Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates extinction of contextual fear memories

Both genetic and pharmacological studies demonstrated that contextual fear conditioning is critically regulated by cyclic AMP-dependent protein kinase (PKA). Since PKA is a broad range protein kinase, a mechanism for confining its activity is required. It has been shown that intracellular spatial compartmentalization of PKA signaling is mediated by A-kinase anchoring proteins (AKAPs). Here, we investigated the role of PKA anchoring to AKAPs in different stages of the memory process (acquisition, consolidation, retrieval and extinction) using contextual fear conditioning, a hippocampus-dependent learning task. Mice were injected intracerebroventricularly or intrahippocampally with the membrane permeable PKA anchoring disrupting peptides St-Ht31 or St-superAKAP-IS at different time points during the memory process. Blocking PKA anchoring to AKAPs resulted in an impairment of fear memory consolidation. Moreover, disrupted PKA anchoring promoted contextual fear extinction in the mouse hippocampus. We conclude that the temporal and spatial compartmentalization of hippocampal PKA signaling pathways, as achieved by anchoring of PKA to AKAPs, is specifically instrumental in long-term contextual fear memory consolidation and extinction, but not in acquisition and retrieval.     

Gestural overlap in consonant clusters: effects on the fluent speech of stuttering and non-stuttering subjects

This study was designed to investigate if persons who stutter differ from persons who do not stutter in the coproduction of different types of consonant clusters, as measured in the number of dysfluencies and incorrect speech productions, in speech reaction times and in word durations. Based on the Gestural Phonology Model of Browman and Goldstein, two types of consonant clusters were formed: homorganic and heterorganic clusters, both intra-syllabic (CVCC) and inter-syllabic (CVC#CVC). Overall, the results indicated that homorganic clusters elicited more incorrect speech productions and longer reaction times than the heterorganic clusters, but there was no difference between the homorganic and the heterorganic clusters in the word duration data. Persons who stutter showed a higher percentage dysfluencies and a higher percentage incorrect speech productions than PWNS but there were no main group effects in reaction times and word durations. However, there was a significant three-way interaction effect between group, cluster type and cluster place: homorganic clusters elicited longer reaction times than heterorganic clusters, but only in the inter-syllabic condition and only for persons who stutter. These results suggest that the production of two consonants with the same place of articulation across a syllable boundary puts higher demands on motor planning and/or initiation than producing the same cluster at the end of a syllable, in particular for PWS. The findings are discussed in light of current theories on speech motor control in stuttering. EDUCATIONAL OBJECTIVES: The reader will be able to describe: (1) the effect of gestural overlap between consonant clusters on speech reaction time and word duration of people who do and do not stutter and be able to (2) identify the literature in the field of gestural overlap between consonant clusters.     

Forward and backward number translation requires conceptual mediation in both balanced and unbalanced bilinguals

It is much debated whether translation is semantically mediated or based on word-word associations at the lexical level. In 2 experiments with Dutch (L1)-French (L2) bilinguals, the authors showed that there is a semantic number magnitude effect in both forward and backward translation of number words: It takes longer to translate number words representing large quantities (e.g., acht, huit [eight]) than small quantities (e.g., twee, deux [two]). In a 3rd experiment, the authors replicated these effects with number words that had been acquired only just before the translation task. Finally, it was shown that the findings were not due to the restricted semantic context of the stimuli. These findings strongly suggest that translation processes can be semantically mediated in both directions, even at low levels of L2 proficiency.     

A late locus of the distractor frequency effect in picture–word interference: Evidence from event-related potentials

In this study, we investigated how people deal with irrelevant contextual information during speech production. Two main models have been proposed. WEAVER++ assumes that irrelevant information is removed from the production system by an early blocking mechanism. On the other hand, the response exclusion hypothesis assumes a blocking mechanism that operates late, after lexical selection has finished. To delineate between these models, we focused on the distractor frequency effect (i.e., longer picture naming latencies in the context of low-frequency compared to high-frequency words) and measured ERPs concurrently. Behaviorally, the distractor frequency effect was replicated. In the ERPs, three effects were found. One effect occurred very early and is interpreted as an effect of low-level visual feature processing. The two other effects occurred after lexical access and are thus in line with the response exclusion hypothesis.     

The power of ideas: esotericism,historicism, and the limits of discourse

This article is a response to the reviews by Giovanni Filoramo, Olav Hammer, Bernd-Christian Otto, Marco Pasi, and Michael Stausberg of Wouter J. Hanegraaff's book Esotericism and the Academy: Rejected Knowledge in Western Culture. The author attempts to clarify his view of the relation between history and theory, and between intellectual history and discourse theory in particular; he provides a summary of his motivations for writing the book and of its main argument; he concludes by addressing a number of theoretical issues raised by the respondents.     

