Generalization gradients of inhibition following auditory discrimination learning

A more direct method than the usual ones for obtaining inhibitory gradients requires that the dimension of the nonreinforced stimulus selected for testing be orthogonal to the dimensions of the reinforced stimulus. In that case, the test points along the inhibitory gradient are equally distant from the reinforced stimulus. An attempt was made to realize this condition by obtaining inhibitory gradients along the frequency dimension of a pure tone after discrimination training in which the nonreinforced stimulus was a pure tone (or tones), and the reinforced stimulus was either white noise or the absence of a tone. The results showed that some degree of specific inhibitory control was exerted by the frequency of the tone, although the gradients were broad and shallow in slope.

A further experiment was conducted to see whether the modification of an excitatory gradient resulting from training to discriminate neighboring tones could arise from a simple interaction of inhibitory and excitatory gradients. The results indicated that it could not, since discrimination training produced a concentration of responding in the vicinity of the reinforced stimulus which cannot be derived from any plausible gradient of inhibition.

     

Changeover delay and concurrent schedules: some effects on relative performance measures

The pigeon and the rat partition total response output between both schedules of a concurrent variable-interval pair. The quantitative nature of a partition seems critically dependent on the relative rates with which the two schedules provide reinforcements for responding, in addition to the changeover delay. The manner in which the changeover delay controls the partition was studied by varying the duration of the changeover delay from 0 to 20 sec with each of two pairs of concurrent variable-interval schedules, viz., Conc VI 1.5-min VI 1.5-min and Conc VI 1-min VI 3-min. Rats served as the subjects and brain stimulation was employed as the reinforcer. When the schedules were Conc VI 1.5-min VI 1.5-min, relative response rate approximated 0.50 at all values of the changeover delay. When the schedules were Conc VI 1-min VI 3-min, relative response rate, computed with respect to the VI 1-min schedule, increased when the duration of the changeover delay increased. Changeover rate decreased when the duration of the changeover delay increased. The decrease was the same for both VI schedules of the Conc VI 1.5-min VI 1.5-min pair but was more rapid for the VI 3-min schedule of the Conc VI 1-min VI 3-min pair.     

Drug effects in squirrel monkeys trained on a multiple schedule with a punishment contingency

The behavior of four monkeys trained on a multiple schedule was differentially sensitive to selected pharmacological agents. The three components of the multiple schedule were: (1) a variable-interval schedule in which responses were reinforced on the average of once per minute; (2) a concurrent schedule in which every tenth response was reinforced and every fifteenth response, on the average, was shocked; and, (3) a neutral stimulus in the presence of which responses were neither reinforced nor shocked. Pentobarbital, chlordiazepoxide, and meprobamate increased responding during each of the components. Scopolamine and d-amphetamine decreased variable-interval performance, had minimal effects on performance during the concurrent-schedule component, and increased responding in the presence of the neutral stimulus. Chlorpromazine decreased variable-interval responding and had slight effects on the responding during the other two components.     

A simple histological technique for localizing electrode tracks and lesions within the brain.

Histological procedures are necessary in brain stimulation or lesion work to determine the neural area which has been stimulated or damaged. Preparation of brain tissue often involves embedding and staining techniques that require specialized training, and the expense of a technician and a large assortment of special apparatus and supplies. In addition, the results of such techniques are unavailable for at least several days. A photographic method, which requires little special skill and a minimal amount of apparatus, is described here. Results can be available within minutes after the subject is sacrificed. This method has been shown to be adequate for the gross determination of lesion boundaries and electrode or cannula tip loci in brains of rats, cats, and squirrel monkeys.     

Discrimination learning by macaca mulatta with option to switch between S+ and S−

Three rhesus monkeys were trained to press either of two response keys. A response on the reinforcement key during presentation of the reinforced stimulus produced a sucrose pellet followed by an intertrial interval, but during presentation of the unreinforced stimulus produced only the intertrial interval. A response on the switching key changed the discriminative stimulus from reinforced to unreinforced or from unreinforced to reinforced. The reinforced stimulus was presented automatically on half the trials, but could be produced only by a switching response on the other half. Switching tended to occur in three distinct stages during acquisition of discriminative behavior. The first stage was identified as "nondiscriminative switching"; the second as "nonswitching"; and the third as "discriminative switching".     

Several methods for teaching serial position sequences to monkeys

Three keys were available for monkeys to press. The objective was to teach the animals to press the keys in sequences up to 10 members in length. With fading procedures, a light that cued the correct key at a given serial member of the sequence faded out slightly each time the animal selected it, and became slightly brighter after the animal made an error at that sequence member. The correct keys were faded out, starting from the end of the sequence and proceeding toward the beginning. With control procedures, the cue lights were turned off suddenly, rather than being faded gradually. In almost every instance, the animals learned a longer series of unlighted key positions with the fading procedures than they did when each key-light was turned off suddenly. Also, requiring the animals to press a series of keys cued by lights before they could reach the sequence members they were to learn hampered them in learning the later serial members. By using several different sequences, it was possible to replicate these findings within the individual animal.     

An inexpensive electro-fistular swivel for negative feedback control of self-stimulation

A swivel was developed for concurrent intraorganismic fluid injection and intracranial electrical stimulation of the unrestrained rat. Effects of various intragastric injections on bar-pressing maintained by electrical stimulation of the hypothalamus were studied. In some subjects, intragastric injections of either water or milk decreased the rate of responding. This decrease resulted from pauses in responding rather than from decreases in the local rates of responding. The decrement in responding occurred at a lower gastric volume during milk injection than during water injection. In other subjects, however, neither water, milk, nor 32% sucrose injections affected the rate of self-stimulation.