Antidepressant treatment of children: clinical relapse is unrelated to tricyclic plasma concentrations

Plasma concentrations of imipramine and amitriptyline and their desmethylated metabolites were measured in 20 children being treated for major depressive illness 2 wk. and 5 to 10 wk. after achieving drug dosages of 2.25 mg/kg body weight. At 2 wk. all children had exhibited clinical improvement, but by 10 wk. 4 of the 10 children treated with imipramine and 5 of the 10 children treated with amitriptyline had experienced clinical relapse of depressive symptoms. Tricyclic antidepressant plasma concentrations and ratios were comparable in the subgroups of children who maintained their clinical improvement and those who relapsed. There was no evidence of a systematic decline in plasma tricyclic antidepressant concentrations in those children who relapsed.     

Stimulus categorization by brain-damaged patients

Patients with localized insult to the right hemisphere, or to either the anterior or the posterior portion of the left hemisphere, as well as neurologically intact controls, evaluated stimuli on a seven-point rating scale for their degree of category membership. The stimuli were taken from one of two continua, one composed of fruit and vegetable items, and the other of items differing in hue and shape. Different subsets of stimuli provided different contexts for the judgments of category membership. The two left-hemisphere groups showed anomalies in categorizing the fruit and vegetable items but not the perceptual items, while the reverse was true for the right-hemisphere patients. Moreover, both left-hemisphere groups demonstrated context effects in their judgments of the representativeness of the fruit and vegetable items, but differed in the way in which they responded to changing contexts. Left posterior patients demonstrated weak category boundaries and even reclassified items. In contrast, patients with left anterior damage showed highly categorical responses and less differentiation of items within a category. All groups showed striking context effects in judgments of perceptual items in terms of changes in representativeness ratings and the location of a category boundary. Alternative interpretations of the results are offered.     

The ABCs of categorical perception

Studies of speech perception first revealed a surprising discontinuity in the way in which stimulus values on a physical continuum are perceived. Data which demonstrate the effect in nonspeech modes have challenged the contention that categorical perception is a hallmark of the speech mode, but the psychophysical models that have been proposed have not resolved the issues raised by empirical findings. This study provides data from judgments of four sensory continua, two visual and two tactual-kinesthetic, which show that the adaptation level for a set of stimuli serves as a category boundary whether stimuli on the continuum differ by linear or logarithmic increments. For all sensory continua studied, discrimination of stimuli belonging to different perceptual categories was more accurate than discrimination of stimuli belonging to the same perceptual category. Moreover, shifts in the adaptation level produced shifts in the location of the category boundary. The concept of Adaptation-level Based Categorization (ABC) provides a unified account of judgmental processes in categorical perception without recourse to post hoc constructs such as implicit anchors or external referents.     

INFLUENCE OF ASSESSMENT CENTER METHODS ON ASSESSORS'RATINGS

Recently a number of authors have argued persuasively that performance ratings are influenced to a large extent by the way the rater selects, organizes, stores, and recalls information. Although the influence of the rater's cognitive processes on the obtained ratings has been considered in the job-performance evaluation literature, this issue has not been considered in the assessment center literature. The purpose of the present study was to examine how assessment center methods affect the way assessors organize and process assessment center information and affect the ratings they make. Independent groups of assessors underwent one of two methods for evaluating candidates in an assessment center. Data indicated differences in the convergent and discriminant validities and differences in the factor structures of the ratings for the two methods. The pattern of results suggested that the two methods for evaluating assessment center candidates affected the way the assessors organized the assessment center information and affected the obtained ratings. Future research should consider assessment center methods and assessors as sources of variation in assessment center ratings.     

Postnatal development of respiratory and vocal responses during aversive classical conditioning in cats

Respiratory rate, respiration amplitude, and vocal responses were recorded in cats of different ages during classic conditioning. Vocal responses to the conditional stimulus (CS) appeared first in 8-week-old kittens, and became prominent at older ages. An increase in respiration rate occurred after the onset of the CS in cats of all ages. Similarly, the decrease of respiration amplitude was observed at all ages, but only in 8-week-old and older subjects did this response resemble an adult pattern. In 4-week-old kittens the response was characterized by an early and brief peak, suggesting an alpha conditional response (CR). Clear and significant discrimination between a warning and a safety signal was present in both respiratory and vocal responses after the age of 8 weeks.     

Intelligence and age as predictors of motor performance

The Yule-Oseretsky test of motor performance was administered to 10 ‘undifferentiated’ mentally-retarded adults, 10 normal children and 10 normal adults. In accordance with Denny's (1964) 3-group design, the children were matched on mental age with the retardates, the normal adults were matched on chronological age with the retardates, and the children and normal adults were matched on intelligence quotient. The results showed that mental age predicted performance on both fine and gross motor tasks, with the children and retarded adults both obtaining similar relatively-low scores.     

A LONGITUDINAL ANALYSIS OF BIOGRAPHICAL SUBGROUPS USING OWENS' DEVELOPMENTAL-INTEGRATIVE MODEL

The study examined the differential validity of 20 male and 14 female biographical subgroups in terms of 12 factor analyzed dimensions of postcollege experience. Owens' Developmental-Integrative Model hypothesizes that different subgroups of individuals with similar within-group early life experiences should exhibit significant differences (between-group) in a wide variety of life experiences. A sample of 1428 first-year college students were statistically grouped into 23 male and 15 female biodata subgroups after completing a standardized 118-item biodata form (Owens, 1968). Seven years later, a 97-item post-college experience inventory obtained scores for 484 of the original subjects on 12 factors of post-college behavior including job satisfaction, transition from college, personal and marital adjustment, and others. Significant univariate and multivariate differences were found between the biodata subgroups across the 7-year period. Implications for the validity of the D-I model are offered.