Developmental Changes in Semantic Verbal Fluency: Analyses of Word Productivity as a Function of Time,Clustering, and Switching

We investigated age-related improvement in semantic category verbal fluency (VF) in 309 Dutch schoolchildren attending first to ninth grade. Quantitative analyses of number of correct responses as a function of time as well as qualitative analyses of clustering and switching were conducted. Overall, Dutch VF task performance, i.e., number of correct responses over 60 seconds, was not established before mid-adolescence. This is in line with previously published studies, using VF number of correct responses over 60 seconds as the main outcome measure and examining VF task performance across other cultures and languages (e.g., Italian, French, Hebrew). Next, mean cluster size, a measure of lexico-semantic knowledge, was not established until at least grade 3. In contrast, performance on the VF outcome measures “number of switches/clusters” was established at least 4 years later. Qualitative and quantitative Design Fluency (DF) outcome measures support the notion that the numbers of switches/clusters are valid measures of higher order cognitive functions, such as strategy use and cognitive flexibility. In line of this, VF number of correct responses during 16–60 seconds, a measure of controlled information processing, is established at least 2 years later (i.e., grades 7–8) than number of correct responses during the first 15 seconds time slide, a measure of automatic processing. Finally, environment, i.e., the level of parental education, primarily affected automatic and lexico-semantic knowledge. No effects of sex on VF performance were found. These data suggest that the alternative scoring methods of VF tasks can be used to acquire knowledge on development of lower and higher order cognitive functions in healthy children and the influence of the environment on it.     

Parallel processing of shape and texture in haptic search

In a haptic search task, one has to determine the presence of a target among distractors. It has been shown that if the target differs from the distractors in two properties, shape and texture, performance is better than in both single-property conditions (Van Polanen, Bergmann Tiest, & Kappers, 2013). The search for a smooth sphere among rough cubical distractors was faster than both the searches for a rough sphere (shape information only) and for a smooth cube (texture information only). This effect was replicated in this study as a baseline. The main focus here was to further investigate the nature of this integration. It was shown that performance is better when the two properties are combined in a single target (smooth sphere), than when located in two separate targets (rough sphere and smooth cube) that are simultaneously present. A race model that assumes independent parallel processing of the two properties could explain the enhanced performance with two properties, but this could only take place effectively when the two properties were located in a single target.     

Assessing moderated mediation in linear models requires fewer confounding assumptions than assessing mediation

It is well known from the mediation analysis literature that the identification of direct and indirect effects relies on strong no unmeasured confounding assumptions of no unmeasured confounding. Even in randomized studies the mediator may still be correlated with unobserved prognostic variables that affect the outcome, in which case the mediator's role in the causal process may not be inferred without bias. In the behavioural and social science literature very little attention has been given so far to the causal assumptions required for moderated mediation analysis. In this paper we focus on the index for moderated mediation, which measures by how much the mediated effect is larger or smaller for varying levels of the moderator. We show that in linear models this index can be estimated without bias in the presence of unmeasured common causes of the moderator, mediator and outcome under certain conditions. Importantly, one can thus use the test for moderated mediation to support evidence for mediation under less stringent confounding conditions. We illustrate our findings with data from a randomized experiment assessing the impact of being primed with social deception upon observer responses to others’ pain, and from an observational study of individuals who ended a romantic relationship assessing the effect of attachment anxiety during the relationship on mental distress 2 years after the break‐up.     

A shortened version of Raven’s standard progressive matrices for children and adolescents

Numerous developmental studies assess general cognitive ability, not as the primary variable of interest, but rather as a background variable. Raven’s Progressive Matrices is an easy to administer non-verbal test that is widely used to measure general cognitive ability. However, the relatively long administration time (up to 45 min) is still a drawback for developmental studies as it often leaves little time to assess the primary variable of interest. Therefore, we used a machine learning approach – regularized regression in combination with cross-validation – to develop a short 15-item version. We did so for two age groups, namely 9 to 12 years and 13 to 16 years. The short versions predicted the scores on the standard full 60-item versions to a very high degree r = 0.89 (9–12 years) and r = 0.93 (13–16 years). We, therefore, recommend using the short version to measure general cognitive ability as a background variable in developmental studies.     

Knowledge of a second language influences auditory word recognition in the native language

Many studies in bilingual visual word recognition have demonstrated that lexical access is not language selective. However, research on bilingual word recognition in the auditory modality has been scarce, and it has yielded mixed results with regard to the degree of this language nonselectivity. In the present study, we investigated whether listening to a second language (L2) is influenced by knowledge of the native language (L1) and, more important, whether listening to the L1 is also influenced by knowledge of an L2. Additionally, we investigated whether the listener's selectivity of lexical access is influenced by the speaker's L1 (and thus his or her accent). With this aim, Dutch-English bilinguals completed an English (Experiment 1) and a Dutch (Experiment 3) auditory lexical decision task. As a control, the English auditory lexical decision task was also completed by English monolinguals (Experiment 2). Targets were pronounced by a native Dutch speaker with English as the L2 (Experiments 1A, 2A, and 3A) or by a native English speaker with Dutch as the L2 (Experiments 1B, 2B, and 3B). In all experiments, Dutch-English bilinguals recognized interlingual homophones (e.g., lief [sweet]-leaf /li:f/) significantly slower than matched control words, whereas the English monolinguals showed no effect. These results indicate that (a) lexical access in bilingual auditory word recognition is not language selective in L2, nor in L1, and (b) language-specific subphonological cues do not annul cross-lingual interactions.