The usefulness of the Western Aphasia Battery for differential diagnosis of Alzheimer dementia and focal stroke syndromes: preliminary evidence.

We assessed the usefulness of the Western Aphasia Battery for distinguishing the language disturbances caused by Alzheimer dementia (AD) from those caused by stroke. Using discriminant function analyses, the multiple variable "aphasia quotient--reading quotient--writing quotient" classified 29 (72.5%) of the 40 patients correctly. These 29 patients included 8 of 10 patients with left hemisphere infarction and fluent aphasia; 6 of 10 with AD; 5 of 10 patients with right hemisphere infarction; and all 10 of the neurologically normal control subjects. The patients with AD and those with right hemisphere stroke were the most difficult to classify using the aphasia battery.     

Nifedipine blocks retention of a visual discrimination task in chicks.

Reports that the dihydropyridine Ca2+ channel antagonists may facilitate memory led to the present study of the behavioral effects of nifedipine. Ninety-two 4-day-old male chicks received 0, 100 nM, 100 microM, or 10 mM nifedipine. Drugs were administered in volumes of 2 microliters into the fourth cerebral ventricle 5 min before training on a visual discrimination task. Nifedipine did not produce any detectable changes in behavior during acquisition trials. Retention, however, was impaired 24 h after training in the 100 nM and 100 microM nifedipine-treated chicks, which made significantly more errors than controls. Nifedipine did not affect the amount of time required to complete the task. No effects on body weight gain were detected, suggesting that the memory impairment was not due to a change in feeding behavior. These data are discussed in terms of the role of calcium-dependent processes in memory.     

General slowing alone cannot explain age-related search effects: reply to Cerella (1991)

Cerella (1991) has argued that the performance of older adults in the Fisk and Rogers (1991) study is a linear function of the performance of younger adults that is independent of task-specific cognitive requirements. We demonstrate that this is not the case. First, we show that the scatter plot analyses used by Cerella can hide the very task-specific age-related slowing they were designed to reveal. Second, we demonstrate that the percentage of variance explained by such analyses can be misleading. Third, we show that there are reliable differences across tasks in the parameters relating younger and older adults' performance. Finally, we argue that the general, task-independent proportionate slowing that Cerella suggested explains so much of the variance in age-related performance is actually an average slowing that is a function of a relatively small task-independent and a relatively large task-dependent factor.     

Impairment of spontaneous alternation performance by an NMDA antagonist: attenuation with non-NMDA treatments.

N-Methyl-D-aspartate (NMDA) receptor antagonists disrupt learning on a variety of tasks. Previous findings indicate that glucose, naloxone, and physostigmine ameliorate learning deficits produced by several treatments. The present experiment examines whether these agents also reverse the amnestic effects of NMDA receptor blockade. Mice were tested for spontaneous alternation performance in a Y-maze. The animals received either saline or the NMDA antagonist, NPC 12626 (35 mg/kg, IP), 50 min prior to testing and received an additional injection of saline, glucose, naloxone, or physostigmine 30 min prior to testing. NPC 12626 significantly decreased alternation scores. Glucose (250 mg/kg), physostigmine (0.01 mg/kg), and naloxone (1 mg/kg) reversed the effects of NPC 12626. Thus, impairments of learning after NMDA receptor blockade share with other amnestic conditions the susceptibility to attenuation by glucose, naloxone, and physostigmine.     

Conditioned taste aversions support drug discrimination learning at low dosages of morphine.

The present experiment shows that a conditioned taste aversion procedure can support discrimination learning at dosages of morphine comparable to those required to produce motivational effects. Sprague-Dawley rats were injected with 4.0 mg/kg morphine sulfate prior to a saccharin-lithium chloride pairing, and physiological saline prior to a saccharin-saline pairing. The rats avoided the saccharin solution following the administration of morphine and consumed significantly more saccharin following saline administration after four discrimination cycles. After this initial discrimination the subjects were trained with progressively lower doses of morphine. Discrimination learning was apparent at doses of 2.0, 1.5, 1.0, 0.75 and 0.5 mg/kg. Animals initially trained with 1.0 mg/kg morphine also learned the discrimination but required 10 training cycles. After this initial discrimination the subjects were trained with progressively lower dosages of morphine and showed a discrimination at a dosage of 0.5 mg/kg.     

Reinstatement of latent inhibition following a reminder treatment in a conditioned taste aversion paradigm.

