Hyperactivity and Learning Deficits in Transgenic Mice Bearing a Human Mutant Thyroid Hormone β1 Receptor Gene

Resistance to thyroid hormone (RTH) is a human syndrome mapped to the thyroid receptor β (TRβ) gene on chromosome 3, representing a mutation of the ligandbinding domain of the TRβ gene. The syndrome is characterized by reduced tissue responsiveness to thyroid hormone and elevated serum levels of thyroid hormones. A common behavioral phenotype associated with RTH is attention deficit hyperactivity disorder (ADHD). To test the hypothesis that RTH produces attention deficits and/or hyperactivity, transgenic mice expressing a mutant TRβ gene were generated. The present experiment tested RTH transgenic mice from the PV kindred on behavioral tasks relevant to the primary features of ADHD: hyperactivity, sustained attention (vigilance), learning, and impulsivity. Male transgenic mice showed elevated locomotor activity in an open field compared to male wild-type littermate controls. Both male and female transgenic mice exhibited impaired learning of an autoshaping task, compared to wild-type controls. On a vigilance task in an operant chamber, there were no differences between transgenics and controls on the proportion of hits, response latency, or duration of stimulus tolerated. On an operant go/no-go task measuring sustained attention and impulsivity, there were no differences between controls and transgenics. These results indicate that transgenic mice bearing a mutant human TRβ gene demonstrate several behavioral characteristics of ADHD and may serve a valuable heuristic role in elucidating possible candidate genes in converging pathways for other causes of ADHD.     

Spoken Narrative Assessment: A Supplementary Measure of Children’s Creativity

This study developed a spoken narrative (i.e., storytelling) assessment as a supplementary measure of children’s creativity. Both spoken and gestural contents of children’s spoken narratives were coded to assess their verbal and nonverbal creativity. The psychometric properties of the coding system for the spoken narrative assessment were investigated with 30 Cantonese-speaking children aged six to nine. The internal consistency and the intercoder agreement were good. In addition, children’s scores on the 3 coded variables were moderately correlated with their creativity-relevant skills as measured by Alternate Uses Task (Guilford, 1967) and subjective ratings of creativity provided by judges. Children with higher verbal skills, as measured by Similarities (The Wechsler Intelligence Scale for Children – 4th Edition (Hong Kong); WISC-IV HK), also scored higher in the speech composite of the coding system. The findings showed that the coding system of the spoken narrative assessment is reliable and valid for measuring children’s creativity objectively. An age-related norm will be established in future.     

Psychometric properties of the General Health Questionnaire-12 in a sample of Hong Kong employees

The General Health Questionnaire-12 (GHQ-12) is a widely used instrument for measuring psychological strain, but the factor structure of the GHQ-12 is inconclusive. The present study examined one-factor, two- and three-factor models of the GHQ-12 using structural equations modelling in a longitudinal data-set of Hong Kong employees. The findings supported a two-factor model consisting of a ‘Social Dysfunction’ factor measured by three items, and an ‘Anxiety/Depression’ factor measured by four items. Implications and limitations are discussed.     

Expectations About Couple Therapy Over Time

One common factor of therapy, expectations, has been demonstrated to be a significant contributor to outcome in individual therapy. Despite this, little is known about expectations about couple therapy. This paper presents the qualitative results of a study exploring clients’ expectations before beginning couple therapy and after six sessions. Results indicate that clients form pre-therapy expectations about their therapist, the process of therapy, and their partner. Results also showed that after six sessions, clients’ expectations about therapy were often met or modified in ways that were positive. Implications for therapists and researchers are included.     

Why Should I Respect You? A Critique and a Suggestion for the Justification of Mutual Respect in Contractualism

Contractualism is a normative theory which characterizes principles of right in terms of the idea of mutual respect. In this theory, mutual respect is regarded as having deliberative priority over other values. This essay aims to examine how contractualists can provide a satisfactory justification for prioritizing mutual respect. I will argue that the “value of mutual respect argument,” which is a justification commonly adopted by contractualists, is inadequate because an unconditional priority of mutual respect cannot be grounded on the desirability of a relationship of mutual respect. Then, I will suggest that a “consistency argument” can provide a better justification of why the idea of mutual respect should have priority. Mutual respect is of special importance, not because it is highly desirable, but rather because it is required by an a priori guiding principle of consistency. Individuals become inconsistent if they ask others to respect them as reason-assessing individuals, while at the same time refusing to respect others in the same way.     

