Timing the second response in two-response avoidance.

Rats were trained on a free-operant avoidance task requiring two lever presses within R seconds, with the opportunity for each response distinguished by differing stimuli. Response latencies at a variety of response-shock intervals were found to be proportional to the time available for the response. These results are shown to be consonant with a scalar expectancy model of timing behavior.     

Reaction times of younger and older men and temporal contingencies of reinforcement

Influences of extended training and temporal contingencies on reaction time were studied in relation to developmental differences. Older and younger men were trained on a chained schedule in which completion of a variable interval produced a terminal link in which reaction time was measured. The reaction-time procedure involved a conditional discrimination with matching to sample in one component and oddity matching in the other. During baseline training, no time limit was placed on the response to the discrimination choice stimuli. Subsequently, increasingly severe time limits were imposed over a series of sessions. Older and younger men showed increased speeds (decreased reaction times) when temporal contingencies were imposed, and these changes were maintained during post-training baseline sessions when there was unlimited time in which to respond. The younger men generally responded faster than the older ones, and age differences were not appreciably reduced during the course of the experiment. The results indicated the feasibility of studying reaction time in human subjects using operant procedures analogous to those developed for the study of nonverbal organisms.     

Changes in excitability in motor cortex (representation of foreleg) of the dog depending on signal signification of flexor reaction during elaboration of trans switching

Excitability in a cortical representation of a foreleg was determined during elaboration of transswitching in dogs in three variations depending upon the stimulus used as a Conditioned stimulus (CS). If the flexor reaction to direct stimulation of the motor cortex was used as a CS, excitability changes of opposite signs appeared in the cortical representation of the foreleg, the threshold of flexion decreased in the alimentary situation and increased in the defense situation. Such changes in excitability were observed during instrumental conditioned transswitching. If subthreshold stimulation of the motor cortex was used as the CS, the threshold of flexion increased in both situations in approximately equal degree.     

Transfer of training of a new linguistic contrast in voicing

The present study examined the plasticity of the human perceptual system by means of laboratory training procedures designed to modify the perception of the voicing dimension in synthetic speech stimuli. Although the results of earlier laboratory training studies have been ambiguous, recently Pisoni, Aslin, Perey, and Hennessy (1982) have succeeded in altering the perception of labial stop consonants from a two-way contrast in voicing to a three-way contrast. The present study extended these initial results by demonstrating that experience gained from discrimination training on one place of articulation (e.g., labial) can be transferred to another place of articulation (e.g., alveolar) without any additional training on the specific test stimuli. Quantitative analyses of the identification functions showed that the new perceptual categories were stable and displayed well-defined labeling boundaries between categories. Taken together with the earlier findings, these results imply a greater degree of plasticity in the adult speech processing system than has generally been acknowledged in past studies.     

Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects

Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.     

Quantitative amino acid determination in the serum and cerebrospinal fluid in endogenous depressions

The levels of 20 amino acids were measured in the plasma and cerbrospinal fluid of 41 patients with endogenic depressions. The plasma levels of 12 amino acids were found to be significantly lower in the patients than in the control group, but cerebrospinal fluid levels were significantly lower only in the case of taurine, glutamine, phenylalanine and aginine. Comparison of the same amino acid levels in treated and non-treated patients showed that serine and alpha-aminobutyric acid serum concentrations were higher in the nontreated patients. The tyrosine and phenylalanine levels in the cerebrospinal fluid of the patients who had received medicamentous treatment were higher than in the other group.