repeated simultaneous but spatially discordant stimulations generally causes recalibration of localization processes in one or both of the involved modalities, which is manifested through aftereffects. These provide opportunities for determining the extent of the changes induced by the exposure. Taking the so-called ventriloquism situation, in which synchronized sounds and light flashes are delivered in different locations, we examine if auditory recalibration produced by exposing tones of one frequency to attraction by discordant light flashes generalizes to different frequencies. Contrary to an earlier report, generalization was obtained across two octaves. This result did not depend on which modality attention was forced on through catch trials during exposure. Implications concerning the functional site of recalibration are briefly discussed.     

Measuring the multidimensional self-concept and global self-worth of 6- to 8-year-olds

A downward extension of a Dutch version of Harter's Self-Perception Profile for Children (SPPC) was tested in a Flemish sample of 880 1st to 3rd graders (Mage = 7.18 years, SD = 0.80). In 2nd and 3rd graders, 5 SPPC factors were identified; in 1st graders only 4 were identified. Support was found for the equivalence of structure and measurement for 2nd and 3rd grades and for boys and girls. Most scales possessed reasonable to good internal consistency for these groups. The results support the multidimensionality of self-concept responses for young children and the improving of the distinctiveness of SPPC factors with age. Young children seem to have an ability to verbalize concepts of their global self-worth that can be tapped by self-report measures.     

Age differences in working memory— The roles of storage and selective access

Twenty-four young (23 years) and 24 old (71 years) adults performed arithmetic tasks with working memory loads ranging from 1 to 4. Age groups were equivalent in mean accuracy and speed of arithmetic operations under minimal working memory load, but old adults were slower than young with memory demands >1. Access to a new object in working memory as the basis of computation required additional time. This object-switching cost increased with increases in memory demand, but was unaffected by age, indicating that old adults have no deficit in selective access to working memory.     

How normal is grammatical development in the right hemisphere following hemispherectomy? The root infinitive stage and beyond

We examined the morphosyntax of eight left hemispherectomized children at two different stages and compared it to MLU-matched normals. We found that the language of the hemispherectomies paralleled that of their MLU matches with respect to the specific morphosyntactic characteristics of each stage. Our findings provide strong evidence for the presence of functional categories in all early grammars and demonstrate that grammatical development, regardless of its neural substrate, is highly constrained by UG and follows a narrowly determined course. We discuss our findings within a neurobiological framework in which etiology defines the integrity of the remaining hemisphere, which in turn, determines its potential for linguistic reorganization and/or acquisition.     

Unique transitions between stimuli and responses in SRT tasks: Evidence for the primacy of response predictions

The present experiments aimed at separating the impact stimulus and response predictions have on serial learning and performance in SRT tasks. In Experiment 1, a unique transition between two of four responses in an otherwise random response sequence was triggered by ambiguous stimulus transitions, allowing local response predictions but no stimulus predictions. The data indicated explicit transition knowledge and strong performance benefits. In Experiments 2 and 3, unique transitions between two of four stimuli in otherwise random stimulus sequences allowed local stimulus predictions under conditions of ambiguous response transitions. The data indicated fragmentary explicit transition knowledge but no performance effects. Experiments 4a and 4b reveal that the inefficacy of the unique stimulus transitions in Experiments 2 and 3 was presumably due to the fact that the stimuli differed with respect to conjunctions of response relevant and response irrelevant features which participants did not have to attend. However, although in Experiments 4a and 4b unique transitions between response relevant stimuli were applied, substantial explicit transition knowledge but only marginal performance effects resulted. It is argued i) that in SRT tasks learning mechanisms are addressed that primarily strive for reliable predictions of forthcoming responses and ii) that for these mechanisms to work the predictors have to be attended. Response transitions are easily learned and used because both criteria are fulfilled. In contrast, pure stimulus transitions are learned only if the predictive stimuli are attended, and learned stimulus transitions become effective only to the extent that the predicted stimuli specify the required responses.     