Reactions to male-favouring versus female-favouring sex differences: A pre-registered experiment and Southeast Asian replication

Two studies investigated (1) how people react to research describing a sex difference, depending on whether that difference favours males or females, and (2) how accurately people can predict how the average man and woman will react. In Study 1, Western participants (N = 492) viewed a fictional popular-science article describing either a male-favouring or a female-favouring sex difference (i.e., men/women draw better; women/men lie more). Both sexes reacted less positively to the male-favouring differences, judging the findings to be less important, less credible, and more offensive, harmful, and upsetting. Participants predicted that the average man and woman would react more positively to sex differences favouring their own sex. This was true of the average woman, although the level of own-sex favouritism was lower than participants predicted. It was not true, however, of the average man, who – like the average woman – reacted more positively to the female-favouring differences. Study 2 replicated these findings in a Southeast Asian sample (N = 336). Our results are consistent with the idea that both sexes are more protective of women than men, but that both exaggerate the level of same-sex favouritism within each sex – a misconception that could potentially harm relations between the sexes.     

Predicting Substance Use Patterns Among Rural Adults: The Roles of Mothers,Fathers, and Parenthood

This study examined the role of parenthood and parental influences on substance use patterns for 710 stimulant users age 18–61 living in the rural Midwest and Mid‐south U.S. Longitudinal growth analyses showed that a maternal history of drug use was associated with increased baseline drug use severity, lesser declines in severity, and greater plateau of drug use severity over time. Parental conflict was associated with lesser declines in drug use severity, and drug use severity declined more steeply for participants who were themselves parents. Participants with two parents having a history of alcohol use had a greater baseline severity of alcohol use, with paternal history of drug use associated with lower baseline alcohol use severity. These findings demonstrate the importance of identifying parental influences in evaluating adult substance use, and point to the inclusion of parents in efforts to prevent and treat substance use disorders.     

Conjecture and the Division of Justificatory Labour: A Comment on Clayton and Stevens

Res Publica - Clayton and Stevens (Res Publica 20: 65–84, 2014) argue that political liberals should engage with the religiously unreasonable by offering religious responses and showing that...     

Couples' narratives of shared‐self,possessions and consumption experiences

How consumers use possessions and consumption to enact their shared‐self has been underexplored in earlier consumer research. The purpose of this paper is to investigate the emergence of couple‐level (or partnered) shared‐self. A narrative research method was used in Hong Kong, which allowed for an inter‐temporal narrative about the informants' important possessions. Our findings revealed key characteristics regarding the way in which informants' interpretations of shared selves developed over time. This included sharing and negotiating resources (e.g., a house or money) with their partners, integrating similar perspectives (e.g., interests and lifestyle) to their partners', and including their partners as part of the self. This study provides the basis for future research to see how these findings hold up at other stages of partnered relationships. This research provides a conceptualization – a temporal model of couples' shared‐self – that could contribute to and enhance the existing literature on the interrelationship between possessions and the extended self. Copyright © 2016 John Wiley & Sons, Ltd.     

工作记忆成分的年龄相关差异对算术策略运用的预测效应

采用选择/无选范式,借助工作记忆成套测验,在两位数乘法估算问题中探讨了工作记忆系统各成分对不同年龄段个体算术策略运用的预测效应。结果显示:(1)工作记忆的不同成分与年龄之间存在明显的相关。表现为,除视空模板成分外,其他各成分得分随着年龄增长而呈现上升趋势;(2)估算策略运用中,年龄与策略选择显著相关,表现为随着年龄增长,策略选择表现明显提高;(3)估算策略运用中,不同年龄个体的工作记忆不同成分和策略选择表现出不同的联系,中央执行均显示出显著的预测效应,语音环路和视空模板的预测效应均不显著。不同年龄个体的工作记忆不同成分对策略执行的预测效应均不显著。上述发现对于深刻理解工作记忆系统在算术认知策略运用中的作用机制具有重要理论含义。