Cerebral laterality and depression: differences in perceptual asymmetry among diagnostic subtypes

Examined the influence of diagnostic subtype of depression on perceptual asymmetry for dichotic listening and visual tachistoscopic tasks. A total of 65 unmedicated patients with major depressive disorders and 30 normal controls were tested on a verbal and nonverbal task in each modality. Patients diagnosed according to the DSM-III with melancholia had abnormal perceptual asymmetry for dichotic nonsense syllable and complex tone tasks. In contrast, patients having a nonmelancholic "atypical depression" (reactivity of mood with preserved pleasure capacity and associated features) did not differ from normal controls on these tasks, but had an increased incidence of left handedness. Bipolar depression (history of hypomania) differed from unipolar depression in showing abnormal perceptual asymmetry for a tachistoscopic dot enumeration task. Alterations of perceptual asymmetry in melancholia and bipolar depression were consistent with hypothesized right hemisphere dysfunction.     

A cross-sequential analysis of developmental differences in speed of visual information processing

Development of processing speed was examined in three backward masking studies. The first verified the central nature of backward masking for children aged 8 and 11 years and for adults. The second suggested that task requirements were equivalent for children similar to those in Study 1, and that age differences in performance were not attributable to nonprocessing variables. The main cross-sequential study estimated speed of processing in 80 children (approximately 6 years to 13 years) and young adults using an inspection time task. Target exposure duration was varied to establish the time required to achieve a high level of discriminative accuracy. Estimates of processing speed increased until about 11-13 years of age; beyond this, the trend was less obvious, and it is possible that inspection time asymptotes at around the onset of adolescence. Performance improvement after 1 year could not be explained as resulting from practice since improvement among controls over a period of 2 weeks was significantly less. Correlations between estimates of inspection time made up to 2 years apart found the measure to be reliable.     

Identification and adaptation of hue: Parallels in the operation of mechanisms that underlie categorical perception in vision and in audition

Summary Four experiments were conducted to examine processes in identification and selective adaptation of hues in color perception that exactly parallel processes in identification and adaptation of auditory detectors that provide information for phonemic perception. The first experiment demonstrated an effect of adaptation on identification of blue and green when a hue category center was used as the adaptor; this experiment also assessed recovery from adaptation. Adaptation to one hue was found to shift identification to favor the alternative hue, implicating a single detector underlying hue categorization. The second experiment demonstrated similar effects of adaptation between green and yellow. The third experiment compared the magnitudes of shift following adaptation with a category center, a near-boundary hue, and variously graded adaptation series. Adaptation was found to be related to the category representativeness of the adaptor(s). Results of the third experiment also provided support for the view that adaptation, rather than response bias, is responsible for shifts in the position of identification functions following extended stimulus exposure. The fourth experiment explored the neural loci of adaptation by an interocular transfer test. Hue adaptation was found to occur at both central and peripheral loci. In the four main experiments, reaction times to identify hues in unadapted and adapted states were also analyzed and compared. Subsidiary experiments assessed the effects of stimulus luminance on the magnitude of adaptation. General principles of categorical perception and its underlying bases, including the sweep, magnitude, and symmetry of adaptation, are discussed. The principal findings of these studies provide new data on hue perception which strikingly parallel findings in speech perception.     

Boundary disturbance in borderline and psychotic states

This study examines evidence for boundary disturbances in depressive, borderline, and schizophrenic hospitalized inpatients. Certain thought disorder signs on the Rorschach are reconceptualized as indices of boundary formation, which is defined as the capacity to create particular distinctions along wome bipolar coordinate of experience where previously no distinction was possible, and which defines each cluster of experience through a maintenance of differential functioning. The borderline group scored significantly high on the indices of laxness and moderately severe inner-outer boundary formation. The schizophrenic group scored significantly higher on indices of self-other and somewhat higher on severe inner-outer boundary disturbance. Schizophrenics may be organized at a level of self-other boundary formation which subsumes inner-outer boundary formation, while the borderline group is organized at a level of inner-outer boundary formation.     

Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Studying speech perception in adolescent school-age children by utilizing primary color perception

Since both speech and color have perceptual ramifications in language, the present study was developed to study speech perception through color perception. With the recent advances in perception generally and color perception specifically, this nontraditional approach to studying speech perception appeared reasonable. The 12 consonants utilized in this study generated 144 pairs of nonsense CV-syllables. The consonant ensemble was selected because it accommodated a maximum number of phonological features with a minimum number of phonemes. The 46 subjects, who were in junior high school with an age range of 11 through 14 years, responded to each of the stimulus pairs by assigning (associating) to it one of the six primary colors. Because of the perceptual orderliness associated with subjects' judgments, the results indicated that color can be used to study speech perception. Specific findings included the retrieval of sameness, fronting (or place), and voicing.This study is based on a master's thesis presented to the Graduate School, Tennessee State University in Nashville. The authors gratefully acknowledge the cooperation and assistance of the Speech and Hearing Institute at the University of Texas Health Science Center-Houston.