Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer's disease

Alzheimer's disease (AD) is accompanied by prominent behavioural disturbances. They cause significant distress for both caregivers and patients and can play a major role in the decision to institutionalise AD patients. Recent evidence suggests that cholinergic deficiencies not only contribute to the memory and cognitive abnormalities of AD but are also responsible for some behavioural abnormalities seen over the course of the disease. In this study we assessed the ability of rivastigmine, a pseudo-irreversible cholinesterase inhibitor, to improve behavioural and psychopathologic symptoms in AD. The analysis included 34 patients present in the Germanarm of the international study B303 who received and completed long-term treatment with rivastigmine in the open-label study B305. Assessments of behaviour and psychopathological symptoms were performed using the behavioural component of the Clinicians Interview Based Impression of Change Plus (CIBIC-Plus). Results show that long-term treatment with rivastigmine can slow the progression of behavioural and psychopathological symptoms of AD. Behavioural symptoms showing stabilisation included aggressiveness, activity disturbances, hallucinations and paranoid features. Results also suggest that patients treated earlier with rivastigmine may attain a greater benefit compared with patients whose treatment is delayed 6 months. Further studies examining the effects of rivastigmine on behavioural disturbances in AD are therefore warranted.     

Performance prediction in young children: Effects of skill,metacognition and wishful thinking

Research on children's performance expectations has repeatedly shown that preschoolers and kindergarten children typically overestimate their own performance across a wide range of contexts. In this study, two experiments were carried out with 4- and 6-year-old children to assess the impact of familiarity with the task, memory monitoring, and wishful thinking on children's performance predictions. Results showed that overpredictions were rather due to wishful thinking than to poor metacognition, and that overpredictions were more frequent in unfamiliar as compared to familiar task settings.     

Values and personality

Personality and differential psychology have paid little attention to values research. Consequently, the constructs used in these subdisciplines have developed independently, and evidence regarding the relations of personality to values is minimal. This study seeks to advance our understanding of these relations and to arrive at a theoretical integration of constructs. Starting from recent developments in values theory (Schwartz, 1992; Schwartz and Bilsky, 1987, 1990) and drawing on Maslow's (1955) distinction between ‘deficiency’ and ‘growth’ needs, we elaborate theoretical links between personality and values with special emphasis on structural relations. A set of hypotheses regarding these relations is generated and tested next, using data from a study with 331 German students. These students completed both the Rokeach Value Survey (RVS) and the Freiburg Personality Inventory (FPI), measuring ten primary and two secondary personality variables, namely extraversion and emotionality. Joint Similarity Structure Analyses (SSAs) of values and personality variables were conducted. The findings reveal both meaningful and systematic associations of value priorities with personality variables, confirming the hypothesized structural relationships. The compatibility of our hypotheses with the complex findings of George (1954) using totally different indexes of both values (Allport–Vernon Study of Values) and personality (drawn from Eysenck and Guilford) further supports the theoretical connections proposed in this study.     

A multi-dimensional model for treating families that have survived mother assault

This paper offers a multidimensional family systems approach to treating children and their mothers in families who have survived violence and are in father-absent families. The model incorporates theoretical and clinical ideas from the child witness-to-violence field, the field of traumatic stress, and from feminist thinking. Three areas of intervention are detailed.The authors gratefully acknowledge the suggestions of the reviewers.     

Locus of the effect of specific practice in continuous visual search

Specific practice in a visual search task can result either in a selective elaboration of the feature lists of the task stimuli or in a selective emphasis of their status within the task (targets vs. nontargets). According to the first explanation, which is related to the differentiation principle of perceptual learning, specific practice enhances the operation of stimulus identification. According to the second explanation, which is related to the enrichment principle of perceptual learning, it enhances the operation of response selection. Evidence from two transfer experiments with a reversal paradigm argues in favor of the second view, at least for tasks with easily codable letter stimuli. The results are discussed in the framework of a recent model of information integration in visual search.     

A reconception of meaning

Nelson Goodman's proposal for a reconception of meaning consists in replacing the absolute notion ofsameness of meaning by that oflikeness of meaning (with respect to pertinent contexts). According to this view, synonymy is a matter of degree (of interreplaceability) with identity of expression as a limiting case. Goodman's demonstration that no two expressions are exactly alike in meaning is shown to be unsuccessful. Although it does not make use of quotational contexts for the test of interreplaceability, it is tantamount to their acceptance. Goodman rejects quotational contexts; I argue that they should be accepted. This move offers two advantages.Firstly, and mainly, it allows interlinguistic comparison of meaning, something that has not been deemed possible in the received version of Goodman's account.Secondly, it restores the full scale of likeness of meaning damaged by the renunciation of those contexts that guarantee difference in meaning for diverse expressions.The problems [the paper On Likeness of Meaning] deals with do not seem to me to have quite the paramount importance that is commonly attached to them these days. (Goodman, 1954, p. 54)The subversive power of a radical reorganization of categories should not be underestimated. (Goodman, 1983, p. 2)² Thanks to Oliver R. Scholz and Lorenz Lorenz-Meyer for valuable discussions and advice. Thanks to Geoff Simmons for checking my English. Israel Scheffler and Rolf Eberle both read a preliminary version of this paper. My thanks for their criticism and encouragement.