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581.
Bailey CP Nicholls RE Zhang XL Zhou ZY Müller W Kandel ER Stanton PK 《Learning & memory (Cold Spring Harbor, N.Y.)》2008,15(4):261-270
Cyclic AMP signaling plays a central role in regulating activity at a number of synapses in the brain. We showed previously that pairing activation of receptors that inhibit adenylate cyclase (AC) and reduce the concentration of cyclic AMP, with elevation of the concentration of cyclic GMP is sufficient to elicit a presynaptically expressed form of LTD at Schaffer collateral-CA1 synapses in the hippocampus. To directly test the role of AC inhibition and G-protein signaling in LTD at these synapses, we utilized transgenic mice that express a mutant, constitutively active inhibitory G protein, Galpha(i2), in principal neurons of the forebrain. Transgene expression of Galpha(i2) markedly enhanced LTD and impaired late-phase LTP at Schaffer collateral synapses, with no associated differences in input/output relations, paired-pulse facilitation, or NMDA receptor-gated conductances. When paired with application of a type V phosphodiesterase inhibitor to elevate the concentration of intracellular cyclic GMP, constitutively active Galpha(i2) expression converted the transient depression normally caused by this treatment to an LTD that persisted after the drug was washed out. Moreover, this effect could be mimicked in control slices by pairing type V phosphodiesterase inhibitor application with application of a PKA inhibitor. Electrophysiological recordings of spontaneous excitatory postsynaptic currents and two-photon visualization of vesicular release using FM1-43 revealed that constitutively active Galpha(i2) tonically reduced basal release probability from the rapidly recycling vesicle pool of Schaffer collateral terminals. Our findings support the hypothesis that inhibitory G-protein signaling acts presynaptically to regulate release, and, when paired with elevations in the concentration of cyclic GMP, converts a transient cyclic GMP-induced depression into a long-lasting decrease in release. 相似文献
582.
Wolfgang Wildgen 《Axiomathes》2008,18(1):91-116
The evolution of human symbolic capacity must have been very rapid even in some intermediate stage (e.g. the proto-symbolic
behavior of Homo erectus). Such a rapid process requires a runaway model. The type of very selective and hyperbolically growing
self-organization called “hypercyle” by Eigen and Schuster could explain the rapidity and depth of the evolutionary process,
whereas traditional runaway models of sexual selection seem to be rather implausible in the case of symbolic evolution. We
assume two levels: at the first level the species is adapted to ecological demands and accumulates the effects of this process
in the genome. At the second level a kind of social/cultural knowledge is accumulated via a set of symbolic forms, one of
which is language. Bühler’s model of three basic functions of signs can also be elaborated so that its cyclic structure becomes
apparent. We assume that the hypercyclic process of semiosis and functional differentiation was triggered in 2 my BP (with
the Homo erectus) and got more and more speed with the species Homo sapiens and later. The consequences for the evolutionary
stratification of human languages will be drawn in the last section of the paper. The basic aim of the paper is to provide
a semiotic (and not just a linguistic) explanation of the origin of language which can be linked to relevant models in evolutionary
biology and which exploits the possibilities contained in self-organizing systems.
相似文献
Wolfgang WildgenEmail: |
583.
Wolfgang Palaver 《Dialog》2019,58(1):22-29
Our societies of fear go along with an increase of populist movements in politics. This article explains the basics of populism and shows how easily it joins highly likely political friend‐enemy patterns. Anthropologically, we have to deal with parochial altruism undergirded by a static type of religion. A further step deals with the relationship between politics and fear by referring to terror management theory and its insight into the relationship between mortality and fear. The concluding part addresses ways out of fear and in what way a dynamic type of religion helps to avoid scapegoating and political enmity. 相似文献
584.
Joana Coutinho Patrícia Oliveira‐Silva Eugnia Fernandes Oscar F. Gonalves Diogo Correia Kristin Perrone Mc‐Govern Wolfgang Tschacher 《Family process》2019,58(3):716-733
Previous studies about romantic relationships have shown that the reciprocal influence between partners occurs not only at the behavioral and socio‐emotional levels, but also at the psychophysiological level. This reciprocal influence is expressed in a pattern of physiological synchrony between partners (i.e., coordinated dynamics of the physiological time series). The main aim of the present study was to explore the presence of a pattern of physiological synchrony in electrodermal activity (EDA) during a couple interaction task. A second objective was to compare the synchrony levels during a negative interaction condition versus a positive interaction condition. Finally, we analyzed the association between synchrony and self‐perception of empathy, dyadic empathy, and relationship satisfaction. Thirty‐two couples (64 individuals) participated in this study. Each couple performed a structured interaction task while the EDA of both partners was being registered. The quantification of synchrony was based on the cross‐correlation of both members' EDA time‐series. In order to control for coincidental synchrony, surrogate datasets were created by repeatedly shuffling the original data of spouses X and Y of a dyad and computing synchronies on the basis of the shuffled data (pseudosynchrony values). Our results confirmed the presence of significant EDA synchrony during the interaction. We also found that synchrony was higher during the negative interactions relative to the positive interactions. Additionally, physiological synchrony during positive interaction was higher for those couples in which males scored higher in dyadic empathy. The clinical implications of these findings are discussed. 相似文献
585.