Reminder treatments have been shown to facilitate the retrieval of a variety of conditioned responses. Whether or not similar results would occur with an experimental paradigm which involves primarily memory for a stimulus, i.e., where no particular response is specified, is unclear. Accordingly, using Sprague-Dawley rats, we employed a latent inhibition paradigm with a long (10 days) retention interval between sucrose (CS) preexposure and sucrose-illness pairing (training). The results demonstrated a loss of latent inhibition following the 10-day retention interval suggesting "forgetting" of the CS preexposure. However, placing a single reminder exposure to the CS within the preexposure-to-training interval reinstated the preexposure effect. Controls indicated that in the absence of the initial preexposure the reminder per se did not produce latent inhibition. Thus, a reminder can reinstate a stimulus attribute (flavor representation) and explicit conditioned responses.     

Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease.

Although visuoconstructive impairment has been reported in both Alzheimer's (DAT) and Huntington's (HD) disease, there is little knowledge concerning how this cognitive deficit differs quantitatively and qualitatively in these two progressive dementias. To address this issue, the present study compared performances on the Clock Drawing Test (CDT: command and copy) of 25 DAT patients, 25 equally demented HD patients, and 25 elderly normal controls (NC). In the command condition, both patients groups were significantly impaired compared to the NC group. Although there was no significant difference between DAT and HD patients' total quantitative scores, a qualitative error analysis revealed a number of dissociations between the two patient groups. Graphic difficulties, very common in HD patients, were virtually absent in DAT patients; in contrast, conceptual errors were almost exclusively seen in DAT patients and were related to the severity of their dementia. Perseveration and "stimulus-bound" responses were also more frequent in DAT patients, and both groups made visuospatial errors. In the copy condition, the DAT, but not the HD, patients evidenced a marked improvement in performance. These results indicate that while both DAT and HD patients have significant visuoconstructive difficulties even in the early stages of their disorders, the specific cognitive processes underlying their quantitative impairments are quite different. It is possible that the DAT patients' conceptual errors are yet another indicator of the deterioration of their semantic knowledge.     

TOWARD A FEMINIST UNDERSTANDING OF WOMEN AND POWER

Both psychologists and feminists believe power is an important and ubiquitous concept, yet its definition and scope eludes both groups. In this introduction to a special issue on women and power, we suggest three points to help organize and interpret research in the area. First, definitions of power should center around the distinction between "power-over," the domination and control of one person or group over another, and "power-to" or personal empowerment. Second, power can be analyzed at different levels—societal, organizational, interpersonal, and individual—and, importantly, these levels interact. Third, power differences frequently underlie what appear to be gender differences in behavior; as society is currently configured, power and gender are never independent. Although the articles in this special issue often ask more questions than they answer, the present volume adds a feminist perspective to the psychological study of power.     

It's never too late to change: A group psychotherapy experience for older women

Group psychotherapy in a mixed gender group is seen as useful for treatment of the unique existential and emotional problems of the older woman. This article describes the first year of a psychotherapy group for older adults, four women and three men in their early fifties to late sixties. Some issues discussed unique to this age group were loss, isolation, changing body image, and changed political views. There were differences in reactions between the men and women. The major value of group psychotherapy for older women is seen as providing a safe arena for exploring current issues, integrating a sense of self, enhancing self-worth, and overcoming isolation and despair.     

An exploratory study of videotapes of long-term group psychotherapy of outpatients with major and chronic mental illness

This study explored patterns emerging in videotaped sessions of group psychotherapy with seven outpatients of a large mental health facility. The 22 sessions spanned the 12th to 27th months of the group's existence. Group members had long histories (25–50 years) of symptoms characteristic of schizophrenia. Each session was rated on the Group Environment Scale. One session from a group in its earlier stages was also rated on the same instrument to give some indication of baseline patterns. Analyses of changes across the 15 months were not statistically significant. However, some GES subscales, including Cohesion, Independence, and Self-Discovery, showed relatively high mean levels across the 15-month period. These elevations are discussed as suggesting the codevelopment of orientations that have sometimes been viewed as incompatible and unattainable for schizophrenics. Interpreted clinically, the GES patterns help to elaborate recent findings about the relatively good success of long-term group therapy with such populations. The study, although merely suggestive, illustrates the potential for gleaning solid and clinically useful data from group psychotherapy research.The authors would like to thank Drs. Jill Rierdan, Nina Fieldsteel, Joseph Christy, and an anonymous reviewer for their suggestions, Kendra Bryant for serving as the reliability rater, and Janet Eltinge for her skilled videotaping.