Large-scale ensemble averaging of ambulatory impedance cardiograms

Impedance cardiography has been used increasingly to measure human physiological responses to emotional and mentally engaging stimuli. The validity of large-scale ensemble averaging of ambulatory impedance cardiograms was evaluated for preejection period (PEP), interbeat interval, and dZ/dt_(min) amplitude. We tested whether the average of “classical” 60-sec ensemble averages across periods with fixed activity, posture, physical load, social situation, and location could be accurately estimated from a single large-scale ensemble average spanning these entire periods. Impedance and electrocardiograms were recorded for about 24-h from 21 subjects. Recordings were scored by seven raters, using both methods for each subject. Good agreement (average intraclass correlation coefficient was .91) between both ensemble averaging methods was found for all three cardiac function measures. The results indicate that for unambiguous ambulatory impedance cardiograms, large-scale ensemble averaging is valid, which makes measuring prolonged changes in cardiac sympathetic activity by measuring ambulatory PEP feasible even in large epidemiological samples.     

Effect of inapplicable items in the factor structure of the Spanish version of the Ways of Coping Questionnaire

The aim of this work was to examine how the presence of inapplicable items might change the factor structure of the 1984 Ways of Coping Questionnaire by Lazarus and Folkman. The Spanish version of the Ways of Coping Questionnaire was administered to 156 subjects with university degrees. The 95 women and 61 men whose ages were from 18 and 45 years (M = 27.8, SD = 12.1) were of middle socioeconomic status. All were residents of Buenos Aires. To study whether relevant items modify the factor structure of the Ways of Coping Questionnaire, two factor analyses were carried out, one with items rated as not relevant (Item Mean) and the other with the same items rated as not chosen. In both factor analyses, principal axes method and oblimin rotation were performed, and five factors were considered. Congruence indexes were performed. Analysis showed that not choosing an item because it does not coincide with one's behavior or ideas is not the same as not selecting that item because it does not apply to the current threatening situation. Lack of discrimination between situations when analyzing data leads to a distorted interpretation of the way in which the subject actually behaves or copes with the situation.     

Functional recovery of skilled forelimb use in rats obliged to use the impaired limb after grafting of the frontal cortex lesion with homotopic fetal cortex

The long-term effect of transplanting embryonic frontal cortex into a unilateral frontal cortex lesion has been studied in adult rats. Before surgery, activity in an open field, muscular strength of both forelimbs, and performance in a paw-reaching-for-food task were scored in 26 rats. In 21 animals a unilateral cortex lesion was then made in the forelimb motor area of the hemisphere contralateral to the preferred paw in the paw-reaching-for-food task, while the other 5 animals were sham-operated. On retesting, the lesion animals changed the preferred paw. A solid homotopic transplant of embryonic tissue (embryonic day 17) was then placed in the lesion cavity in 11 of the lesion rats. Three months later neither lesion alone nor lesion plus transplantation affected open field behavior and muscular strength, but the lesion permanently affected performance in the paw-reaching-for-food task, as shown by a change of preferred paw and a functional deficit in the paw contralateral to the lesion. Transplantation ameliorated the deficits caused by the lesion, but this was only evident when animals were forced to reach with the paw contralateral to the lesion plus transplant. The behavioral results were independent of the size of the lesion and graft. Connections between graft and host tissue were studied by means of the fluorescent tracer 1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate (DiI). A dense array of labeled fibers was found in the host cortex adjacent to the transplant. The results suggest that functional recovery depends on grafting but is only evident when the animal is obliged to use the affected limb.     

Ethics and engineering courses at Delft University of Technology: Contents, educational setup and experiences

This article reports on the development and teaching of compulsory courses on ethics and engineering at Delft University of Technology (DUT). Attention is paid to the teaching goals, the educational setup and methods, the contents of the courses, involvement of staff from engineering schools, experiences to date, and challenges for the future. The choices made with respect to the development and teaching of the courses are placed within the European and Dutch context and are compared and contrasted with the American situation and experiences. Previous versions of this article were presented at the meeting of the SEFI Working Group on Engineering Ethics in Rzeszow, Poland, April 29–May 1, 1999 and at the SEFI Annual Conference in Zurich, Switzerland, September 1–3, 1999.