Superior temporal activation in response to dynamic audio-visual emotional cues

Perception of emotion is critical for successful social interaction, yet the neural mechanisms underlying the perception of dynamic, audio-visual emotional cues are poorly understood. Evidence from language and sensory paradigms suggests that the superior temporal sulcus and gyrus (STS/STG) play a key role in the integration of auditory and visual cues. Emotion perception research has focused on static facial cues; however, dynamic audio-visual (AV) cues mimic real-world social cues more accurately than static and/or unimodal stimuli. Novel dynamic AV stimuli were presented using a block design in two fMRI studies, comparing bimodal stimuli to unimodal conditions, and emotional to neutral stimuli. Results suggest that the bilateral superior temporal region plays distinct roles in the perception of emotion and in the integration of auditory and visual cues. Given the greater ecological validity of the stimuli developed for this study, this paradigm may be helpful in elucidating the deficits in emotion perception experienced by clinical populations.     

Aberrant pattern of scanning in prosopagnosia reflects impaired face processing

Visual scanpath recording was used to investigate the information processing strategies used by a prosopagnosic patient, SC, when viewing faces. Compared to controls, SC showed an aberrant pattern of scanning, directing attention away from the internal configuration of facial features (eyes, nose) towards peripheral regions (hair, forehead) of the face. The results suggest that SC's face recognition deficit can be linked to an inability to assemble an accurate and unified face percept due to an abnormal allocation of attention away from the internal face region. Extraction of stimulus attributes necessary for face identity recognition is compromised by an aberrant face scanning pattern.     

Desire to change one’s multimodality and its relationship to the use of different transport means

Using data collected from French employees of a transportation institute and residents of the US San Francisco Bay Area, we operationalize a segmentation of mobility patterns based on objective, subjective, and desired amounts of mobility by various modes and overall. We especially focus on the degree of multimodality in an individual’s current modal mix and desired changes to that mix through the use of a “multimodality index”. The clusters that result showed some similarities and some differences across countries, where the latter are likely due to disparities in the sampling strategies and in the land use/transportation/cultural milieux. In both cases, however, the clusters have useful policy implications, enabling us, for example, to distinguish car users who might be inclined to reduce car use and increase transit use from those who are largely content with their current modal baskets.     

Eyeblink classical conditioning differentiates normal aging from Alzheimer’s disease

Eyeblink classical conditioning is a useful paradigm for the study of the neurobiology of learning, memory, and aging, which also has application in the differential diagnosis of neurodegenerative diseases expressed in advancing age. Converging evidence from studies of eyeblink conditioning in neurological patients and brain imaging in normal adults document parallels in the neural substrates of this form of associative learning in humans and non-human mammals. Age differences in the short-delay procedure (400 ms CS-US interval) appear in middle age in humans and may be caused at least in part by cerebellar cortical changes such as loss of Purkinje cells. Whereas the hippocampus is not essential for conditioning in the delay procedure, disruption of hippocampal cholinergic neurotransmission impairs acquisition and slows the rate of learning. Alzheimer’s disease (AD) profoundly disrupts the hippocampal cholinergic system, and patients with AD consistently perform poorly in eyeblink conditioning. We hypothesize that disruption of hippocampal cholinergic pathways in AD in addition to age-associated Purkinje cell loss results in severely impaired eyeblink conditioning. The earliest pathology in AD occurs in entorhinal cortical input to hippocampus, and eyeblink conditioning may detect this early disruption before declarative learning and memory circuits become impaired. A case study is presented in which eyeblink conditioning detected impending dementia six years before changes on other screening tests indicated impairment. Because eyeblink conditioning is simple, non-threatening, and non-invasive, it may become a useful addition to test batteries designed to differentiate normal aging from mild cognitive impairment that progresses to AD and AD from other types of dementia.     

The Politics of Self-Respect: A Feminist Perspective

Recent liberal moral and political philosophy has placed great emphasis on the good of self-respect. But it is not always evident what is involved in self-respect, nor is it evident how societies can promote it. Assuming that self-respect is highly desirable, I begin by considering how people can live in a self-respecting fashion, and I argue that autonomous envisaging and fulfillment of one's own life plans is necessary for self-respect. I next turn to the question of how societal implementation of rights may affect self-respect, and I urge that discretionary rights, which allow people to decline the benefits they confer, support self-respect more effectively than mandatory rights, which forbid people to refuse the benefits they confer. I conclude by examining the import of these contentions for feminist theory. I believe that my arguments are of particular concern to women because women have traditionally been victimized by a mandatory right to play a distinctively “feminine” role which has undermined their self-respect.     

Connections between reading disability and behavior problems: Testing temporal and causal hypotheses

In this study of children's reading and behavior problem status from Grade 2 to Grade 4 of elementary school, we tested hypotheses concerned with the temporal and causal connections between these two closely associated disorders. Children with both, either, or neither kinds of problems were followed up over 2 years. While reading disability remained stable over time, there was greater variability in behavior problem status. Our data did not support the claim that reading problems lead to the development of behavior problems. Children who were comorbid had the worst outcome at follow-up, suggesting that behavior problems may exacerbate reading delay. Reading-disabled children were lower (albeit in the normal range) on intelligence, but when IQ was controlled, large group differences on reading and spelling were still evident. Attention deficit hyperactivity disorder (ADHD) type behavior problems significantly differentiated children with comorbid problems from children with behavior problems alone. Sex differences were noted in the association, with two-thirds of reading-disabled boys also having behavior problems and two-thirds of reading-disabled girls having no behavior problems, suggesting that pathways to reading disability may be gender specific.This research was supported by a grant from the Australian Research Council. Our thanks to the children, families and teachers for their support of our project.