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31.
Genetically informative longitudinal data on self-reported symptoms of depression allow for an investigation of the causes of stability and change in depression symptoms throughout adult life. In this report, the authors investigated the relative contribution of genetic and environmental influences to symptoms of depression in 83 monozygotic and 84 dizygotic male twin pairs from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study. Participants first completed the Center for Epidemiologic Studies-Depression (CES-D) scale in 1985-1986 and again during 1995-1997. Mean age of twins at baseline was 63 years, range 59 to 70. From cross-sectional genetic analyses we estimated the heritability of CES-D to be 25% (95% confidence interval [CI], 11%-39%) at baseline and 55% (95% CI, 40%-71%) at follow-up. Fitting longitudinal genetic models to the two-wave data, we found that stability of symptoms over the 10-year follow-up was due primarily to continuity of genetic influences. 相似文献
32.
This study investigates recognition of spoken idioms occurring in neutral contexts. Experiment 1 showed that both predictable and non-predictable idiom meanings are available at string offset. Yet, only predictable idiom meanings are active halfway through a string and remain active after the string’s literal conclusion. Experiment 2 showed that the initial fragment of a predictable idiom inhibits recognition of a word providing a congruous, but literal, conclusion to the expression. No comparable effects were obtained with non-predictable idioms. These findings are consistent with the view that spoken idiom identification differs from word recognition and occurs word-by-word, just as with other familiar, multi-lexical phrases.The present study was supported by PRIN 2003–2004. We would like to thank Corrado Cavallero, Simona Collina, Melinda Tucker and Francesco Zardon for their valuable help. 相似文献
33.
Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieval. In this double-blind crossover study, 16 healthy women learned a wordlist containing 15 neutral and 15 negative words. Delayed recall was tested 5h later. Cortisol administered before recall testing significantly reduced retrieval (p<.01). Exploratory follow-up analysis revealed that cortisol significantly impaired retrieval of negative words (p<.01), while having no significant effect on neutral words (p=.47). The current findings could suggest that emotional material is especially sensitive to the memory modulating effects of stress hormones. 相似文献
34.
Intravenous injection of histamine to rabbits was used as a prototype in an investigation of the mechanism of sudden death due to anaphylaxis and other causes. The "dive" reflex, bradycardia due to activation of the ophthalmic branch of the fifth cranial nerve, was induced in thirty-seven of the animals while they inhaled a very small amount of cigarette smoke. Associated with the resulting bradycardia were lowered blood pH and increased serum content of lactic acid and potassium and increased peripheral arterial constriction with elevation of diastolic blood pressure. Intravenous injection of 1 ml of histamine in the presence of the dive reflex induced potentially fatal ventricular arrhythmia, but no cardiac disturbance when administered while the dive reflex was inactive, thereby strongly suggesting that sudden death in anaphylaxis may involve an overzealous response to a normally protective neural reflex. 相似文献
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Susan Wolf 《The Journal of Ethics》1999,3(3):203-223
According to one influential conception of morality, being moral is a matter of acting from or in accordance with a moral point of view, a point of view which is arrived at by abstracting from a more natural, pre-ethical, personal point of view, and recognizing that each person's personal point of view has equal standing. The idea that, were it not for morality, rational persons would act from their respectively personal points of view is, however, simplistic and misleading. Because our nonmoral reasons cannot all be adequately captured as falling within any single, unified and coherent point of view, morality cannot be adequately understood as a matter of abstracting from such points of view and taking them all equally into account. After considering several ways of modifying the initial conception of morality in a way that accommodates the variety of nonmoral reasons that do not have their source in a personal point of view, the paper concludes with the suggestion that we free ourselves more thoroughly from the grip of the metaphor that takes morality as a whole to be a matter of acting in accordance with the judgments of a single unified and coherent point of view. 相似文献
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Standard interventions, such as antidepressive medication or psychotherapy, show only medium effect sizes in the reduction of depressive symptomatology. In addition, medication has problematic and not well accepted side-effects therefore it seems reasonable to look for alternative, cost-effective, easily available treatments which show no side-effects. A large number of studies have demonstrated similar neurophysiological effects of sport as antidepressants or psychotherapies but the crucial question remains unanswered: does sport show antidepressive effects by alleviating depressive symptomatology? Some randomized, controlled studies and all available recent meta-analysis addressing this question are reviewed. This review concludes that randomized control trials including sport activities have similar positive effect sizes as psychotherapy or antidepressant studies. The pre-post effects are in the medium to high range. Such a conclusion is jeopardized by a limited number of methodolically sound studies. It is too early to make evidence-based recommendations about the antidepressive effect of sport. Currently, it can only be speculated about moderators and mechanisms mediating outcome. 相似文献
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Meijssen D Wolf MJ van Bakel H Koldewijn K Kok J van Baar A 《Infant behavior & development》2011,34(1):72-80