The Ontological Status of Human DNA: Is It Not First and Foremost a Biological ``File Self'?

This paper investigates which of the various legal notions proposed for human DNA is the most appropriate from an ontological viewpoint - unique legal status, private property, common property, person, or information. The focus is on the difficulties that private property, common property and person present. By using Harré's notion of "file-self" we argue that, ontologically, the most appropriate legal notion to be applied is information. This has consequences for storage, control and use of genetic information as well as identifiable human body material.     

Sustained efficacy of dialectical behaviour therapy for borderline personality disorder

Dialectical Behaviour Therapy (DBT) is considered one of the most promising treatments for borderline personality disorder (BPD). Recently, we reported significantly positive effects of 12 months DBT on parasuicidal behaviour and impulsivity in a mixed group of female BPD patients with and without substance abuse. Fifty-eight women with BPD were randomly assigned to either 52 weeks of DBT or treatment as usual (TAU). Follow-up assessment took place at 78 weeks, i.e., 6 months after discontinuation of DBT. Participants were clinical referrals from addiction treatment and psychiatric services. Outcome measures included parasuicidal behaviour, impulsivity and substance abuse. Six months after treatment discontinuation, the benefits of DBT over TAU in terms of lower levels of parasuicidal and impulsive behaviours, and in alcohol use, sustained. No differences between the treatment conditions were found for drug abuse. In conclusion, DBT seems to have a sustained effect on some of the core symptoms of BPD and on alcohol problems in a mixed population of female borderline patients with and without substance abuse problems.     

Linear separability in superordinate natural language concepts

Two experiments are reported in which linear separability was investigated in superordinate natural language concept pairs (e.g., toiletry-sewing gear). Representations of the exemplars of semantically related concept pairs were derived in two to five dimensions using multidimensional scaling (MDS) of similarities based on possession of the concept features. Next, category membership, obtained from an exemplar generation study (in Experiment 1) and from a forced-choice classification task (in Experiment 2) was predicted from the coordinates of the MDS representation using log linear analysis. The results showed that all natural kind concept pairs were perfectly linearly separable, whereas artifact concept pairs showed several violations. Clear linear separability of natural language concept pairs is in line with independent cue models. The violations in the artifact pairs, however, yield clear evidence against the independent cue models.     

The influence of irrelevant stimulus changes on stimulus and response repetition effects

In this study the influence of irrelevant stimulus changes from one trial to another in a serial reaction time task was investigated. Two experiments were performed in which subjects were required to respond to stimulus colour. Four colours were mapped on two response keys, so that colour and response repetition effects could be dissociated. In Experiment 1, the irrelevant stimulus dimension was location and in Experiment 2 it was shape. Both experiments were performed with a short and a long response-stimulus interval (RSI)-condition. In both experiments, the irrelevant dimension influenced the response repetition effect but not the colour repetition effect. In the reaction times, a response alternation effect was observed only when the irrelevant location of the stimulus changed in the long RSI-condition. The error rates showed a response alternation benefit for both irrelevant dimensions, in the short and the long RSI-condition. The benefit for response alternations is explained in terms of a response bias towards change that is triggered by a changing stimulus feature. We assume that the response bias is stronger for location than for colour and that accuracy is more sensitive to this bias than response latencies.     

Using response times to detect aberrant responses in computerized adaptive testing

A lognormal model for response times is used to check response times for aberrances in examinee behavior on computerized adaptive tests. Both classical procedures and Bayesian posterior predictive checks are presented. For a fixed examinee, responses and response times are independent; checks based on response times offer thus information independent of the results of checks on response patterns. Empirical examples of the use of classical and Bayesian checks for detecting two different types of aberrances in response times are presented. The detection rates for the Bayesian checks outperformed those for the classical checks, but at the cost of higher false-alarm rates. A guideline for the choice between the two types of checks is offered.This study received funding from the Law School Admission Council (LSAC). The opinions and conclusions contained in this paper are those of the authors and do not necessarily reflect the policy and position of LSAC. The authors are most indebted to Wim M. M. Tielen for his computational assistance and to the US Defense Manpower Data Center for the permission to use the ASVAB data set in the empirical examples.     

Velocity dependence of the interocular transfer of dynamic motion aftereffects

It is well established that motion aftereffects (MAEs) can show interocular transfer (IOT); that is, motion adaptation in one eye can give a MAE in the other eye. Different quantification methods and different test stimuli have been shown to give different IOT magnitudes, varying from no to almost full IOT. In this study, we examine to what extent IOT of the dynamic MAE (dMAE), that is the MAE seen with a dynamic noise test pattern, varies with velocity of the adaptation stimulus. We measured strength of dMAE by a nulling method. The aftereffect induced by adaptation to a moving random-pixel array was compensated (nulled), during a brief dynamic test period, by the same kind of motion stimulus of variable luminance signal-to-noise ratio (LSNR). The LSNR nulling value was determined in a Quest-staircase procedure. We found that velocity has a strong effect on the magnitude of IOT for the dMAE. For increasing speeds from 1.5 deg s(-1) to 24 deg s(-1) average IOT values increased about linearly from 18% to 63% or from 32% to 83%, depending on IOT definition. The finding that dMAEs transfer to an increasing extent as speed increases, suggests that binocular cells play a more dominant role at higher speeds.