This contribution discusses some fundamental questions of medical ethics in psychotherapy. The problems discussed arise when ?care ethics“, which is based mainly on the Hippocratic Oath as the basis of medical ethics, is rejected. After a short overview of the relevant ethical theories, we ask for values and principles which might serve as a foundation for philosophical reasoning on the doctor-patient-relationship. In particular, we discuss the role of autonomy and informed consent in this relationship, following Beauchamp’s and Childress’ ethical principlism. We try to show the limited scope of the principle of autonomy in psychotherapy. Finally, we make a plea for a dynamic conception of patient autonomy for which we offer some pragmatic reasons. To round this conception off it is illustrated by the metaphor of the lighthouse. 相似文献
586.
Prof. Dr. Wolfgang Senf 《Psychotherapeut》2008,53(5):316-327
Transsexuality is a process with biological, psychological and social aspects. It makes the person concerned feel subjectively appendant to the other gender. The own gender is objectively sensed but it is experienced as foreign. Because of this deep internal certainty, transsexual persons change into their inner chosen gender. This change goes along with a psychosocial alteration of role and in most cases with a hormonal and surgical conversion. Psychotherapy with transsexual persons is known to be difficult and disappointing. The aim of this review is to invalidate these prejudices and to encourage psychotherapeutic treatment of transsexual persons. It also will give all necessary information for this kind of psychotherapy. Generally the psychotherapeutic accompaniment of transsexuals is definitely a meaningful experience for a psychotherapist, in which basic issues of human existence are being touched. 相似文献
587.
419名中国和德国被试参加了本研究,并回答了若干简式心理健康量表。所选的这套量表能对心理治疗不同阶段的效果(Howard’s阶段模型:重新认识期-转变期-康复期)进行测查。本研究目的在于考察这些简式量表能否用于认知-行为治疗跨文化培训项目中的质量管理。结果显示,这些量表在中德两种文化背景下都有很高的信度和效度(聚合效度和敏感性)。尽管项目间的高相关似乎提示心理健康模型只有一个维度,但探索性因素和理论分析则更支持心理健康是一个分为8个亚维度的模型,其中每个亚维度或者与基础情绪、或者与社会性情感相连关联。本文最后就研究结果及其对心理治疗质量控制的意义进行了详细讨论 相似文献
588.
Psychology is frequently confronted with mind-body issues—is there a way by which mentalist and physical approaches to cognition can be integrated? Can the intentional attributes of mind be understood in scientific terms? The authors propose that synergetics, the theory of non-linear complex systems, offers steps towards a possible solution to this conundrum. In particular, we maintain that an essential property of self-organized pattern formation lies within its functionality, this being the ability to optimize, respond and adapt ‘meaningfully’ to environmental constraints. Patterns become functional because they consume in a most efficient manner the gradients which cause their evolution, thereby making synergetic pattern formation appear ‘intentional’. We therefore posit that self-organization phenomena may afford basic explanations for the adaptive, intentional and purposive behavior of many complex systems, in particular of cognitive systems. This present approach elaborates on the second law of thermodynamics. 相似文献
589.
Roebers CM von der Linden N Schneider W Howie P 《Journal of experimental child psychology》2007,97(2):117-137
Two studies were conducted in which two different indicators of metacognitive monitoring were investigated in a complex everyday memory task. In the first phase of each experiment, 8- and 10-year-olds as well as adults were shown a short event (video) and gave judgments of learning, that is, rated their certainty that they would later be able to recall specific details correctly. In the second phase of the experiments, participants underwent a memory interview about the event and in Study 2 also gave confidence judgments, that is, rated their certainty that the provided answers to the memory questions were correct. Results revealed significant influences of memory characteristics on monitoring in that delaying judgments and monitoring judgments concerning irretrievable information affected judgments of learning. From 8 years of age onward, there were relatively appropriate metamemorial monitoring abilities in both indicators. Moderate intraindividual consistency was found across the two measures of metacognitive monitoring, with a tendency toward higher consistency in older age groups. The results are discussed in terms of the adequacy of the underlying theoretical construct. 相似文献
590.
Karl Schweizer Frank Goldhammer Wolfgang Rauch Helfried Moosbrugger 《Personality and individual differences》2007,43(8):1998-2010
The paper reports on an investigation of the convergent and discriminant validity of Raven’s matrices in considering reasoning and spatial abilities. Raven’s advanced progressive matrices (APM) and four scales representing reasoning, visualization, mental rotation and closure were applied to a sample of N = 280 university students. The data were investigated by means of structural equation modeling. The results demonstrated convergent validity of APM with respect to reasoning. In contrast, in investigating discriminant validity substantial correlations of moderate size between APM and the scales representing spatial abilities were observed. However, the investigation of the structure of the prediction of APM revealed that the scales representing spatial abilities did not improve the prediction based on the reasoning scale alone at the latent level. Consequently, it is suggested that Raven’s matrices show good convergent validity and slightly impaired discriminant validity. 相似文献