肿瘤生物学治疗研究的现状及思考

肿瘤发生的相关因素众多,经历正常体细胞的突变,免疫系统对突变细胞的识别及系统对肿瘤细胞的杀伤作用等三个阶段。人类在攻克肿瘤的斗争中农渐认识到,免疫系统对肿瘤细胞的识别是关系到肿瘤是否发生的关键,重建免疫识别是人类攻克肿瘤的希望。     

对分心物特性抑制中位置因素的排除

本研究以汉语单字词为材料,使用反应时技术,考察在归类住条中分心物的位置因素是否也与分心物特性因素一样,影响被试对探测显示中目标的反应时间（RTDT）。结果表明,RTDT不随分心物位置数目变化而变化,只随着分心物特性数目变化而变化．由此得出,象归类这种属于语义表征的、与位置无关的任务中被试并不抑制分心物出现的位置,并可进一步推论,分心物抑制可能是一种灵活机制。     

Optimal sequential designs for on-line item estimation

Replenishing item pools for on-line ability testing requires innovative and efficient data collection designs. By generating localD-optimal designs for selecting individual examinees, and consistently estimating item parameters in the presence of error in the design points, sequential procedures are efficient for on-line item calibration. The estimating error in the on-line ability values is accounted for with an item parameter estimate studied by Stefanski and Carroll. LocallyD-optimaln-point designs are derived using the branch-and-bound algorithm of Welch. In simulations, the overall sequential designs appear to be considerably more efficient than random seeding of items.This report was prepared under the Navy Manpower, Personnel, and Training R&D Program of the Office of the Chief of Naval Research under Contract N00014-87-0696. The authors wish to acknowledge the valuable advice and consultation given by Ronald Armstrong, Charles Davis, Bradford Sympson, Zhaobo Wang, Ing-Long Wu and three anonymous reviewers.     

团体儿童智力测验的编制：目的、准则及其衡鉴

论文阐述了选择编制与世界著名的个别施测的韦克斯勒儿童智力测验相似的但团体施行的儿童智力测验的理由;论述了指导新编测验的五条准则以及选题过程;还报告了对新编测验试用稿的几次相继的因素分析及其它的信度、效度检验结果。     

On getting to know you: The association between the stage of a relationship and reciprocity of self-disclosure

The problem of the study was to determine the association between the stage of relationship and the depth of reciprocal self-disclosures. The subjects were 68 Korean female university students including 17 original subjects, each of whom enlisted one person at each of three relationship stages for disclosing sessions (i.e., with an acquaintance, a friend, and her best friend). Structured conversations were carried on and recorded at each of the relationship stages. The conversations were content analyzed by two judges. The results indicated that (1) there is a linear inverse association between stage of relationship and the generation of nonintimate reciprocal self-disclosures, and (2) there is a curvilinear association between the stage of relationship and the generation of intimate reciprocal self-disclosures.     

Learning to express motion events in English and Korean: the influence of language-specific lexicalization patterns.

English and Korean differ in how they lexicalize the components of motion events. English characteristically conflates Motion with Manner, Cause, or Deixis, and expresses Path separately. Korean, in contrast, conflates Motion with Path and elements of Figure and Ground in transitive clauses for caused Motion, but conflates motion with Deixis and spells out Path and Manner separately in intransitive clauses for spontaneous motion. Children learning English and Korean show sensitivity to language-specific patterns in the way they talk about motion from as early as 17-20 months. For example, learners of English quickly generalize their earliest spatial words--Path particles like up, down, and in--to both spontaneous and caused changes of location and, for up and down, to posture changes, while learners of Korean keep words for spontaneous and caused motion strictly separate and use different words for vertical changes of location and posture changes. These findings challenge the widespread view that children initially map spatial words directly to nonlinguistic spatial concepts, and suggest that they are influenced by the semantic organization of their language virtually from the beginning. We discuss how input and cognition may interact in the early phases of learning to talk about space.     

Emotional labour strategies and job burnout: A meta-analysis of Chinese employees

Emotional labour strategies have a significant impact on job burnout. However, current research results are controversial and unclear. A meta-analysis was conducted to explore the relationship between emotional labour strategies (surface acting and deep acting) and job burnout. A total of 84 empirical studies that included 28,242 participants were selected. The meta-analysis of the relationships between job burnout and surface acting and deep acting included 84 and 75 independent samples respectively. The results show that surface acting had a positive association (r = 0.25) with job burnout, whereas deep acting (r = −0.27) had a negative association with job burnout. Occupational types and measures of emotional labour strategies moderated the relationship between emotional labour strategies and job burnout, but this relationship was not moderated by measures of job burnout.     

Using humor to increase COVID-19 vaccination intention for the unvaccinated: The moderating role of trust in government

Since COVID-19 was declared a global pandemic, scholars and practitioners have put much effort into testing effective advertising strategies for COVID-19 vaccinations. Guided by humor theories, this study aimed to examine (1) the effect of humor on persuading COVID-19 vaccination and (2) the moderating role of trust in government for the unvaccinated population. Across two studies (college students and general adult populations), for lower trust in government individuals, through greater public service advertisement (PSA) processing depth and believability, there was a higher vaccination intention after the humor (non-humor) advertisement. For higher trust in government individuals, there was evidence that the vaccination intention was lowered after the humor (vs. non-humor) message through lowered PSA processing depth and believability. This study expands humor theory into testing COVID-19 vaccination messages while considering an individual psychological factor, trust in the government, that has emerged as an essential determinant to COVID-19 messaging. The contributions to COVID-19 vaccination advertising strategy and advertising to the unvaccinated population, in general, are discussed.     

Role of fresh start mindset framing in reducing stigma and promoting mental health help-seeking behavior

One challenge in promoting mental health help-seeking behaviors is the masculine norm ingrained in the U.S. Using experimental data, this article examines how fresh start mindset (FSM) framing can be effective in helping reduce the stigma associated with mental health help-seeking behaviors and increase the promotion of positive attitudes and word-of-mouth of the mental health messages among men (vs. women). This study uniquely reveals that FSM framing in mental health ad campaigns might help men switch from the mindset that mental health help-seeking behaviors equate to showing weakness to one of help-seeking behaviors as a fresh start. Further, this study demonstrates that males with high issue involvement levels and females with low issue involvement levels respond to FSM framing more favorably. Thus, issue involvement levels form the critical boundary conditions. The authors also reveal that attitudes toward the ads operate as an underlying mechanism in FSM framing effects on responses.     

Parental socialization of mental health in Chinese American families: What parents say and do,and how youth make meaning

Parental mental health socialization is a process by which parents shape how youth develop and maintain beliefs, attitudes, and behaviors regarding mental health and help-seeking behaviors. Although culture shapes parental mental health socialization, few studies have examined specific parental socialization practices regarding mental health and help-seeking, especially as a culturally anchored process. Using a qualitative approach, this study explores youth-reported parental socialization of mental health within Chinese American families by examining focus group data from 69 Chinese American high school and college students. Findings revealed that youth received parental messages that conveyed culturally anchored conceptualizations of mental health that included stigmatized views of mental illness and perceptions of mental distress as not a legitimate problem. Parents responded to youth distress in culturally consonant ways: by encouraging culturally specific coping methods, dismissing or minimizing distress, or responding with silence. Youth engaged in the active interpretation of parental messages through cultural brokering, bridging the gap between their parents’ messages and mainstream notions of mental health and help-seeking. Overall, our findings point to the significant role of culture in parental mental health socialization in Chinese American families and the need to integrate culturally specific understandings of mental health into future interventions for Asian American youth.