Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

Why child neuropsychiatry?]

The author gives a brief survey of the development of Child-Neuropsychiatry in the G.D.R. and subsequently gives reasons for the decision in favor of the unity of neurology and psychiatry as applied to children and juveniles, which is in contrast to developments in other countries. In addition to hygienic, economic, organizational, and medical considerations, this decision was also determined by the fact that a Child-Neuropsychiatrist must, in his practical work as a subspecialist, be able to head a multiprofessional team and, thus, help assure optimum development of a child's personality.     

Mothers and fathers,sons and daughters: Perceptions of young adults

Arguing that little is known about the ways in which mothers and fathers in intact households divide labor and influence children, a multifaceted questionnaire was devised to explore college students' perceptions of their parents. Mothers had greater responsibility for nurturance and fathers were clearer models of masculine personality traits but, in general, parents were much more similar than different. On 28 of the 43 comparisons between mothers and fathers there were no significant differences. There were, moreover, no main effects involving sex of child. Daughters and sons were treated in similar fashion. Overall, the data suggest that no nonbiological aspect of parenting is uniquely associated with either parent and that parents may not be the primary agents of differential sex-role socialization.I am indebted to my colleagues Elizabeth Allgeier and Tom Rywick. The former provided insightful and constructive criticism, the latter invaluable statistical help. I also wish to thank my student Robert Qulia for his research assistance.     

Strategies of rule discovery in an inference task

It has long been known that subjects in certain inference tasks will seek evidence which can confirm their present hypotheses, even in situations where disconfirmatory evidence could be more informative. We sought to alter this tendency in a series of experiments which employed a rule discovery task, the 2-4-6 problem first described by Wason. The first experiment instructionally modified subjects confirmatory tendencies. While a disconfirmatory strategy was easily induced, it did not lead to greater efficiency in discovering the rule. The second experiment introduced subjects to the possibility of disconfirmation only after they had developed a strongly held hypothesis through the use of confirmatory evidence. This manipulation also failed to alter the efficiency of rule discovery. In the third experiment, subjects were taught to use multiple hypotheses at each step, in the manner of Platt's “Strong Inference”. This operation actually worsened performance. Finally, in the fourth experiment, the structure of the problem was altered slightly by asking subjects to seek two interrelated rules. A dramatic increase in performance resulted, perhaps because information which in previous tasks was seen as merely erroneous could now be related to an alternative rule. The four studies have broad implications for the psychological study of inference processes in general, and for the study of scientific inference in particular.     

The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

Disintegrated experience: the dissociative disorders revisited

We present proposed changes to the dissociative disorders section of the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders and review the concept of pathological and nonpathological dissociation, including empirical findings on the relations between trauma and dissociative phenomenology and between dissociation and hypnosis. The most important proposals include the creation of two new diagnostic entities, brief reactive dissociative disorder and transient dissociative disturbance, and the readoption of the criterion of amnesia for a multiple personality disorder diagnosis. We conclude that further work on dissociative processes will provide an important link between clinical and experimental approaches to human cognition, emotion, and personality.