Descartes' dreams

Abstract: René Descartes is often regarded as the ‘father of modern philosophy’. He was a key figure in instigating the scientific revolution that has been so influential in shaping our modern world. He has been revered and reviled in almost equal measure for this role; on the one hand seen as liberating science from religion, on the other as splitting soul from body and man from nature. He dates the founding of his philosophical methods to the night of 10^th November 1619 and in particular to three powerful dreams he had that night. This article utilizes Descartes' own interpretations of the dreams, supported by biographical material, as well as contemporary neuroscientific and psychoanalytic theory, to reach a new understanding of them. It is argued that the dreams can be understood as depicting Descartes' personal journey from a state of mind‐body dissociation to one of mind‐body deintegration. This personal journey may have implications for a parallel journey from Renaissance to modern culture and from modernity to post‐modern culture.     

Reliability and validity of a new scale to measure prejudice: The GRISMS

The goal of the present research was to assess the reliability and validity of the fiftyitem Modified Godfrey-Richman ISM Scale (M-GRISMS). The sample consisted of seventy-one female and sixty male introductory psychology students. Test items included various ethnic groups (Racism subscale), religious groups (Religion subscale), and the Heterosexist and Sexist subscales. Each of these was parsed into various subcategories, e.g., the Racism subscale assessed attitudes toward African-Americans, Asian-Americans, European-Americans, Hispanics, and Native Americans. The final version of the M-GRISMS (the M-GRISMS-M) was found to be highly reliable and valid. Eight independent factors traversed two or more “isms.”     

Hertzmann,Leezah & Newbigin,Juliet (Eds.). Sexuality and Gender Now: Moving Beyond Heteronormativity. The Tavistock Clinic Series. London: Routledge. 2019. Pp. 358. Pbk. £29.99.

In this paper the author argues that trans-identification and its associated medical treatment can constitute an attempt to evade experiences of psychological distress. This occurs on three levels. Firstly, the trans person themselves may seek to evade dysregulated affects associated with such experiences as attachment trauma, childhood abuse, and ego-alien sexual feelings. Secondly, therapists may attempt to evade feelings, such as fear and hatred, evoked by engaging with these dysregulated affects. Thirdly, we, as a society, may wish to evade acknowledging the reality of such trauma, abuse and sexual distress by hypothesizing that trans-identification is a biological issue, best treated medically. The author argues that the quality of evidence supporting the biomedical approach is extremely poor. This puts young trans people at risk of receiving potentially damaging medical treatment they may later seek to reverse or come to regret, while their underlying psychological issues remain unaddressed.     

Insulin receptor substrate 2 is a negative regulator of memory formation

Insulin has been shown to impact on learning and memory in both humans and animals, but the downstream signaling mechanisms involved are poorly characterized. Insulin receptor substrate-2 (Irs2) is an adaptor protein that couples activation of insulin- and insulin-like growth factor-1 receptors to downstream signaling pathways. Here, we have deleted Irs2, either in the whole brain or selectively in the forebrain, using the nestin Cre- or D6 Cre-deleter mouse lines, respectively. We show that brain- and forebrain-specific Irs2 knockout mice have enhanced hippocampal spatial reference memory. Furthermore, NesCreIrs2KO mice have enhanced spatial working memory and contextual- and cued-fear memory. Deletion of Irs2 in the brain also increases PSD-95 expression and the density of dendritic spines in hippocampal area CA1, possibly reflecting an increase in the number of excitatory synapses per neuron in the hippocampus that can become activated during memory formation. This increase in activated excitatory synapses might underlie the improved hippocampal memory formation observed in NesCreIrs2KO mice. Overall, these results suggest that Irs2 acts as a negative regulator on memory formation by restricting dendritic spine generation.